Detailed information NTG0168246

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: AL519_RS06215
• Genome accession: NZ_CP014064
• Coordinates: 1142398..1143441 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain FDAARGOS_159
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1137398..1148441

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AL519_RS06185 (AL519_06125)	-	1137819..1139075 (-)	1257	WP_001795108.1	aminopeptidase	-
AL519_RS06190 (AL519_06130)	-	1139078..1139278 (-)	201	WP_000180460.1	DUF1128 family protein	-
AL519_RS06195 (AL519_06135)	-	1139425..1139889 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
AL519_RS06200 (AL519_06140)	-	1139896..1140171 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
AL519_RS06205 (AL519_06145)	-	1140449..1141666 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
AL519_RS06210 (AL519_06150)	vraR	1141779..1142408 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
AL519_RS06215 (AL519_06155)	vraS	1142398..1143441 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
AL519_RS06220 (AL519_06160)	liaF	1143438..1144139 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
AL519_RS06225 (AL519_06165)	-	1144154..1144540 (-)	387	WP_001110179.1	hypothetical protein	-
AL519_RS06230 (AL519_06170)	map	1144757..1145515 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
AL519_RS06235 (AL519_06175)	-	1145987..1146973 (+)	987	WP_000999717.1	FUSC family protein	-
AL519_RS06245 (AL519_06180)	-	1147404..1147817 (-)	414	WP_001557448.1	hypothetical protein	-
AL519_RS06250 (AL519_06185)	-	1147846..1147956 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=168246 AL519_RS06215 WP_001017131.1 1142398..1143441(-) (vraS) [Staphylococcus aureus strain FDAARGOS_159]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=168246 AL519_RS06215 WP_001017131.1 1142398..1143441(-) (vraS) [Staphylococcus aureus strain FDAARGOS_159]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1