Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | A6V38_RS00520 | Genome accession | NZ_CP015447 |
| Coordinates | 96571..97917 (-) | Length | 448 a.a. |
| NCBI ID | WP_000816499.1 | Uniprot ID | Q9R3W9 |
| Organism | Staphylococcus aureus strain M92 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 40889..97917 | 96571..97917 | within | 0 |
Gene organization within MGE regions
Location: 40889..97917
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| A6V38_RS00175 (A6V38_00175) | ccrC | 40889..42574 (+) | 1686 | WP_000676600.1 | cassette chromosome recombinase CcrC | - |
| A6V38_RS00180 (A6V38_00180) | tnpA | 42622..43107 (+) | 486 | WP_000093392.1 | IS200/IS605 family transposase | - |
| A6V38_RS00185 (A6V38_00185) | - | 43399..43737 (+) | 339 | WP_000175892.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| A6V38_RS00195 (A6V38_00190) | - | 43831..44142 (+) | 312 | WP_001166716.1 | DUF960 family protein | - |
| A6V38_RS00200 (A6V38_00195) | - | 44158..44664 (+) | 507 | WP_000848380.1 | DUF1643 domain-containing protein | - |
| A6V38_RS00205 (A6V38_00200) | - | 44685..45002 (+) | 318 | WP_000659046.1 | JAB domain-containing protein | - |
| A6V38_RS00210 (A6V38_00205) | - | 45121..46206 (+) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| A6V38_RS00215 (A6V38_00210) | - | 46203..48095 (+) | 1893 | Protein_37 | site-specific integrase | - |
| A6V38_RS00220 (A6V38_00215) | - | 48102..48479 (+) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| A6V38_RS00225 (A6V38_16150) | ant(9) | 48630..49412 (+) | 783 | Protein_39 | aminoglycoside nucleotidyltransferase ANT(9) | - |
| A6V38_RS00230 (A6V38_00230) | erm(A) | 49538..50269 (-) | 732 | WP_031863781.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| A6V38_RS16345 (A6V38_16155) | - | 50352..50411 (-) | 60 | WP_010959190.1 | erythromycin resistance leader peptide | - |
| A6V38_RS00245 (A6V38_00240) | - | 50803..51465 (+) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| A6V38_RS00250 (A6V38_00245) | - | 51697..51843 (+) | 147 | Protein_43 | JAB domain-containing protein | - |
| A6V38_RS00255 (A6V38_00250) | - | 52013..52885 (+) | 873 | WP_000373151.1 | HTH domain-containing protein | - |
| A6V38_RS00260 (A6V38_00255) | - | 52942..53232 (+) | 291 | WP_000065262.1 | hypothetical protein | - |
| A6V38_RS00265 (A6V38_00260) | - | 53248..53736 (+) | 489 | WP_000397419.1 | hypothetical protein | - |
| A6V38_RS00270 (A6V38_00265) | - | 53871..54398 (+) | 528 | WP_000717928.1 | hypothetical protein | - |
| A6V38_RS00275 (A6V38_00270) | - | 54460..54876 (+) | 417 | WP_000941331.1 | hypothetical protein | - |
| A6V38_RS16115 | - | 55165..55329 (+) | 165 | WP_001803222.1 | hypothetical protein | - |
| A6V38_RS00280 (A6V38_00275) | - | 55343..55564 (+) | 222 | WP_001070883.1 | hypothetical protein | - |
| A6V38_RS00285 (A6V38_00280) | - | 55714..56280 (+) | 567 | WP_000759939.1 | PepSY domain-containing protein | - |
| A6V38_RS00290 (A6V38_00285) | - | 56360..58573 (-) | 2214 | Protein_52 | type I restriction endonuclease subunit R | - |
| A6V38_RS00295 (A6V38_00290) | - | 58635..59309 (-) | 675 | WP_001105999.1 | IS6-like element IS257 family transposase | - |
| A6V38_RS00300 (A6V38_00295) | - | 59592..60938 (+) | 1347 | WP_162564149.1 | NAD(P)/FAD-dependent oxidoreductase | - |
| A6V38_RS00305 (A6V38_00300) | merR | 61238..61645 (+) | 408 | WP_000425271.1 | Hg(II)-responsive transcriptional regulator MerR | - |
| A6V38_RS00310 (A6V38_00305) | - | 61662..62015 (+) | 354 | WP_110175111.1 | TlpA disulfide reductase family protein | - |
| A6V38_RS00315 (A6V38_00315) | - | 62012..62692 (+) | 681 | WP_000010352.1 | cytochrome c biogenesis CcdA family protein | - |
| A6V38_RS00320 (A6V38_00320) | merT | 62780..63166 (+) | 387 | WP_001794630.1 | mercuric transport protein MerT | - |
| A6V38_RS00325 (A6V38_00325) | merA | 63224..64867 (+) | 1644 | WP_000193219.1 | mercury(II) reductase | - |
| A6V38_RS00330 (A6V38_00330) | merB | 64949..65599 (+) | 651 | WP_000790333.1 | organomercurial lyase MerB | - |
| A6V38_RS00340 (A6V38_00340) | - | 65794..66309 (-) | 516 | WP_000377078.1 | hypothetical protein | - |
