Detailed information NTG0172241

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: BMR72_RS12035
• Genome accession: NZ_CP017969
• Coordinates: 2428897..2431173 (+)
• Length: 758 a.a.
• NCBI ID: WP_003090432.1
• Uniprot ID: A0A0H2ZAW8
• Organism: Pseudomonas aeruginosa isolate B10W
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 2423897..2436173

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BMR72_RS12015 (BMR72_11635)	-	2424090..2426315 (-)	2226	WP_003122606.1	NADP-dependent isocitrate dehydrogenase	-
BMR72_RS12020 (BMR72_11640)	icd	2426674..2427930 (+)	1257	WP_003090436.1	NADP-dependent isocitrate dehydrogenase	-
BMR72_RS12025 (BMR72_11645)	cspD	2428003..2428275 (-)	273	WP_003090435.1	cold shock domain-containing protein CspD	-
BMR72_RS12030 (BMR72_11650)	clpS	2428501..2428869 (+)	369	WP_003097649.1	ATP-dependent Clp protease adapter ClpS	-
BMR72_RS12035 (BMR72_11655)	clpC	2428897..2431173 (+)	2277	WP_003090432.1	ATP-dependent Clp protease ATP-binding subunit ClpA	Regulator
BMR72_RS12040 (BMR72_11660)	infA	2431255..2431473 (-)	219	WP_002553999.1	translation initiation factor IF-1	-
BMR72_RS12045 (BMR72_11665)	-	2431578..2432285 (-)	708	WP_003108766.1	arginyltransferase	-
BMR72_RS12050 (BMR72_11670)	aat	2432340..2433020 (-)	681	WP_003131120.1	leucyl/phenylalanyl-tRNA--protein transferase	-
BMR72_RS12055 (BMR72_11675)	trxB	2433058..2434008 (-)	951	WP_003090421.1	thioredoxin-disulfide reductase	-

Sequence

Protein

• Length: 758 a.a.
• Molecular weight: 84010.68 Da
• Isoelectric Point: 5.8904

>NTDB_id=172241 BMR72_RS12035 WP_003090432.1 2428897..2431173(+) (clpC) [Pseudomonas aeruginosa isolate B10W]
MLNRELEVTLNLAFKEARAKRHEFMTVEHLLLALLDNEAAATVLRACGANLDKLRRDLQEFIDSTTPLIPQHDDERETQP
TLGFQRVLQRAVFHVQSSGKREVTGANVLVAIFSEQESQAVFLLKQQSIARIDVVNYIAHGISKVPGHAEHPQDGEQDMQ
DEEGGESATSNHPLDAYASNLNELARQGRIDPLVGREHEVERVAQILARRRKNNPLLVGEAGVGKTAIAEGLAKRIVDGQ
VPDLLADSVVYSLDLGALLAGTKYRGDFEKRFKALLNELRKRPHAVLFIDEIHTIIGAGAASGGVMDASNLLKPVLSSGE
IRCIGSTTFQEFRGIFEKDRALARRFQKVDVTEPSVEDTYGILKGLKGRFEQHHHIEYSDEALRAAAELAARYINDRHMP
DKAIDVIDEAGAYQRLQPEEKRVKRIEVAQVEDIVAKIARIPPKHVTTSDKELLRNLERDLKLTVFGQDDAIESLSTAIK
LSRAGLKAPDKPVGSFLFAGPTGVGKTEVARQLAKALGVELVRFDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTEAITK
TPHCVLLLDEIEKAHPEVFNLLLQVMDHGTLTDNNGRKADFRNIILIMTTNAGAEVAARASIGFNQQDHTTDAMEVIKKS
FTPEFRNRLDTIIQFGRLSTETIKSVVDKFLTELQAQLEDKRVQLEVSDAARGWLAEKGYDVQMGARPMARLIQDKIKRP
LAEEILFGELAEHGGLVHVDLKGDELAFEFEITAAEPA

