Detailed information
Bioinformatically predicted
Overview
| Name | ccrB | Type | Machinery gene |
| Locus tag | A2I68_RS12635 | Genome accession | NZ_CP015553 |
| Coordinates | 2514782..2516407 (+) | Length | 541 a.a. |
| NCBI ID | WP_046099800.1 | Uniprot ID | A0AAJ0JPE0 |
| Organism | Staphylococcus carnosus strain TMW 2.1596 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 2513411..2570481 | 2514782..2516407 | within | 0 |
Gene organization within MGE regions
Location: 2513411..2570481
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A2I68_RS12630 (A2I68_12345) | ccrA | 2513411..2514760 (+) | 1350 | WP_046099801.1 | recombinase family protein | Machinery gene |
| A2I68_RS12635 (A2I68_12350) | ccrB | 2514782..2516407 (+) | 1626 | WP_046099800.1 | recombinase family protein | Machinery gene |
| A2I68_RS12640 (A2I68_12355) | - | 2516882..2517220 (+) | 339 | Protein_2462 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| A2I68_RS12645 (A2I68_12360) | - | 2517316..2517627 (+) | 312 | WP_046099799.1 | DUF960 family protein | - |
| A2I68_RS12650 (A2I68_12365) | - | 2517641..2518141 (+) | 501 | WP_046099798.1 | DUF1643 domain-containing protein | - |
| A2I68_RS12655 (A2I68_12370) | - | 2518156..2518377 (+) | 222 | WP_046099797.1 | hypothetical protein | - |
| A2I68_RS12660 (A2I68_12375) | - | 2518442..2518690 (-) | 249 | WP_046099796.1 | hypothetical protein | - |
| A2I68_RS12665 (A2I68_12380) | - | 2518741..2519967 (-) | 1227 | WP_046099795.1 | restriction endonuclease subunit S | - |
| A2I68_RS12670 (A2I68_12385) | - | 2519960..2521516 (-) | 1557 | WP_046099794.1 | type I restriction-modification system subunit M | - |
| A2I68_RS12675 (A2I68_12390) | - | 2521517..2522098 (-) | 582 | WP_046099793.1 | restriction endonuclease subunit S | - |
| A2I68_RS12680 (A2I68_12395) | - | 2522188..2524980 (-) | 2793 | WP_046099792.1 | type I restriction endonuclease subunit R | - |
| A2I68_RS12685 (A2I68_12400) | - | 2525454..2526770 (-) | 1317 | WP_046099791.1 | glycosyltransferase family 2 protein | - |
| A2I68_RS12690 (A2I68_12405) | - | 2526990..2528627 (-) | 1638 | WP_052719452.1 | DUF6270 domain-containing protein | - |
| A2I68_RS12695 (A2I68_12410) | - | 2528637..2530628 (-) | 1992 | WP_253719802.1 | CDP-glycerol glycerophosphotransferase family protein | - |
| A2I68_RS12700 (A2I68_12415) | - | 2530664..2531785 (-) | 1122 | WP_046099789.1 | glycosyltransferase family 2 protein | - |
| A2I68_RS12705 (A2I68_12420) | galU | 2532044..2532911 (-) | 868 | Protein_2475 | UTP--glucose-1-phosphate uridylyltransferase GalU | - |
| A2I68_RS12710 (A2I68_12425) | - | 2533204..2533749 (-) | 546 | WP_046099788.1 | hypothetical protein | - |
| A2I68_RS12715 (A2I68_12430) | - | 2533769..2534332 (-) | 564 | WP_046099787.1 | hypothetical protein | - |
| A2I68_RS12720 | - | 2534471..2534629 (-) | 159 | WP_235318576.1 | hypothetical protein | - |