| A6V38_RS00345 (A6V38_00345) | - | 66428..67102 (-) | 675 | WP_001105988.1 | IS6-like element IS257 family transposase | - |
| A6V38_RS16350 (A6V38_00350) | - | 67535..67867 (-) | 333 | WP_001803416.1 | DUF3021 domain-containing protein | - |
| A6V38_RS00355 (A6V38_00355) | - | 67896..68138 (-) | 243 | WP_001803415.1 | LytTR family DNA-binding domain-containing protein | - |
| A6V38_RS00360 (A6V38_00360) | - | 68270..68944 (-) | 675 | WP_001106055.1 | IS6-like element IS257 family transposase | - |
| A6V38_RS00365 (A6V38_00365) | tet(K) | 69141..70520 (+) | 1380 | WP_000492283.1 | tetracycline efflux MFS transporter Tet(K) | - |
| A6V38_RS00370 (A6V38_00370) | mobV | 70706..71947 (+) | 1242 | WP_000122374.1 | MobV family relaxase | - |
| A6V38_RS00375 (A6V38_00375) | - | 72474..73428 (+) | 955 | Protein_68 | replication initiation factor domain-containing protein | - |
| A6V38_RS00380 (A6V38_00380) | - | 73517..74191 (-) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| A6V38_RS00385 (A6V38_00385) | - | 74227..74616 (+) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| A6V38_RS00395 (A6V38_00395) | - | 75493..76236 (+) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| A6V38_RS00400 (A6V38_00400) | - | 76333..76761 (+) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| A6V38_RS00405 (A6V38_00405) | mecA | 76807..78816 (-) | 2010 | WP_078056515.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| A6V38_RS00410 (A6V38_00410) | mecR1 | 78913..80670 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| A6V38_RS00415 (A6V38_00415) | mecI | 80670..81041 (+) | 372 | Protein_75 | mecA-type methicillin resistance repressor MecI | - |
| A6V38_RS00420 (A6V38_16165) | psm-mec | 81126..81194 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| A6V38_RS00425 (A6V38_00430) | - | 81514..82662 (+) | 1149 | WP_000427807.1 | ROK family transcriptional regulator | - |
| A6V38_RS00435 (A6V38_00435) | cstB | 82776..84110 (-) | 1335 | Protein_78 | persulfide dioxygenase-sulfurtransferase CstB | - |
| A6V38_RS00440 (A6V38_00440) | - | 84142..85206 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| A6V38_RS00445 (A6V38_00445) | cstR | 85342..85602 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| A6V38_RS00450 (A6V38_00450) | - | 85602..86240 (+) | 639 | Protein_81 | sulfite exporter TauE/SafE family protein | - |
| A6V38_RS00460 (A6V38_00460) | - | 86514..87131 (-) | 618 | WP_000562107.1 | CadD family cadmium resistance transporter | - |
| A6V38_RS00465 (A6V38_00465) | - | 87212..89626 (-) | 2415 | WP_000378485.1 | cadmium-translocating P-type ATPase CadA | - |
| A6V38_RS00470 (A6V38_00470) | - | 89619..89984 (-) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| A6V38_RS00475 (A6V38_00475) | - | 90170..90547 (-) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| A6V38_RS00480 (A6V38_00480) | - | 90554..92446 (-) | 1893 | WP_072387024.1 | site-specific integrase | - |
| A6V38_RS00485 (A6V38_00485) | - | 92641..92964 (-) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| A6V38_RS00490 (A6V38_00490) | - | 92957..93163 (-) | 207 | WP_001077283.1 | hypothetical protein | - |
| A6V38_RS00495 (A6V38_00495) | - | 93165..93686 (-) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| A6V38_RS00500 (A6V38_00500) | - | 93705..94016 (-) | 312 | WP_000833212.1 | DUF960 family protein | - |
| A6V38_RS00510 (A6V38_00505) | - | 94101..94451 (-) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| A6V38_RS00515 (A6V38_00510) | ccrB | 94922..96550 (-) | 1629 | WP_001186596.1 | cassette chromosome recombinase CcrB | Machinery gene |
| A6V38_RS00520 (A6V38_00515) | ccrA | 96571..97917 (-) | 1347 | WP_000816499.1 | cassette chromosome recombinase CcrA | Machinery gene |
Sequence
Protein
Download Length: 448 a.a. Molecular weight: 52138.19 Da Isoelectric Point: 10.1760
>NTDB_id=179907 A6V38_RS00520 WP_000816499.1 96571..97917(-) (ccrA) [Staphylococcus aureus strain M92]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
Nucleotide
Download Length: 1347 bp
>NTDB_id=179907 A6V38_RS00520 WP_000816499.1 96571..97917(-) (ccrA) [Staphylococcus aureus strain M92]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
78.174 |
100 |
0.783 |
| ccrA | Staphylococcus aureus N315 |
72.383 |
100 |
0.725 |