Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   SAST42_RS09415 Genome accession   NZ_CP012976
Coordinates   1899756..1900385 (-) Length   209 a.a.
NCBI ID   WP_000153531.1    Uniprot ID   A0A481NSN8
Organism   Staphylococcus aureus strain ST20130942     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1894756..1905385
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SAST42_RS09385 (SAST42_03606) - 1895178..1895708 (-) 531 WP_000184383.1 acyl-CoA thioesterase -
  SAST42_RS09390 (SAST42_03607) - 1895797..1897053 (-) 1257 WP_001789555.1 aminopeptidase -
  SAST42_RS09395 (SAST42_01828) - 1897056..1897256 (-) 201 WP_000180460.1 DUF1128 family protein -
  SAST42_RS09400 (SAST42_01829) - 1897403..1897867 (+) 465 WP_000228666.1 low molecular weight protein-tyrosine-phosphatase -
  SAST42_RS09405 (SAST42_01830) - 1897874..1898149 (+) 276 WP_000428172.1 YtxH domain-containing protein -
  SAST42_RS09410 (SAST42_01832) - 1898427..1899644 (+) 1218 WP_000037079.1 YihY/virulence factor BrkB family protein -
  SAST42_RS09415 (SAST42_03608) vraR 1899756..1900385 (-) 630 WP_000153531.1 two-component system response regulator VraR Regulator
  SAST42_RS09420 (SAST42_01834) vraS 1900375..1901418 (-) 1044 WP_001017131.1 sensor histidine kinase Regulator
  SAST42_RS09425 (SAST42_03609) liaF 1901415..1902116 (-) 702 WP_000149064.1 cell wall-active antibiotics response protein LiaF -
  SAST42_RS09430 (SAST42_01836) - 1902131..1902517 (-) 387 WP_001110179.1 hypothetical protein -
  SAST42_RS09435 (SAST42_01837) map 1902734..1903492 (-) 759 WP_000636142.1 type I methionyl aminopeptidase -
  SAST42_RS09440 (SAST42_01838) - 1903964..1904950 (+) 987 WP_000999720.1 aromatic acid exporter family protein -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23471.17 Da        Isoelectric Point: 5.1621

>NTDB_id=158831 SAST42_RS09415 WP_000153531.1 1899756..1900385(-) (vraR) [Staphylococcus aureus strain ST20130942]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMEDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVHKTSSGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=158831 SAST42_RS09415 WP_000153531.1 1899756..1900385(-) (vraR) [Staphylococcus aureus strain ST20130942]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAGGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGAAGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCATAAAACTTCTAGCGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTCATCTATGCATTCCAACATAATTTAATTCAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-116)

Bacterial regulatory proteins, luxR family (GerE)

(147-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A481NSN8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

99.043

100

0.99
  degU Bacillus subtilis subsp. subtilis str. 168

34.821

100

0.373

Multiple sequence alignment