Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrB   Type   Machinery gene
Locus tag   A6V38_RS00515 Genome accession   NZ_CP015447
Coordinates   94922..96550 (-) Length   542 a.a.
NCBI ID   WP_001186596.1    Uniprot ID   -
Organism   Staphylococcus aureus strain M92     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 40889..97917 94922..96550 within 0


Gene organization within MGE regions


Location: 40889..97917
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A6V38_RS00175 (A6V38_00175) ccrC 40889..42574 (+) 1686 WP_000676600.1 cassette chromosome recombinase CcrC -
  A6V38_RS00180 (A6V38_00180) tnpA 42622..43107 (+) 486 WP_000093392.1 IS200/IS605 family transposase -
  A6V38_RS00185 (A6V38_00185) - 43399..43737 (+) 339 WP_000175892.1 SAUGI family uracil-DNA glycosylase inhibitor -
  A6V38_RS00195 (A6V38_00190) - 43831..44142 (+) 312 WP_001166716.1 DUF960 family protein -
  A6V38_RS00200 (A6V38_00195) - 44158..44664 (+) 507 WP_000848380.1 DUF1643 domain-containing protein -
  A6V38_RS00205 (A6V38_00200) - 44685..45002 (+) 318 WP_000659046.1 JAB domain-containing protein -
  A6V38_RS00210 (A6V38_00205) - 45121..46206 (+) 1086 WP_000868132.1 tyrosine-type recombinase/integrase -
  A6V38_RS00215 (A6V38_00210) - 46203..48095 (+) 1893 Protein_37 site-specific integrase -
  A6V38_RS00220 (A6V38_00215) - 48102..48479 (+) 378 WP_000361059.1 DUF6262 family protein -
  A6V38_RS00225 (A6V38_16150) ant(9) 48630..49412 (+) 783 Protein_39 aminoglycoside nucleotidyltransferase ANT(9) -
  A6V38_RS00230 (A6V38_00230) erm(A) 49538..50269 (-) 732 WP_031863781.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) -
  A6V38_RS16345 (A6V38_16155) - 50352..50411 (-) 60 WP_010959190.1 erythromycin resistance leader peptide -
  A6V38_RS00245 (A6V38_00240) - 50803..51465 (+) 663 WP_001092058.1 class I SAM-dependent methyltransferase -
  A6V38_RS00250 (A6V38_00245) - 51697..51843 (+) 147 Protein_43 JAB domain-containing protein -
  A6V38_RS00255 (A6V38_00250) - 52013..52885 (+) 873 WP_000373151.1 HTH domain-containing protein -
  A6V38_RS00260 (A6V38_00255) - 52942..53232 (+) 291 WP_000065262.1 hypothetical protein -
  A6V38_RS00265 (A6V38_00260) - 53248..53736 (+) 489 WP_000397419.1 hypothetical protein -
  A6V38_RS00270 (A6V38_00265) - 53871..54398 (+) 528 WP_000717928.1 hypothetical protein -
  A6V38_RS00275 (A6V38_00270) - 54460..54876 (+) 417 WP_000941331.1 hypothetical protein -
  A6V38_RS16115 - 55165..55329 (+) 165 WP_001803222.1 hypothetical protein -
  A6V38_RS00280 (A6V38_00275) - 55343..55564 (+) 222 WP_001070883.1 hypothetical protein -
  A6V38_RS00285 (A6V38_00280) - 55714..56280 (+) 567 WP_000759939.1 PepSY domain-containing protein -
  A6V38_RS00290 (A6V38_00285) - 56360..58573 (-) 2214 Protein_52 type I restriction endonuclease subunit R -
  A6V38_RS00295 (A6V38_00290) - 58635..59309 (-) 675 WP_001105999.1 IS6-like element IS257 family transposase -
  A6V38_RS00300 (A6V38_00295) - 59592..60938 (+) 1347 WP_162564149.1 NAD(P)/FAD-dependent oxidoreductase -
  A6V38_RS00305 (A6V38_00300) merR 61238..61645 (+) 408 WP_000425271.1 Hg(II)-responsive transcriptional regulator MerR -
  A6V38_RS00310 (A6V38_00305) - 61662..62015 (+) 354 WP_110175111.1 TlpA disulfide reductase family protein -
  A6V38_RS00315 (A6V38_00315) - 62012..62692 (+) 681 WP_000010352.1 cytochrome c biogenesis CcdA family protein -
  A6V38_RS00320 (A6V38_00320) merT 62780..63166 (+) 387 WP_001794630.1 mercuric transport protein MerT -
  A6V38_RS00325 (A6V38_00325) merA 63224..64867 (+) 1644 WP_000193219.1 mercury(II) reductase -
  A6V38_RS00330 (A6V38_00330) merB 64949..65599 (+) 651 WP_000790333.1 organomercurial lyase MerB -
