Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   A0O21_RS07205 Genome accession   NZ_CP014699
Coordinates   1566988..1568886 (-) Length   632 a.a.
NCBI ID   WP_067063575.1    Uniprot ID   A0A172Q8U4
Organism   Streptococcus pantholopis strain TA 26     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1561988..1573886
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A0O21_RS07185 (A0O21_07185) - 1563267..1563908 (-) 642 WP_067063562.1 response regulator transcription factor -
  A0O21_RS07195 (A0O21_07195) - 1565193..1566182 (-) 990 WP_067063568.1 sensor histidine kinase -
  A0O21_RS07200 (A0O21_07200) liaF 1566179..1566877 (-) 699 WP_067063571.1 cell wall-active antibiotics response protein LiaF -
  A0O21_RS07205 (A0O21_07205) pknB 1566988..1568886 (-) 1899 WP_067063575.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  A0O21_RS07210 (A0O21_07210) - 1568886..1569623 (-) 738 WP_067063578.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  A0O21_RS07215 (A0O21_07215) rsmB 1569660..1570982 (-) 1323 WP_067065225.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  A0O21_RS07220 (A0O21_07220) fmt 1570978..1571910 (-) 933 WP_067063581.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 632 a.a.        Molecular weight: 68474.31 Da        Isoelectric Point: 4.6190

>NTDB_id=173364 A0O21_RS07205 WP_067063575.1 1566988..1568886(-) (pknB) [Streptococcus pantholopis strain TA 26]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEEVAIKVLRTNYQTDQVAVTRFQREARAMAELNHPNIVAIRDIG
EEDGQQFLVMEYVEGSDLKKYIQEHAPLSNNEVVRIMEEVLSAMTLAHQQGIVHRDLKPQNILLTKNGTVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIGLNKNVP
QALENVVIKATAKRLSDRYSSTFEMSRDLMTALSYNRSREPKLVFNDHENTKTLPKVVPEPSAVTAEADEKESSAVQNAS
TAADTKGSSPNKKKKAKKQKRLLGTVAKIAFAVFAVALAWLAFVILRNPSTVSVPDVTGSTLAAAKKTIENSGLEVGDVH
KIESTTVDRGKVVRTDPAAGSSKKEGTRVDIYVSTGNSAFTMEDYTGQNYKEAMASLTENYGVSSSQIEIKEVAAGDYYD
EDTIVSQTPAAGETFNTAGDDKIRFEVASSNTVTMPDLTDYTYGDALDMLTGLGISTSRIKTYTNDYTEITSPSLTAVIS
SQSPEAGYEIVLSGNDDIILYLYSSQSGDYSERSSSSSDGSSSSSDSTEEEPEESSDGSSSSPDDSSSESSN

