Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   BMJ42_RS02590 Genome accession   NZ_CP018136
Coordinates   439308..439940 (+) Length   210 a.a.
NCBI ID   WP_000698434.1    Uniprot ID   Q9S1J7
Organism   Streptococcus pneumoniae strain SP49     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 434308..444940
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  BMJ42_RS02565 (BMJ42_00484) mvaD 434585..435538 (+) 954 WP_000373457.1 diphosphomevalonate decarboxylase -
  BMJ42_RS02570 (BMJ42_00485) - 435525..436532 (+) 1008 WP_073176705.1 phosphomevalonate kinase -
  BMJ42_RS02575 (BMJ42_00486) fni 436516..437526 (+) 1011 WP_000210620.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  BMJ42_RS02580 (BMJ42_00487) liaF 437604..438302 (+) 699 WP_001224640.1 cell wall-active antibiotics response protein LiaF -
  BMJ42_RS02585 (BMJ42_00488) - 438299..439294 (+) 996 WP_050202567.1 sensor histidine kinase -
  BMJ42_RS02590 (BMJ42_00489) vraR 439308..439940 (+) 633 WP_000698434.1 response regulator transcription factor Regulator
  BMJ42_RS02600 - 439941..440332 (+) 392 Protein_483 DNA alkylation repair protein -
  BMJ42_RS13700 - 440447..440591 (+) 145 Protein_484 DNA alkylation repair protein -
  BMJ42_RS02615 (BMJ42_00491) - 441050..441652 (+) 603 Protein_485 trypsin-like serine peptidase -
  BMJ42_RS02620 - 442008..442313 (+) 306 WP_000889974.1 tyrosine-type recombinase/integrase -
  BMJ42_RS02625 (BMJ42_00492) tig 442507..443790 (+) 1284 WP_000116474.1 trigger factor -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23553.03 Da        Isoelectric Point: 4.5791

>NTDB_id=172756 BMJ42_RS02590 WP_000698434.1 439308..439940(+) (vraR) [Streptococcus pneumoniae strain SP49]
MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALELRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIV
TSYLDNEKIMPVLDAGAKGYMLKTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGQEEF

Nucleotide


Download         Length: 633 bp        

>NTDB_id=172756 BMJ42_RS02590 WP_000698434.1 439308..439940(+) (vraR) [Streptococcus pneumoniae strain SP49]
ATGAAAATTTTACTAGTAGATGACCATGAAATGGTCCGATTGGGCTTGAAAAGCTACTTTGACCTCCAAGACGATGTAGA
AGTTGTGGGTGAGGCGTCCAACGGGTCTCAAGGGATTGACTTGGCCTTGGAACTGCGTCCAGATGTCATTGTCATGGATA
TTGTCATGCCTGAGATGAATGGGATTGACGCGACCTTAGCAATCCTTAAAGAATGGCCTGAAGCCAAGATTTTGATTGTG
ACCTCTTATTTGGACAATGAAAAAATCATGCCAGTCTTAGATGCTGGTGCCAAAGGCTATATGCTCAAGACTTCTAGTGC
AGATGAATTGCTTCATGCCGTCAGTAAGGTAGCTGCTGGCGAGCTGGCCATTGAGCAAGAGGTTAGCAAGAAGGTTGAAT
ACCACCGCAATCATATGGAACTTCATGAAGAATTGACTGCGCGTGAGCGAGATGTTCTCCAACTCATCGCCAAGGGCTAC
GAAAATCAGCGCATCGCAGATGACCTCTTTATCTCTCTCAAGACGGTCAAGACCCACGTGTCCAATATTCTTGCCAAACT
TGAAGTCAGCGATCGTACCCAGGCGGCTGTCTATGCCTTTCAGCACCATTTGGTGGGGCAAGAGGAGTTTTAG

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(145-199)

Response regulator receiver domain (Response_reg)

(3-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1J7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.153

99.524

0.519
  degU Bacillus subtilis subsp. subtilis str. 168

38.393

100

0.41