Detailed information    

insolico Bioinformatically predicted

Overview

Name   comB4   Type   Machinery gene
Locus tag   AA977_RS00100 Genome accession   NZ_CP011486
Coordinates   14286..16649 (+) Length   787 a.a.
NCBI ID   WP_064434104.1    Uniprot ID   A0A1A9HAD3
Organism   Helicobacter pylori strain K26A1     
Function   transformation-associated type IV transport system (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 9286..21649
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AA977_RS00070 (AA977_00075) groES 9310..9666 (-) 357 WP_064434100.1 co-chaperone GroES -
  AA977_RS00075 (AA977_00080) dnaG 9945..11624 (+) 1680 WP_064434101.1 DNA primase -
  AA977_RS00080 (AA977_00085) - 11621..12673 (+) 1053 WP_064434102.1 MnmA/TRMU family protein -
  AA977_RS00085 (AA977_00090) - 12766..13593 (+) 828 WP_064434103.1 DUF5718 family protein -
  AA977_RS00090 (AA977_00095) comB2 13740..14021 (+) 282 WP_020971705.1 TrbC/VirB2 family protein Machinery gene
  AA977_RS00095 (AA977_00100) comB3 14021..14284 (+) 264 WP_020971706.1 hypothetical protein Machinery gene
  AA977_RS00100 (AA977_00105) comB4 14286..16649 (+) 2364 WP_064434104.1 VirB4 family type IV secretion/conjugal transfer ATPase Machinery gene
  AA977_RS00110 (AA977_00110) - 16900..18288 (+) 1389 WP_253764842.1 COG3014 family protein -
  AA977_RS00115 (AA977_00115) cheV1 18388..19353 (+) 966 WP_064434106.1 chemotaxis protein CheV1 -
  AA977_RS00120 (AA977_00120) nspC 19350..20567 (+) 1218 WP_064434107.1 carboxynorspermidine decarboxylase -
  AA977_RS00125 (AA977_00125) lpxE 20596..21132 (-) 537 WP_253764843.1 lipid A 1-phosphatase LpxE -

Sequence

Protein


Download         Length: 787 a.a.        Molecular weight: 90289.03 Da        Isoelectric Point: 9.0343

>NTDB_id=146271 AA977_RS00100 WP_064434104.1 14286..16649(+) (comB4) [Helicobacter pylori strain K26A1]
MLEKLLNAVKQKISNYFLGVLPKSYSMSEENNILGLYDEHFLLTKNENLVGVLRLEGVSYTHLSTEQLQDLFTERQMALD
SLEKVVARIVVKRRKIDCKQNIQANSQHLQAILNQFENKEVYENQYFLVLESVHSLQGVLEHKKKSLMHANRENFKDILS
YKAHFLQETLRSLEIQLKNYAPKLLNSKEVLNFYAEYINGFELPLKPLVGGYLSDSYIASSVTFEKDYFIQESFNQKIYN
RLIGIKAYESERITSIAIGALLYQEMPLDIIFSIEPMSANKTLGFLKERAKFSMSHLVKNELLEYQELVKTKRLSMQKFA
LNILIKAPSLESLDTQTSLVLGLLFKENLVGVIETFGLKGGYFSFFPERIHLNHRLRFLTSKALACLMVFERQNLGFKAN
SWGDSPLSVFKNLDYSPFLFNFHNQEVSHKNAKEIPRVNGHTLIIGATGSGKSTLMSFLMMSALKYQNMRLLAFDRMQGL
YSFTEFFKGHYHDGKSFSINPFCLEPNLQNLEFLQSFFLSMFDLTPSRNKEALEDMNAVSSAIKSLYETLYPKAFSLLDF
KETLKRTSSNQLGLSLEPYLHNPLFNALNDAFNSNAFLNAINLDTITQNPKDLGLLAYYLFYKILEESRKNDSGFLVFLD
EFKSYVENDLLNTKINALITQARKANGVVVLALQDIYQLSGVKNAHSFLSNMGTLILYPQKNARELKNHFNVPLSETEIS
FLENTPLYARQVLVKNLGNGSSNMIDVSLEGLGRYLKIFNSDSSHVNKVKALQKDYPKEWREKLLKS