Nucleotide

• Length: 2277 bp

>NTDB_id=172241 BMR72_RS12035 WP_003090432.1 2428897..2431173(+) (clpC) [Pseudomonas aeruginosa isolate B10W]
ATGTTGAATCGAGAGCTCGAAGTCACCCTCAATCTCGCCTTCAAGGAGGCGAGGGCCAAACGCCATGAATTCATGACGGT
TGAGCACCTGCTGCTGGCCTTGCTGGACAATGAGGCGGCGGCAACGGTATTGCGTGCGTGCGGTGCCAACCTGGACAAGC
TGCGGCGCGACCTGCAGGAATTCATCGATTCCACCACGCCGCTGATCCCGCAGCACGACGACGAGCGCGAAACCCAGCCG
ACGCTGGGCTTCCAGCGCGTCCTGCAGCGTGCGGTGTTCCACGTGCAGAGTTCCGGCAAGCGCGAAGTGACCGGGGCCAA
TGTCCTGGTGGCGATCTTCAGCGAACAGGAAAGCCAGGCGGTGTTCCTGCTCAAGCAGCAGAGCATCGCGCGTATCGATG
TGGTGAACTACATCGCCCACGGCATCTCCAAGGTGCCCGGGCATGCCGAACATCCGCAGGATGGGGAGCAGGATATGCAG
GATGAGGAAGGTGGCGAGTCGGCCACGTCCAACCATCCGCTGGACGCCTATGCCAGCAACCTCAACGAACTGGCTCGCCA
GGGGCGGATCGACCCGCTGGTGGGGCGCGAGCATGAAGTCGAGCGGGTGGCGCAGATCCTTGCCCGCCGGCGCAAGAACA
ACCCGCTGCTGGTAGGCGAGGCGGGGGTCGGCAAGACTGCCATCGCCGAAGGCCTGGCCAAGCGCATCGTCGATGGCCAG
GTGCCGGACCTGCTGGCCGACAGCGTGGTCTACTCCCTCGACCTGGGTGCCTTGCTCGCGGGTACCAAGTACCGCGGCGA
CTTCGAGAAGCGCTTCAAGGCCTTGCTCAACGAGTTGCGCAAGCGCCCGCACGCGGTGCTGTTCATCGACGAGATCCATA
CCATCATCGGCGCCGGTGCGGCATCCGGCGGGGTAATGGACGCCTCCAACCTGCTCAAGCCGGTCTTGTCCTCGGGCGAG
ATCCGCTGCATCGGCTCGACCACCTTCCAGGAGTTCCGCGGCATCTTCGAGAAGGACCGGGCCTTGGCGCGGCGCTTCCA
GAAGGTCGACGTGACCGAGCCGTCGGTGGAAGATACCTATGGCATCCTCAAGGGCCTCAAGGGGCGCTTCGAGCAGCATC
ACCACATCGAGTACAGCGACGAGGCGCTGCGCGCCGCGGCCGAGCTGGCGGCGCGCTATATCAACGACCGGCACATGCCG
GACAAGGCCATCGACGTCATCGACGAGGCGGGCGCCTACCAGCGCCTGCAGCCGGAAGAGAAGCGCGTGAAGCGCATCGA
GGTGGCGCAGGTCGAGGATATCGTGGCGAAGATCGCGCGGATCCCGCCGAAACACGTCACCACCTCCGACAAGGAGTTGC
TGCGCAACCTCGAGCGCGACCTCAAGCTGACCGTGTTCGGCCAGGACGACGCCATCGAGTCGCTGTCCACGGCGATCAAG
CTGTCCCGGGCCGGGCTCAAGGCGCCGGACAAGCCGGTCGGCTCGTTCCTCTTCGCCGGTCCCACCGGCGTGGGCAAGAC
CGAGGTGGCGCGGCAGTTGGCGAAGGCCTTGGGCGTGGAGCTGGTGCGCTTCGACATGTCCGAGTACATGGAGCGGCATA
CCGTGTCGCGGCTGATCGGTGCGCCTCCGGGCTACGTCGGCTTCGACCAGGGCGGCCTGCTCACCGAGGCGATCACCAAG
ACCCCGCACTGCGTGTTGCTGCTCGACGAGATCGAGAAGGCTCACCCGGAGGTCTTCAACCTGCTGCTGCAGGTGATGGA
CCACGGCACCCTGACCGACAACAACGGGCGCAAGGCGGACTTCCGCAACATCATCCTGATCATGACCACCAACGCCGGCG
CGGAAGTGGCGGCGCGCGCGTCGATCGGCTTCAACCAGCAGGATCACACCACCGATGCGATGGAAGTGATCAAGAAGAGC
TTCACCCCGGAGTTCCGCAACCGCCTGGATACCATCATCCAGTTCGGCCGCCTGAGCACCGAGACGATCAAGAGCGTGGT
CGACAAGTTCCTCACCGAGCTGCAGGCGCAGCTGGAGGACAAGCGCGTCCAGCTCGAGGTCAGCGATGCGGCGCGCGGCT
GGCTGGCGGAGAAGGGCTACGACGTGCAGATGGGTGCGCGACCGATGGCGCGGCTTATCCAGGACAAGATCAAGCGGCCG
TTGGCCGAGGAGATCCTGTTCGGCGAGCTGGCCGAGCATGGCGGCCTGGTGCATGTCGACCTGAAGGGCGACGAGCTGGC
CTTCGAGTTCGAGATCACGGCGGCGGAGCCCGCCTGA

Domains

Predicted by InterProScan.

• ATPase family associated with various cellular activities (AAA) (AAA) (216-328)

• AAA lid domain (AAA_lid_9) (355-458)

• AAA domain (Cdc48 subfamily) (AAA_2) (491-652)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (13-62)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (658-739)

3D structure

• AlphaFold DB: A0A0H2ZAW8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	38.956	100	0.423
clpA	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	41.667	96.57	0.402
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	37.247	100	0.389
clpC	Streptococcus mutans UA159	45.484	81.794	0.372
clpC	Lactococcus lactis subsp. cremoris KW2	44.586	82.85	0.369