| A2I68_RS12725 (A2I68_12435) | - | 2534635..2534961 (-) | 327 | WP_235318575.1 | hypothetical protein | - |
| A2I68_RS12730 (A2I68_12440) | - | 2534977..2535267 (-) | 291 | WP_046099786.1 | hypothetical protein | - |
| A2I68_RS12735 (A2I68_12445) | - | 2535324..2536196 (-) | 873 | WP_046099785.1 | HTH domain-containing protein | - |
| A2I68_RS12740 (A2I68_12450) | - | 2536366..2536812 (-) | 447 | WP_046099784.1 | JAB domain-containing protein | - |
| A2I68_RS12745 (A2I68_12455) | - | 2536840..2537346 (-) | 507 | WP_046099783.1 | DUF1643 domain-containing protein | - |
| A2I68_RS12750 (A2I68_12460) | - | 2537361..2537672 (-) | 312 | WP_046099782.1 | DUF960 family protein | - |
| A2I68_RS12755 (A2I68_12465) | - | 2537768..2538106 (-) | 339 | WP_037576898.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| A2I68_RS12760 (A2I68_12470) | - | 2538212..2539888 (-) | 1677 | WP_046099781.1 | recombinase family protein | - |
| A2I68_RS12765 (A2I68_12475) | - | 2540113..2541756 (-) | 1644 | WP_046099780.1 | DUF5906 domain-containing protein | - |
| A2I68_RS12770 (A2I68_12480) | - | 2541756..2542124 (-) | 369 | WP_046099779.1 | hypothetical protein | - |
| A2I68_RS12775 (A2I68_12485) | - | 2542117..2543226 (-) | 1110 | WP_046099778.1 | DNA polymerase | - |
| A2I68_RS12780 (A2I68_12490) | - | 2543424..2545433 (-) | 2010 | WP_046099777.1 | hypothetical protein | - |
| A2I68_RS12785 (A2I68_12495) | - | 2545463..2546314 (-) | 852 | WP_046099776.1 | hypothetical protein | - |
| A2I68_RS12790 | - | 2546631..2546819 (-) | 189 | WP_253719803.1 | hypothetical protein | - |
| A2I68_RS12795 (A2I68_12505) | - | 2547112..2548404 (-) | 1293 | WP_046099775.1 | NtaA/DmoA family FMN-dependent monooxygenase | - |
| A2I68_RS12800 (A2I68_12510) | - | 2548607..2549380 (-) | 774 | WP_046099774.1 | acetoin reductase | - |
| A2I68_RS12805 (A2I68_12515) | ccrA | 2549766..2551115 (+) | 1350 | WP_046099773.1 | recombinase family protein | Machinery gene |
| A2I68_RS12810 (A2I68_12520) | ccrB | 2551136..2552764 (+) | 1629 | WP_046099772.1 | recombinase family protein | Machinery gene |
| A2I68_RS12815 (A2I68_12525) | - | 2553166..2553294 (+) | 129 | Protein_2497 | NAD-dependent protein deacylase | - |
| A2I68_RS12820 (A2I68_12530) | deoB | 2553340..2554518 (-) | 1179 | WP_046099770.1 | phosphopentomutase | - |
| A2I68_RS12825 (A2I68_12535) | deoC | 2554547..2555209 (-) | 663 | WP_046099769.1 | deoxyribose-phosphate aldolase | - |
| A2I68_RS12830 (A2I68_12540) | - | 2555223..2556578 (-) | 1356 | WP_046099768.1 | tetracycline resistance MFS efflux pump | - |
| A2I68_RS12835 (A2I68_12545) | deoD | 2556591..2557298 (-) | 708 | WP_046099767.1 | purine-nucleoside phosphorylase | - |
| A2I68_RS12840 (A2I68_12550) | - | 2557641..2558378 (-) | 738 | WP_046099892.1 | GntR family transcriptional regulator | - |
| A2I68_RS12850 (A2I68_12555) | - | 2559271..2560632 (-) | 1362 | WP_046099766.1 | gluconate:H+ symporter | - |
