Detailed information NTG0163792

Bioinformatically predicted

Overview

• Name: clpX
• Type: Regulator
• Locus tag: AUQ45_RS03755
• Genome accession: NZ_CP013672
• Coordinates: 729279..730508 (+)
• Length: 409 a.a.
• NCBI ID: WP_002984948.1
• Uniprot ID: A0A4U7GJW1
• Organism: Streptococcus pyogenes strain AP53
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 724279..735508

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AUQ45_RS03735 (AUQ45_0730)	-	724895..726172 (-)	1278	WP_002984963.1	hydroxymethylglutaryl-CoA reductase, degradative	-
AUQ45_RS03740 (AUQ45_0731)	-	726159..727334 (-)	1176	WP_002993959.1	hydroxymethylglutaryl-CoA synthase	-
AUQ45_RS03745 (AUQ45_0732)	-	727543..728382 (+)	840	WP_010922172.1	thymidylate synthase	-
AUQ45_RS03750 (AUQ45_0733)	-	728462..728959 (+)	498	WP_014635412.1	dihydrofolate reductase	-
AUQ45_RS09965 (AUQ45_0734)	-	728979..729149 (+)	171	WP_002984950.1	hypothetical protein	-
AUQ45_RS03755 (AUQ45_0735)	clpX	729279..730508 (+)	1230	WP_002984948.1	ATP-dependent Clp protease ATP-binding subunit ClpX	Regulator
AUQ45_RS03760 (AUQ45_0736)	yihA	730518..731117 (+)	600	WP_002984945.1	ribosome biogenesis GTP-binding protein YihA/YsxC	-
AUQ45_RS03765 (AUQ45_0737)	-	731265..732008 (+)	744	WP_002984942.1	hypothetical protein	-
AUQ45_RS03770 (AUQ45_0738)	-	732066..734165 (-)	2100	WP_014635413.1	AAA family ATPase	-
AUQ45_RS03775 (AUQ45_0739)	rpiA	734543..735226 (+)	684	WP_014635414.1	ribose-5-phosphate isomerase RpiA	-

Sequence

Protein

• Length: 409 a.a.
• Molecular weight: 44991.44 Da
• Isoelectric Point: 4.5775

>NTDB_id=163792 AUQ45_RS03755 WP_002984948.1 729279..730508(+) (clpX) [Streptococcus pyogenes strain AP53]
MAGSRTNDIKVYCSFCGKSQDDVKKIIAGNNVFICNECVALSQEIIKEELAEEVLADLTEVPKPKELLDVLNQYVVGQDR
AKRALSVAVYNHYKRVSFTESRDDDDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENI
LLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTK
NILFIVGGAFDGIEEIVKQRLGEKVIGFGQNSRKIDDNASYMQEIISEDIQKFGLIPEFIGRLPVVAALEQLNTSDLIQI
LTEPRNALVKQYQALLSYDGVELAFDKEALEAIANKAIERKTGARGLRSIIEETMLDIMFEIPSQEDVTKVRITKAAVEG
KSKPVLETA

Nucleotide

• Length: 1230 bp

>NTDB_id=163792 AUQ45_RS03755 WP_002984948.1 729279..730508(+) (clpX) [Streptococcus pyogenes strain AP53]
ATGGCAGGAAGTAGAACTAACGATATTAAAGTATACTGTTCATTTTGTGGTAAAAGCCAGGATGACGTTAAAAAAATTAT
CGCAGGAAATAATGTTTTCATCTGCAATGAATGCGTAGCTTTATCACAAGAAATTATAAAAGAAGAATTGGCTGAAGAAG
TCCTTGCCGATTTGACAGAAGTTCCAAAACCAAAAGAGCTCCTTGATGTTTTAAATCAATATGTGGTTGGTCAAGATCGT
GCTAAACGTGCTTTATCAGTTGCTGTGTACAATCATTATAAGCGTGTCTCGTTTACAGAAAGTCGTGATGACGATGATGT
GGATTTACAAAAGTCCAACATTTTGATGATTGGACCAACAGGTTCAGGAAAAACCTTCTTAGCACAAACTCTGGCTAAAA
GCCTCAATGTACCATTTGCTATTGCAGATGCAACTTCTTTGACTGAAGCAGGGTATGTTGGAGAAGATGTGGAAAATATT
TTACTCAAACTGATTCAGGCTGCTGACTATAATGTCGAACGAGCAGAGCGTGGTATTATTTATGTTGATGAAATAGATAA
GATTGCTAAAAAAGGTGAGAACGTATCTATCACACGTGATGTATCTGGTGAAGGTGTACAGCAAGCCCTTCTTAAAATTA
TTGAAGGTACGGTAGCAAGTGTTCCCCCACAAGGTGGGCGGAAGCACCCTAATCAAGAAATGATCCAAATTGATACAAAA
AATATCTTGTTTATTGTTGGCGGGGCTTTTGATGGCATCGAGGAGATCGTTAAACAACGTTTAGGTGAAAAAGTTATTGG
TTTTGGTCAAAACAGCCGTAAAATTGATGACAATGCTTCTTATATGCAAGAAATTATTTCAGAAGATATTCAAAAGTTTG
GGCTTATTCCAGAATTTATTGGCCGCTTACCAGTTGTGGCAGCCCTTGAACAACTAAACACATCAGATTTGATTCAAATT
TTGACAGAACCAAGAAATGCCCTGGTCAAGCAATATCAGGCTCTTCTTTCTTACGATGGCGTCGAATTGGCATTTGATAA
GGAAGCCTTAGAAGCCATTGCCAATAAAGCCATTGAACGTAAGACAGGAGCACGTGGTCTTCGTTCTATTATCGAAGAAA
CGATGCTTGACATCATGTTTGAAATTCCAAGCCAAGAAGATGTCACAAAAGTGCGTATCACCAAGGCTGCTGTCGAAGGC
AAGTCAAAACCCGTTTTAGAGACAGCTTAA

Domains

Predicted by InterproScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (110-305)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (312-391)

• ClpX C4-type zinc finger (zf-C4_ClpX) (12-48)

3D structure

• AlphaFold DB: A0A4U7GJW1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpX	Streptococcus mutans UA159	88.998	100	0.89
clpX	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	58.603	98.044	0.575