Nucleotide


Download         Length: 1899 bp        

>NTDB_id=173364 A0O21_RS07205 WP_067063575.1 1566988..1568886(-) (pknB) [Streptococcus pantholopis strain TA 26]
ATGATTCAGATTGGCAAATTGTTCGCTGGTCGTTATCGTATTTTGAAATCCATTGGACGGGGCGGGATGGCAGATGTTTA
TTTAGCCAATGACTTGATTTTAGATAATGAAGAAGTTGCTATAAAAGTACTGAGGACAAATTATCAGACGGATCAGGTTG
CTGTAACGCGTTTCCAGAGAGAAGCGCGAGCTATGGCTGAATTGAATCATCCTAATATTGTTGCAATTCGCGATATTGGA
GAAGAAGACGGCCAGCAATTTTTAGTAATGGAATATGTTGAAGGGTCCGACCTAAAAAAATATATCCAAGAGCACGCTCC
TTTATCAAATAATGAAGTTGTCAGGATTATGGAAGAAGTGCTTTCTGCCATGACACTGGCCCATCAGCAGGGGATTGTTC
ACCGGGATCTTAAACCTCAAAATATTTTACTGACCAAAAACGGAACTGTAAAAGTTACTGATTTTGGAATTGCCGTTGCC
TTTGCTGAAACAAGTTTGACACAGACCAATTCAATGCTAGGGAGTGTGCATTATTTGTCGCCTGAACAAGCCCGCGGTTC
TAAAGCCACGGTTCAAAGTGACATCTATGCTATGGGCATCATGCTCTTTGAAATGTTAACAGGCCATATTCCCTATGATG
GGGACAGCGCTGTTACCATTGCACTGCAGCATTTCCAAAAACCGCTTCCGTCAATTATTGGACTGAATAAAAATGTCCCC
CAGGCTCTTGAAAATGTCGTTATTAAGGCTACTGCGAAACGGCTGAGTGATCGTTATTCTTCAACTTTTGAGATGAGCCG
GGACCTAATGACAGCTCTCAGTTATAATCGCAGCCGCGAACCCAAGTTAGTTTTTAACGACCACGAAAATACGAAGACCT
TACCTAAAGTGGTTCCGGAACCTTCTGCTGTCACTGCAGAAGCAGATGAAAAAGAAAGCAGTGCTGTTCAAAATGCGAGT
ACAGCAGCAGATACTAAAGGGAGCAGTCCTAATAAAAAGAAGAAAGCGAAAAAGCAGAAACGACTTCTTGGTACAGTGGC
CAAGATTGCCTTTGCTGTTTTTGCTGTTGCTTTGGCCTGGCTGGCCTTTGTCATTCTGCGCAATCCATCTACAGTAAGTG
TTCCTGATGTGACCGGTTCGACACTAGCTGCTGCCAAGAAGACAATTGAAAATTCAGGCCTGGAGGTAGGCGATGTTCAT
AAGATAGAAAGTACAACTGTGGACAGAGGCAAGGTTGTTCGGACTGATCCGGCCGCCGGTTCATCAAAGAAGGAAGGAAC
GCGTGTTGATATTTATGTGTCGACCGGCAATTCGGCCTTTACAATGGAAGATTATACCGGTCAGAATTATAAGGAGGCTA
TGGCCAGTCTGACAGAGAACTATGGCGTATCGTCATCGCAGATTGAAATCAAGGAGGTTGCAGCAGGAGACTATTATGAT
GAAGATACGATAGTCAGCCAAACTCCAGCAGCCGGTGAGACCTTCAATACTGCCGGTGATGATAAGATTAGGTTTGAAGT
GGCCAGCAGCAATACTGTAACGATGCCTGATTTAACTGACTATACCTATGGCGATGCTCTTGATATGCTGACAGGTTTGG
GTATTTCGACTTCACGCATTAAGACATATACTAATGATTATACCGAAATTACCTCTCCATCACTTACAGCTGTCATCAGC
AGCCAGAGTCCGGAGGCCGGTTATGAAATTGTCCTCTCCGGAAATGATGACATTATCCTCTATCTATATTCTTCTCAAAG
CGGGGATTATTCAGAAAGATCCTCTTCATCTTCAGATGGTTCGTCTTCAAGCAGTGATTCGACTGAAGAAGAACCAGAAG
AAAGTTCAGATGGTTCGTCTTCAAGTCCGGATGATTCTTCATCTGAATCATCAAATTAG

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-247)

PASTA domain (PASTA)

(441-508)

PASTA domain (PASTA)

(513-583)

PASTA domain (PASTA)

(372-435)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A172Q8U4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

67.466

92.405

0.623
  stkP/pknB Streptococcus salivarius strain HSISS4

60.535

94.62

0.573
  stkP Streptococcus pneumoniae TIGR4

57.39

82.437

0.473
  stkP Streptococcus pneumoniae D39

57.198

82.437

0.472
  stkP Streptococcus pneumoniae R6

57.198

82.437

0.472
  stkP Streptococcus pneumoniae Rx1

57.006

82.437

0.47

Multiple sequence alignment