| A2I68_RS12855 (A2I68_12560) | - | 2560651..2562096 (-) | 1446 | WP_082080567.1 | four-carbon acid sugar kinase family protein | - |
| A2I68_RS12860 (A2I68_12565) | - | 2562508..2563809 (-) | 1302 | WP_046099765.1 | ATP-binding protein | - |
| A2I68_RS12865 (A2I68_12570) | - | 2563848..2564897 (-) | 1050 | WP_046099764.1 | hypothetical protein | - |
| A2I68_RS12870 (A2I68_12575) | - | 2565034..2565327 (+) | 294 | WP_046099763.1 | DUF1413 domain-containing protein | - |
| A2I68_RS12875 (A2I68_12580) | - | 2565327..2567114 (+) | 1788 | WP_046099762.1 | DUF927 domain-containing protein | - |
| A2I68_RS12880 (A2I68_12585) | - | 2567183..2567458 (+) | 276 | WP_046099761.1 | hypothetical protein | - |
| A2I68_RS12885 (A2I68_12590) | ccrA | 2567650..2568999 (+) | 1350 | WP_046099890.1 | recombinase family protein | Machinery gene |
Sequence
Protein
Download Length: 541 a.a. Molecular weight: 62149.16 Da Isoelectric Point: 9.8140
>NTDB_id=180646 A2I68_RS12635 WP_046099800.1 2514782..2516407(+) (ccrB) [Staphylococcus carnosus strain TMW 2.1596]
MSEMKKKRIGGYIRVSTEKQVMGYSIEGQITQIEQYCQFNGYELVDIYADRGISGKSMNRPELQRMLNDAKNGKLDCVMV
YKTNRLARNTSDLLTIVEELHRQNVEFFSLSERMEVKNSTGKLMLQILASFSEFERNKILENIYNGQHQRALEGYYQGNL
PLGYNNIPDNKKELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGNPFSISAVTYILSNPFYIGKIQFAKY
KDWNDKRRKGLNDKPVIAEGKHTPIISQSLWDKVQARKKQVSEKPQVHGKGTNILTGLISCPQCSASMSASTTVNTLKDG
TKKRIRYYSCSNFRNKGSKVCSANSVRADVIEKYVMDQILEIVKSDKVLKQVVERVNQENHVDVAALNHDIAYKQQQFDE
INTKLKNLIQTIEDNPDLTSALKPTIHQYETQLNDITNQMNQLKHQQNQEKPSYDTKQIAALLQQIFQNIESMDKAQLKA
LYLTVIDRIDIRKNGSHKKQFFVTLKLNNEIIKQLFNNTSLDEVLLSTSSLFLPQTLFLQI
MSEMKKKRIGGYIRVSTEKQVMGYSIEGQITQIEQYCQFNGYELVDIYADRGISGKSMNRPELQRMLNDAKNGKLDCVMV
YKTNRLARNTSDLLTIVEELHRQNVEFFSLSERMEVKNSTGKLMLQILASFSEFERNKILENIYNGQHQRALEGYYQGNL
PLGYNNIPDNKKELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGNPFSISAVTYILSNPFYIGKIQFAKY
KDWNDKRRKGLNDKPVIAEGKHTPIISQSLWDKVQARKKQVSEKPQVHGKGTNILTGLISCPQCSASMSASTTVNTLKDG
TKKRIRYYSCSNFRNKGSKVCSANSVRADVIEKYVMDQILEIVKSDKVLKQVVERVNQENHVDVAALNHDIAYKQQQFDE
INTKLKNLIQTIEDNPDLTSALKPTIHQYETQLNDITNQMNQLKHQQNQEKPSYDTKQIAALLQQIFQNIESMDKAQLKA
LYLTVIDRIDIRKNGSHKKQFFVTLKLNNEIIKQLFNNTSLDEVLLSTSSLFLPQTLFLQI
Nucleotide
Download Length: 1626 bp
>NTDB_id=180646 A2I68_RS12635 WP_046099800.1 2514782..2516407(+) (ccrB) [Staphylococcus carnosus strain TMW 2.1596]
ATGAGTGAAATGAAGAAGAAGAGAATCGGAGGGTACATCCGCGTATCCACTGAAAAACAGGTAATGGGCTATAGCATCGA
GGGGCAAATTACACAAATAGAGCAATATTGCCAATTTAACGGCTATGAACTCGTTGATATATATGCAGATCGGGGTATAT
CAGGAAAATCTATGAACCGTCCTGAATTACAGCGCATGTTAAATGATGCTAAAAATGGAAAATTAGACTGTGTTATGGTT
TATAAAACAAATCGTTTGGCACGTAATACTTCCGATTTACTTACAATCGTCGAAGAACTTCATCGCCAAAATGTTGAATT
TTTTAGCTTGTCTGAACGCATGGAAGTCAAAAATTCAACAGGCAAGTTAATGCTCCAAATACTTGCAAGTTTTTCCGAAT
TTGAAAGAAATAAAATTTTAGAGAATATTTACAACGGTCAACATCAAAGAGCTTTAGAGGGCTATTATCAAGGCAATCTT
