Detailed information NTG0180904

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: BWR56_RS00815
• Genome accession: NZ_CP019562
• Coordinates: 163659..166193 (+)
• Length: 844 a.a.
• NCBI ID: WP_076984271.1
• Uniprot ID: -
• Organism: Streptococcus oralis strain S.MIT/ORALIS-351
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 158659..171193

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BWR56_RS00790 (BWR56_0152)	nrdI	158727..159197 (+)	471	WP_070837149.1	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	-
BWR56_RS00795 (BWR56_0153)	-	159279..160541 (-)	1263	WP_076984269.1	NRAMP family divalent metal transporter	-
BWR56_RS00800 (BWR56_0154)	-	160740..160985 (-)	246	WP_076984270.1	MarR family transcriptional regulator	-
BWR56_RS00805 (BWR56_0155)	argS	161316..163007 (-)	1692	WP_049478944.1	arginine--tRNA ligase	-
BWR56_RS00810 (BWR56_0156)	argR	163162..163608 (+)	447	WP_001231483.1	arginine repressor	-
BWR56_RS00815 (BWR56_0157)	hexA	163659..166193 (+)	2535	WP_076984271.1	DNA mismatch repair protein MutS	Machinery gene
BWR56_RS00820 (BWR56_0158)	-	166235..166693 (-)	459	WP_070695986.1	DUF3021 domain-containing protein	-
BWR56_RS00825 (BWR56_0159)	-	166690..167130 (-)	441	WP_076984272.1	LytTR family DNA-binding domain-containing protein	-
BWR56_RS00835 (BWR56_0160)	hexB	167339..169288 (+)	1950	WP_065371519.1	DNA mismatch repair endonuclease MutL	Machinery gene
BWR56_RS00840 (BWR56_0161)	-	169429..169926 (-)	498	WP_065371520.1	helix-turn-helix domain-containing protein	-

Sequence

Protein

• Length: 844 a.a.
• Molecular weight: 94666.07 Da
• Isoelectric Point: 4.8297

>NTDB_id=180904 BWR56_RS00815 WP_076984271.1 163659..166193(+) (hexA) [Streptococcus oralis strain S.MIT/ORALIS-351]
MATEKLSPGMQQYVDIKKQYPDAFLLFRMGDFYELFYEDAINAAQILEISLTSRNKNAENPIPMAGVPYHSAQQYIDVLI
EQGYKVAIAEQMEDPKQAVGVVKREVVQVITPGTVVDSSKPDSQNNFLVSLDCDGNQFGLAYMDLVTGDFYVTGLLDFTL
VCGEVRNLKAREVVLGYNLSEEEEQILSRQMNLVLSYEKEGFEDIHLLDSRLAAVEQAAASKLLQYVHRTQMRELNHLKP
VIRYEIKDFLQMDFATKASLDLVENARSGKKQGSLFWLLDETKTAMGMRLLRSWIHRPLIDKERIVQRQEVVQVFLDHFF
ERSDLTDSLKGVYDIERLASRVSFGKTNPKDLLQLATTLSSVPRIRAILEGMEQPALAYLIEQLDAIPELESLISAAIAP
EAPHVITEGGIIRTGFDETLDKYRRVLREGTSWIAEIEAKERENSGISTLKIDYNKKDGYYFHVTNSQLGNVPAHFFRKA
TLKNSERFGTEELARIEGDMLEAREKSANLEYEIFMRIREEVSKYIQRLQALAQGIATVDVLQSLAVVAETQHLIRPEFG
DDSQIDIQKGRHAVVEKVMGAQTYIPNSIQMAEDTSIQLITGPNMSGKSTYMRQLAMTAVMAQLGSYVPAESAHLPIFDA
IFTRIGAADDLVSGQSTFMVEMMEANNAISHATKDSLILFDELGRGTATYDGMALAQSIIEYIHEHIGAKTLFATHYHEL
TSLESSLEHLVNVHVATLEQNGQVTFLHKIEPGPADKSYGIHVAKIAGLPAELLARADKILTQLENQGTESPAPMRETSD
VTEQMSLFDAPAEHPILAELVKLDVYNMTPMQAMNVLVELKQKL