Nucleotide


Download         Length: 2364 bp        

>NTDB_id=146271 AA977_RS00100 WP_064434104.1 14286..16649(+) (comB4) [Helicobacter pylori strain K26A1]
ATGCTAGAGAAGCTTTTAAACGCTGTCAAACAAAAAATTTCAAACTATTTTTTAGGGGTTTTGCCTAAAAGCTATTCTAT
GAGCGAAGAAAATAATATTCTAGGCTTGTATGATGAGCATTTTTTACTCACTAAAAATGAAAACCTCGTTGGCGTCCTCC
GGTTAGAAGGGGTGAGTTACACCCATTTAAGCACAGAGCAATTGCAAGATCTTTTCACCGAGCGCCAAATGGCGTTGGAT
TCTTTAGAAAAAGTCGTGGCGCGAATCGTGGTTAAAAGGCGCAAAATTGATTGCAAGCAAAACATTCAAGCCAATTCCCA
ACACTTGCAAGCGATTTTAAACCAGTTTGAAAACAAAGAAGTGTATGAGAATCAGTATTTTTTAGTTTTAGAAAGCGTGC
ATTCCTTGCAAGGCGTTTTAGAGCATAAGAAAAAATCCTTAATGCATGCTAATAGGGAAAATTTTAAGGATATTCTCTCT
TATAAAGCGCATTTTTTGCAAGAAACTTTAAGAAGTTTAGAAATCCAACTCAAAAATTATGCCCCCAAACTCTTAAACTC
TAAAGAAGTGTTGAATTTTTACGCAGAATACATCAACGGGTTTGAGCTGCCTTTAAAGCCTTTAGTAGGGGGGTATTTGA
GCGATAGCTATATCGCTAGTTCTGTTACTTTTGAAAAAGATTATTTCATTCAAGAAAGCTTCAATCAAAAAATTTACAAC
CGCTTGATCGGCATTAAAGCTTATGAGAGCGAACGCATCACCTCCATAGCGATCGGAGCGCTTTTATACCAAGAGATGCC
CTTAGATATTATCTTTTCCATAGAGCCAATGAGCGCAAATAAAACGCTGGGTTTTTTAAAAGAAAGGGCTAAGTTTAGCA
TGTCTCATCTCGTTAAAAACGAGCTGTTAGAATACCAAGAATTAGTCAAAACCAAACGCTTATCCATGCAAAAATTCGCC
CTAAACATTCTTATTAAAGCCCCTAGTTTAGAAAGTTTAGACACTCAAACGAGCTTAGTTTTAGGGCTTTTGTTTAAAGA
AAACTTAGTGGGCGTTATAGAAACTTTTGGCTTGAAAGGAGGGTATTTTTCCTTTTTCCCTGAACGCATCCATTTAAACC
ACCGCTTGCGGTTTTTAACCTCTAAAGCTTTAGCGTGTTTGATGGTGTTTGAAAGGCAAAATTTAGGTTTTAAGGCCAAT
TCATGGGGGGATAGTCCTTTGAGCGTGTTTAAAAATTTGGATTATTCCCCTTTTTTATTCAATTTCCACAACCAAGAAGT
GAGCCACAAAAACGCCAAAGAAATCCCTAGGGTGAACGGGCATACGCTAATCATAGGGGCTACTGGGAGCGGTAAAAGCA
CGCTGATGAGCTTTTTAATGATGAGCGCTTTAAAATACCAAAACATGCGCCTTTTGGCCTTTGACAGGATGCAAGGGTTG
TATTCTTTCACAGAGTTTTTTAAAGGGCATTACCATGACGGCAAATCTTTTAGCATCAACCCCTTTTGTTTAGAGCCTAA
TTTGCAAAATTTAGAATTTTTGCAATCCTTCTTTTTGAGCATGTTTGATCTCACGCCCTCAAGGAATAAAGAAGCTTTAG
AAGACATGAATGCGGTTTCTAGTGCGATTAAAAGCCTTTATGAGACTTTATACCCAAAAGCTTTTAGTTTGCTAGATTTT
AAAGAAACGCTTAAAAGAACCTCATCTAACCAATTGGGTTTGAGTTTAGAGCCGTATTTGCATAACCCCCTTTTTAACGC
CTTAAATGATGCGTTCAATTCCAACGCTTTTTTAAATGCAATCAACCTAGACACCATCACTCAAAACCCTAAGGACTTAG
GGCTTTTAGCCTATTATTTGTTTTATAAAATCTTAGAAGAATCCAGGAAAAACGACAGCGGTTTTTTGGTTTTTTTAGAC
GAGTTTAAATCCTATGTGGAAAACGATTTATTGAACACTAAAATCAACGCTTTAATCACGCAAGCCAGAAAAGCTAATGG
CGTGGTGGTGTTAGCCTTGCAAGATATTTACCAATTGAGCGGGGTCAAAAACGCCCATAGCTTTTTAAGCAACATGGGGA
CTCTTATTTTGTATCCGCAAAAAAACGCCAGAGAATTGAAAAATCATTTCAATGTGCCTTTGAGCGAGACTGAAATTTCT
TTTTTAGAAAACACCCCCTTGTATGCCAGGCAGGTTTTAGTCAAAAATTTAGGCAATGGGAGTTCTAACATGATTGATGT
GAGTTTGGAGGGCTTGGGGCGTTATTTGAAAATCTTTAATTCAGATTCTAGCCATGTGAATAAAGTGAAAGCGTTGCAAA
AAGACTACCCTAAAGAATGGCGTGAAAAACTTTTGAAGAGTTAG

Domains

Predicted by InterproScan.

CagE, TrbE, VirB family, component of type IV transporter system (CagE_TrbE_VirB)

(176-375)

FtsK/SpoIIIE family (FtsK_SpoIIIE)

(430-466)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1A9HAD3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comB4 Helicobacter pylori 26695

94.917

100

0.949

Multiple sequence alignment