CCATTAGGATACAATAACATACCTGATAATAAAAAAGAATTAATGATTAATCAACATGAAGCTAACATCGTTAAATATAT
CTTTGAATCTTATGCCAAAGGTCATGGCTATCGTAAAATAGCCAATGCACTCAATCATAAAGGTTATGTCACTAAGAAAG
GCAATCCATTTAGTATTTCAGCTGTTACTTATATTCTCTCAAACCCATTCTATATTGGTAAAATTCAATTCGCGAAATAC
AAAGATTGGAATGATAAACGTCGTAAAGGCTTGAATGATAAGCCAGTAATCGCCGAAGGCAAACACACCCCTATTATTAG
CCAATCATTATGGGATAAAGTCCAAGCACGTAAAAAACAAGTAAGTGAAAAACCACAAGTCCATGGTAAAGGAACCAATA
TTTTAACTGGATTAATTTCGTGTCCACAATGTTCTGCTTCAATGTCTGCGAGCACAACAGTTAATACACTTAAAGATGGA
ACTAAGAAACGCATTCGCTATTATTCTTGTAGTAACTTTCGCAACAAAGGATCAAAGGTATGTTCGGCCAATAGTGTTAG
AGCCGATGTCATTGAAAAATATGTTATGGACCAAATACTTGAAATTGTCAAAAGTGATAAAGTTCTCAAACAAGTTGTCG
AACGCGTCAATCAAGAGAATCATGTAGATGTAGCAGCACTCAACCATGATATTGCTTATAAACAACAACAATTTGATGAA
ATTAACACTAAACTTAAAAATCTAATTCAAACCATCGAAGACAATCCAGACTTAACATCTGCACTCAAACCAACCATTCA
TCAATATGAAACACAACTGAATGATATCACAAACCAAATGAATCAACTCAAGCACCAACAAAATCAAGAGAAACCATCTT
ATGATACGAAACAGATCGCTGCCCTATTACAACAAATATTTCAAAACATAGAATCAATGGATAAAGCACAACTCAAAGCA
TTATACCTTACGGTCATTGACCGTATTGATATTCGTAAAAATGGAAGTCATAAAAAACAATTCTTTGTCACACTCAAGCT
CAATAATGAGATTATTAAACAACTTTTCAATAATACCTCTCTCGACGAAGTGCTCCTCAGCACTTCGTCTTTATTTTTGC
CTCAAACGCTCTTTCTTCAAATCTAA
ATGAGTGAAATGAAGAAGAAGAGAATCGGAGGGTACATCCGCGTATCCACTGAAAAACAGGTAATGGGCTATAGCATCGA
GGGGCAAATTACACAAATAGAGCAATATTGCCAATTTAACGGCTATGAACTCGTTGATATATATGCAGATCGGGGTATAT
CAGGAAAATCTATGAACCGTCCTGAATTACAGCGCATGTTAAATGATGCTAAAAATGGAAAATTAGACTGTGTTATGGTT
TATAAAACAAATCGTTTGGCACGTAATACTTCCGATTTACTTACAATCGTCGAAGAACTTCATCGCCAAAATGTTGAATT
TTTTAGCTTGTCTGAACGCATGGAAGTCAAAAATTCAACAGGCAAGTTAATGCTCCAAATACTTGCAAGTTTTTCCGAAT
TTGAAAGAAATAAAATTTTAGAGAATATTTACAACGGTCAACATCAAAGAGCTTTAGAGGGCTATTATCAAGGCAATCTT
CCATTAGGATACAATAACATACCTGATAATAAAAAAGAATTAATGATTAATCAACATGAAGCTAACATCGTTAAATATAT
CTTTGAATCTTATGCCAAAGGTCATGGCTATCGTAAAATAGCCAATGCACTCAATCATAAAGGTTATGTCACTAAGAAAG
GCAATCCATTTAGTATTTCAGCTGTTACTTATATTCTCTCAAACCCATTCTATATTGGTAAAATTCAATTCGCGAAATAC
AAAGATTGGAATGATAAACGTCGTAAAGGCTTGAATGATAAGCCAGTAATCGCCGAAGGCAAACACACCCCTATTATTAG
CCAATCATTATGGGATAAAGTCCAAGCACGTAAAAAACAAGTAAGTGAAAAACCACAAGTCCATGGTAAAGGAACCAATA
TTTTAACTGGATTAATTTCGTGTCCACAATGTTCTGCTTCAATGTCTGCGAGCACAACAGTTAATACACTTAAAGATGGA
ACTAAGAAACGCATTCGCTATTATTCTTGTAGTAACTTTCGCAACAAAGGATCAAAGGTATGTTCGGCCAATAGTGTTAG
AGCCGATGTCATTGAAAAATATGTTATGGACCAAATACTTGAAATTGTCAAAAGTGATAAAGTTCTCAAACAAGTTGTCG
AACGCGTCAATCAAGAGAATCATGTAGATGTAGCAGCACTCAACCATGATATTGCTTATAAACAACAACAATTTGATGAA
ATTAACACTAAACTTAAAAATCTAATTCAAACCATCGAAGACAATCCAGACTTAACATCTGCACTCAAACCAACCATTCA
TCAATATGAAACACAACTGAATGATATCACAAACCAAATGAATCAACTCAAGCACCAACAAAATCAAGAGAAACCATCTT
ATGATACGAAACAGATCGCTGCCCTATTACAACAAATATTTCAAAACATAGAATCAATGGATAAAGCACAACTCAAAGCA
TTATACCTTACGGTCATTGACCGTATTGATATTCGTAAAAATGGAAGTCATAAAAAACAATTCTTTGTCACACTCAAGCT
CAATAATGAGATTATTAAACAACTTTTCAATAATACCTCTCTCGACGAAGTGCTCCTCAGCACTTCGTCTTTATTTTTGC
CTCAAACGCTCTTTCTTCAAATCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrB | Staphylococcus aureus N315 |
78.598 |
100 |
0.787 |