Nucleotide

• Length: 2535 bp

>NTDB_id=180904 BWR56_RS00815 WP_076984271.1 163659..166193(+) (hexA) [Streptococcus oralis strain S.MIT/ORALIS-351]
ATGGCAACAGAAAAGCTATCACCCGGCATGCAACAGTATGTGGATATTAAGAAACAATACCCAGATGCTTTTTTGCTTTT
TCGAATGGGTGATTTTTACGAGTTGTTCTATGAAGATGCAATTAATGCAGCACAGATTTTAGAAATTTCCTTAACGAGTC
GGAATAAAAATGCAGAAAATCCGATACCTATGGCGGGCGTCCCCTATCATTCTGCCCAACAGTATATCGATGTTCTGATT
GAGCAGGGCTATAAGGTAGCCATAGCCGAGCAGATGGAAGATCCCAAACAAGCAGTTGGTGTTGTCAAGCGAGAGGTGGT
CCAGGTCATCACACCTGGAACGGTCGTTGATAGCAGTAAGCCGGATAGTCAGAATAATTTCTTGGTTTCCTTAGATTGTG
ATGGCAATCAATTTGGTCTGGCTTATATGGATTTGGTGACGGGTGACTTTTATGTGACGGGGCTATTGGATTTCACGTTG
GTTTGTGGGGAAGTCCGTAACCTCAAGGCGCGAGAAGTGGTGCTGGGTTATAACTTGTCTGAGGAAGAAGAACAAATCCT
CAGCCGTCAGATGAATCTGGTGCTTTCTTATGAGAAGGAAGGCTTTGAGGATATTCATTTACTAGATTCACGTTTGGCAG
CTGTGGAGCAAGCGGCAGCTAGTAAGCTGCTCCAGTATGTTCACCGGACCCAGATGCGGGAATTGAACCATCTCAAACCA
GTTATCCGCTATGAAATCAAAGATTTCTTACAGATGGACTTTGCGACCAAGGCTAGTCTGGATTTGGTTGAGAATGCCCG
TTCAGGTAAGAAGCAAGGGAGTCTTTTCTGGCTTTTGGATGAAACCAAAACAGCTATGGGCATGCGGCTCTTGCGTTCTT
GGATTCATCGTCCTTTGATTGATAAGGAGCGAATCGTCCAACGTCAAGAGGTGGTGCAGGTCTTTCTTGACCATTTCTTT
GAGCGTAGTGATTTAACGGATAGCCTCAAGGGTGTTTATGACATCGAACGCTTGGCTAGTCGGGTTTCTTTTGGCAAGAC
CAATCCCAAGGATCTCTTACAGTTAGCGACCACCTTGTCTAGTGTGCCACGGATTCGTGCGATTTTAGAGGGAATGGAGC
AACCTGCTCTAGCCTATCTCATCGAACAGTTGGATGCCATTCCTGAGTTGGAGAGCTTGATTAGTGCAGCGATTGCTCCT
GAAGCTCCTCATGTGATTACGGAAGGTGGTATTATCCGGACTGGATTTGATGAAACCTTGGATAAATACCGTCGAGTGCT
CAGAGAAGGGACCAGTTGGATTGCTGAGATTGAGGCTAAGGAGCGAGAAAACTCTGGTATCAGCACGCTTAAGATTGACT
ACAATAAAAAGGATGGCTACTATTTCCATGTGACTAATTCGCAACTGGGAAATGTGCCAGCCCACTTTTTCCGCAAGGCG
ACGTTGAAAAATTCGGAACGCTTTGGTACCGAGGAATTAGCCCGTATCGAGGGAGATATGCTGGAGGCGCGCGAGAAGTC
AGCCAACCTAGAATATGAAATCTTTATGCGTATCCGTGAGGAAGTCAGCAAGTACATCCAGCGTTTGCAGGCTCTAGCCC
AAGGAATTGCAACGGTTGATGTCTTGCAAAGTCTAGCAGTTGTGGCTGAAACCCAGCATTTGATCCGACCTGAGTTTGGA
GACGATTCACAAATTGATATCCAGAAAGGGCGCCATGCTGTCGTCGAAAAGGTCATGGGAGCTCAGACCTATATTCCAAA
TAGTATCCAGATGGCAGAAGATACGAGTATTCAGCTAATTACAGGGCCCAACATGAGTGGGAAGTCAACCTACATGCGCC
AGTTAGCCATGACTGCGGTTATGGCCCAGCTGGGTTCTTATGTGCCGGCAGAAAGCGCCCATTTGCCGATCTTCGATGCC
ATCTTTACCCGTATCGGAGCAGCAGATGACTTGGTTTCAGGTCAATCAACCTTCATGGTGGAGATGATGGAGGCCAACAA
TGCCATTTCGCATGCGACCAAGGATTCCTTGATTCTCTTTGATGAATTGGGACGCGGAACTGCAACTTATGACGGGATGG
CTCTTGCTCAATCCATCATCGAATACATCCATGAACATATCGGAGCCAAAACCCTCTTTGCTACCCACTACCATGAGCTG
ACCAGTCTGGAGTCTAGCTTGGAACACTTGGTCAATGTCCACGTGGCAACCTTGGAGCAGAATGGGCAGGTCACCTTCCT
TCACAAGATCGAGCCAGGACCAGCTGACAAATCCTATGGTATTCACGTTGCTAAGATTGCTGGCTTGCCAGCAGAACTTT
TAGCAAGGGCGGATAAGATATTGACTCAACTGGAGAATCAAGGGACGGAAAGTCCTGCTCCGATGAGAGAAACAAGTGAT
GTTACTGAACAGATGTCACTTTTTGACGCGCCTGCAGAGCATCCTATCCTAGCAGAATTAGTTAAACTGGATGTTTACAA
TATGACACCTATGCAGGCTATGAATGTCTTGGTCGAGCTCAAACAAAAGTTATAA

Domains

Predicted by InterProScan.

• MutS family domain IV (MutS_IV) (415-505)

• MutS domain V (MutS_V) (599-785)

• MutS domain III (MutS_III) (256-546)

• MutS domain I (MutS_I) (8-118)

• MutS domain II (MutS_II) (126-239)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	95.735	100	0.957
mutS	Pseudomonas stutzeri strain ATCC 17587	36.799	100	0.373