  A6V38_RS00340 (A6V38_00340) - 65794..66309 (-) 516 WP_000377078.1 hypothetical protein -
  A6V38_RS00345 (A6V38_00345) - 66428..67102 (-) 675 WP_001105988.1 IS6-like element IS257 family transposase -
  A6V38_RS16350 (A6V38_00350) - 67535..67867 (-) 333 WP_001803416.1 DUF3021 domain-containing protein -
  A6V38_RS00355 (A6V38_00355) - 67896..68138 (-) 243 WP_001803415.1 LytTR family DNA-binding domain-containing protein -
  A6V38_RS00360 (A6V38_00360) - 68270..68944 (-) 675 WP_001106055.1 IS6-like element IS257 family transposase -
  A6V38_RS00365 (A6V38_00365) tet(K) 69141..70520 (+) 1380 WP_000492283.1 tetracycline efflux MFS transporter Tet(K) -
  A6V38_RS00370 (A6V38_00370) mobV 70706..71947 (+) 1242 WP_000122374.1 MobV family relaxase -
  A6V38_RS00375 (A6V38_00375) - 72474..73428 (+) 955 Protein_68 replication initiation factor domain-containing protein -
  A6V38_RS00380 (A6V38_00380) - 73517..74191 (-) 675 WP_001106057.1 IS6-like element IS257 family transposase -
  A6V38_RS00385 (A6V38_00385) - 74227..74616 (+) 390 WP_020444595.1 hydroxymethylglutaryl-CoA synthase -
  A6V38_RS00395 (A6V38_00395) - 75493..76236 (+) 744 WP_000958858.1 glycerophosphoryl diester phosphodiesterase -
  A6V38_RS00400 (A6V38_00400) - 76333..76761 (+) 429 WP_000872606.1 MaoC family dehydratase -
  A6V38_RS00405 (A6V38_00405) mecA 76807..78816 (-) 2010 WP_078056515.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  A6V38_RS00410 (A6V38_00410) mecR1 78913..80670 (+) 1758 WP_000952923.1 beta-lactam sensor/signal transducer MecR1 -
  A6V38_RS00415 (A6V38_00415) mecI 80670..81041 (+) 372 Protein_75 mecA-type methicillin resistance repressor MecI -
  A6V38_RS00420 (A6V38_16165) psm-mec 81126..81194 (-) 69 WP_014532405.1 phenol-soluble modulin PSM-mec -
  A6V38_RS00425 (A6V38_00430) - 81514..82662 (+) 1149 WP_000427807.1 ROK family transcriptional regulator -
  A6V38_RS00435 (A6V38_00435) cstB 82776..84110 (-) 1335 Protein_78 persulfide dioxygenase-sulfurtransferase CstB -
  A6V38_RS00440 (A6V38_00440) - 84142..85206 (-) 1065 WP_000438836.1 DsrE/DsrF/DrsH-like family protein -
  A6V38_RS00445 (A6V38_00445) cstR 85342..85602 (+) 261 WP_000220507.1 persulfide-sensing transcriptional repressor CstR -
  A6V38_RS00450 (A6V38_00450) - 85602..86240 (+) 639 Protein_81 sulfite exporter TauE/SafE family protein -
  A6V38_RS00460 (A6V38_00460) - 86514..87131 (-) 618 WP_000562107.1 CadD family cadmium resistance transporter -
  A6V38_RS00465 (A6V38_00465) - 87212..89626 (-) 2415 WP_000378485.1 cadmium-translocating P-type ATPase CadA -
  A6V38_RS00470 (A6V38_00470) - 89619..89984 (-) 366 WP_000159127.1 metalloregulator ArsR/SmtB family transcription factor -
  A6V38_RS00475 (A6V38_00475) - 90170..90547 (-) 378 WP_001041908.1 DUF6262 family protein -
  A6V38_RS00480 (A6V38_00480) - 90554..92446 (-) 1893 WP_072387024.1 site-specific integrase -
  A6V38_RS00485 (A6V38_00485) - 92641..92964 (-) 324 WP_000088091.1 JAB domain-containing protein -
  A6V38_RS00490 (A6V38_00490) - 92957..93163 (-) 207 WP_001077283.1 hypothetical protein -
  A6V38_RS00495 (A6V38_00495) - 93165..93686 (-) 522 WP_000836008.1 DUF1643 domain-containing protein -
  A6V38_RS00500 (A6V38_00500) - 93705..94016 (-) 312 WP_000833212.1 DUF960 family protein -
  A6V38_RS00510 (A6V38_00505) - 94101..94451 (-) 351 WP_000171449.1 SAUGI family uracil-DNA glycosylase inhibitor -
  A6V38_RS00515 (A6V38_00510) ccrB 94922..96550 (-) 1629 WP_001186596.1 cassette chromosome recombinase CcrB Machinery gene
  A6V38_RS00520 (A6V38_00515) ccrA 96571..97917 (-) 1347 WP_000816499.1 cassette chromosome recombinase CcrA Machinery gene

Sequence

Protein


Download         Length: 542 a.a.        Molecular weight: 62274.15 Da        Isoelectric Point: 9.7334

