Detailed information NTG0169985

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: AXE83_RS02470
• Genome accession: NZ_CP014264
• Coordinates: 522406..523143 (+)
• Length: 245 a.a.
• NCBI ID: WP_060955292.1
• Uniprot ID: A0A0X8JX24
• Organism: Streptococcus sp. oral taxon 431 strain F0610 (5-114)
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 517406..528143

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AXE83_RS02435 (AXE83_02435)	-	518006..518659 (-)	654	WP_083500974.1	hypothetical protein	-
AXE83_RS02440 (AXE83_02440)	-	518744..519031 (-)	288	WP_045763640.1	hypothetical protein	-
AXE83_RS02445 (AXE83_02445)	-	519041..519451 (-)	411	WP_060955288.1	HIT family protein	-
AXE83_RS02450 (AXE83_02450)	pptA	519519..520250 (+)	732	WP_060955289.1	ABC transporter ATP-binding protein	Regulator
AXE83_RS02455 (AXE83_02455)	pptB	520247..521296 (+)	1050	WP_060955290.1	ABC transporter permease	Regulator
AXE83_RS02460 (AXE83_02460)	-	521453..521782 (-)	330	WP_060955291.1	hypothetical protein	-
AXE83_RS02465 (AXE83_02465)	-	522063..522401 (+)	339	WP_049504297.1	LytTR family DNA-binding domain-containing protein	-
AXE83_RS02470 (AXE83_02470)	comE/blpR	522406..523143 (+)	738	WP_060955292.1	LytTR family DNA-binding domain-containing protein	Regulator
AXE83_RS02475 (AXE83_02475)	-	523157..524506 (+)	1350	WP_060955293.1	sensor histidine kinase	-
AXE83_RS02480 (AXE83_02480)	-	524608..524964 (+)	357	WP_060955294.1	hypothetical protein	-
AXE83_RS10930	-	525162..525314 (+)	153	WP_148130295.1	hypothetical protein	-
AXE83_RS02485 (AXE83_02485)	-	525311..525715 (+)	405	WP_060955295.1	hypothetical protein	-
AXE83_RS02490 (AXE83_02490)	-	526218..526820 (+)	603	WP_060955296.1	type II CAAX endopeptidase family protein	-
AXE83_RS02500 (AXE83_02500)	-	527150..527461 (+)	312	WP_060955298.1	hypothetical protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28750.00 Da
• Isoelectric Point: 6.5015

>NTDB_id=169985 AXE83_RS02470 WP_060955292.1 522406..523143(+) (comE/blpR) [Streptococcus sp. oral taxon 431 strain F0610 (5-114)]
MRIFVLEDDFSQQARIETTIEKLLKKQSIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALIYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVLKQEPRLLQCHRSFLINPTNVVRLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=169985 AXE83_RS02470 WP_060955292.1 522406..523143(+) (comE/blpR) [Streptococcus sp. oral taxon 431 strain F0610 (5-114)]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAAGCTAGGATTGAAACGACGATTGAAAAACTTTTGAAAAAACA
GAGTATCATCCCCAGTTCTTTTGAAGTCTTTGGCAAGCCAGACCAACTGCTGGCAGAGGTGCATGAAAAGGGGGCGCATC
AGCTTTTCTTTTTGGACATTGAGATTCGAAATGAAGAGATGAAGGGGCTAGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATCGTCTTTGTGACGACTCACTCAGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTATCGGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTTATCTATGCCAATAGTCAAGATA
GTAAAAGTTTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCTCAATTCCAGTATCCCTTTAAAGAGGTTTACTAT
CTCGAAACGTCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTGGAATTTACGGCGAGTTTAGAGGA
GGTTCTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTTATCAATCCAACTAATGTAGTTCGTTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTATCTGAGGCT
ATCAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A0A0X8JX24

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.909	99.184	0.535
comE/comE1	Streptococcus equinus JB1	43.038	96.735	0.416
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384