>NTDB_id=179906 A6V38_RS00515 WP_001186596.1 94922..96550(-) (ccrB) [Staphylococcus aureus strain M92]
MQQLKQKRVGIYVRVSTEIQSTEGYSIDGQINQIREYCDFNNFVVVDVYADRGISGKSMNRPELQRLLKDANEGQIDSVM
VYKTNRLARNTSDLLKIVEDLHRQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSIGSVTYILSNPFYVGKIQFAK
YKDWNEKRRKGLNDKPIIAEGKHSPIIIQDLWDKVQLRKKQVSQKPQVHGKGTNLLTGIVHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEKYVMDQILEIVKSDKVINQVLERVNQENKVDIGALNHDIAYKQQQYD
EVSGKLHNLVKTIEDNPDLTSALKATIHQYETQLNDITNQMNQLKQQQNQEKLSYDTKQIAALLQRIFQNIESMDKAQLK
ALYLTVIDRIDIRKDGNHKKQFYVTLKLNNEIIKQLFNNTPLDEVLLSTSSLFLPQTLFLQI

Nucleotide


Download         Length: 1629 bp        

>NTDB_id=179906 A6V38_RS00515 WP_001186596.1 94922..96550(-) (ccrB) [Staphylococcus aureus strain M92]
ATGCAACAACTCAAACAAAAACGTGTCGGTATCTATGTTCGTGTATCAACGGAAATCCAAAGTACTGAAGGCTATAGTAT
CGATGGACAAATCAATCAAATTCGAGAATATTGTGATTTCAATAACTTTGTTGTTGTAGATGTATACGCGGATAGAGGTA
TCTCTGGAAAATCTATGAACCGACCAGAACTACAACGTTTGTTAAAAGATGCGAACGAAGGTCAGATTGATTCTGTTATG
GTCTACAAAACAAACCGACTAGCACGTAACACTTCTGACTTACTCAAAATTGTTGAAGACCTTCATCGTCAAAATGTCGA
ATTCTTCAGCTTATCTGAGCGTATGGAAGTCAATACAAGCAGTGGTAAATTGATGCTACAAATTCTAGCGAGTTTTTCAG
AATTTGAAAGAAATAATATTGTCGAAAATGTATTCATGGGTCAAACCCGACGCGCTCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCGGATAGCAAGCATGAACTCATGATAAACCAACATGAAGCGAATATTGTCAAATA
TATATTTGAGTCATATGCTAAAGGCCACGGATATCGTAAAATTGCGAATGCACTCAATCACAAAGGATACGTGACTAAAA
AAGGAAAGCCTTTCAGTATTGGTTCAGTGACCTATATCTTATCTAATCCATTCTATGTTGGTAAAATTCAATTCGCAAAG
TACAAAGATTGGAATGAAAAGCGTCGTAAAGGGCTGAATGATAAACCAATAATAGCTGAAGGTAAGCATTCCCCTATTAT
TATTCAAGACTTATGGGATAAAGTCCAATTACGTAAAAAACAAGTCAGTCAAAAACCTCAAGTCCACGGTAAAGGAACTA
ATCTATTAACAGGTATCGTTCATTGTCCACAATGTGGTGCACCAATGGCAGCTAGTAACACAACGAACACATTGAAAGAT
GGTACCAAGAAGCGAATACGTTATTATTCTTGCAGTAACTTCCGAAACAAAGGCTCAAAAGTATGTTCTGCGAATAGCGT
TAGAGCTGATGTGATTGAAAAATACGTCATGGATCAAATACTCGAAATTGTCAAAAGTGATAAAGTCATTAACCAAGTCT
TAGAACGTGTCAATCAAGAAAATAAAGTCGATATTGGTGCATTGAACCACGATATCGCTTATAAACAACAACAATACGAT
GAAGTCAGCGGGAAACTCCATAATTTAGTTAAAACCATTGAAGATAATCCGGACCTAACATCTGCATTGAAAGCAACTAT
TCATCAATATGAAACACAACTCAATGACATTACAAATCAAATGAATCAACTCAAACAGCAACAAAATCAAGAGAAACTAT
CTTATGATACGAAACAAATCGCTGCCCTATTACAACGAATATTTCAAAATATAGAATCAATGGATAAAGCACAACTCAAA
GCATTATATCTTACAGTCATTGACCGTATTGATATTCGTAAAGACGGTAATCATAAAAAACAGTTCTACGTTACACTAAA
ACTCAATAATGAAATTATTAAACAACTTTTCAATAATACCCCTCTCGACGAAGTGCTCCTCAGCACTTCGTCTTTATTTT
TGCCTCAAACGCTCTTTCTTCAAATCTAA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(11-156)

Recombinase (Recombinase)

(180-280)

Ogr/Delta-like zinc finger (Ogr_Delta)

(301-356)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrB Staphylococcus aureus N315

86.531

100

0.865

Multiple sequence alignment