Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpC   Type   Regulator
Locus tag   MGAS23530_RS03330 Genome accession   NZ_CP013839
Coordinates   673329..675428 (-) Length   699 a.a.
NCBI ID   WP_031488351.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain MGAS23530     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 668329..680428
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MGAS23530_RS03305 (MGAS23530_0686) - 668806..669645 (+) 840 WP_011017679.1 thymidylate synthase -
  MGAS23530_RS03310 (MGAS23530_0687) - 669725..670222 (+) 498 WP_031488353.1 dihydrofolate reductase -
  MGAS23530_RS03315 (MGAS23530_0689) clpX 670542..671771 (+) 1230 WP_031488352.1 ATP-dependent Clp protease ATP-binding subunit ClpX Regulator
  MGAS23530_RS03320 (MGAS23530_0690) yihA 671781..672380 (+) 600 WP_002990160.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
  MGAS23530_RS03325 (MGAS23530_0691) - 672528..673271 (+) 744 WP_002984942.1 hypothetical protein -
  MGAS23530_RS03330 (MGAS23530_0692) clpC 673329..675428 (-) 2100 WP_031488351.1 AAA family ATPase Regulator
  MGAS23530_RS03335 (MGAS23530_0693) rpiA 675806..676489 (+) 684 WP_002984936.1 ribose-5-phosphate isomerase RpiA -
  MGAS23530_RS03340 (MGAS23530_0694) - 676566..677777 (+) 1212 WP_031488350.1 phosphopentomutase -
  MGAS23530_RS03345 (MGAS23530_0695) arsC 677796..678236 (+) 441 WP_023079098.1 arsenate reductase (glutaredoxin) -
  MGAS23530_RS03350 (MGAS23530_0696) - 678220..679029 (+) 810 WP_031488349.1 purine-nucleoside phosphorylase -
  MGAS23530_RS03355 (MGAS23530_0697) deoD 679692..680405 (+) 714 WP_002990147.1 purine-nucleoside phosphorylase -

Sequence

Protein


Download         Length: 699 a.a.        Molecular weight: 77244.34 Da        Isoelectric Point: 5.7799

>NTDB_id=142853 MGAS23530_RS03330 WP_031488351.1 673329..675428(-) (clpC) [Streptococcus pyogenes strain MGAS23530]
MTHFSGKDPFVNMDDIFNQLMANMGGYRSENPRYLVNGREITPEEFQHYRQTGQLPVATTKATNSQMLTPKADSVLTQLG
TNLTQEARQGHLDPVIGRNKEIQDTAEILARRTKNNPVLVGDAGVGKTAVIEGLAQAIVNGDVPAAIKNKEIVSIDISSL
EAGTQYRGSFEETIQNLIQEVKEAGNIILFFDEIHQIVGAGATSSDSGSKGLADILKPALSRGELTLIGATTQDEYRNTI
LKNAALARRFNEVKVNAPSAEDTFHILMGIRNLYEQHHHITLPDNVLKAAVDYSIQYIPQRSLPDKAIDLLDMTAAHLAA
QHPVTDLKTLETEIAKQKESQEKAVAKEDFEKALAAKTRIETLQKQIEQHNQSQNVTATVNDIAESVERLTGIPVSNMGT
NDLERLKGISSRLKSHVIGQDEAVAAVARAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLALDLFGSKDAIIRLD
MSEYNDRTAVSKLIGTTAGYVGYDDNNNTLTERVRRNPYAIVLLDEIEKADPQIITLLLQVLDDGRLTDGQGNTINFKNT
VIIATSNAGFGQQDTETSGSNIMDRIAPYFRPEFLNRFNSIIKFNHLQKENLEEIVDLMLAEVNQTTAKKGISLTIADDA
KAHLIDLGYNHAMGARPLRRIIEQEIRDRITDYYLDHPEVKKLQAILKEGQLVIKQKDQ

Nucleotide


Download         Length: 2100 bp        

>NTDB_id=142853 MGAS23530_RS03330 WP_031488351.1 673329..675428(-) (clpC) [Streptococcus pyogenes strain MGAS23530]
ATGACACATTTTTCTGGTAAAGATCCTTTTGTAAATATGGATGATATTTTCAACCAATTAATGGCAAACATGGGTGGTTA
TCGTAGCGAAAATCCCCGCTATCTCGTTAACGGTCGCGAAATAACTCCCGAAGAATTCCAACACTATCGTCAAACAGGAC
AACTCCCTGTAGCGACAACCAAAGCAACAAATTCTCAAATGTTAACACCTAAAGCTGATAGTGTATTGACTCAACTCGGA
ACTAACTTAACACAAGAAGCTCGTCAAGGGCATCTTGACCCCGTCATTGGTCGTAACAAAGAAATTCAAGATACCGCTGA
AATCTTGGCACGACGAACTAAAAATAATCCTGTCCTTGTCGGAGATGCTGGTGTCGGTAAAACTGCAGTCATTGAAGGTT
TAGCTCAAGCCATTGTTAATGGAGATGTCCCAGCTGCTATTAAAAACAAGGAAATCGTATCAATTGATATTTCTAGTCTT
GAAGCTGGTACACAGTATCGTGGTTCCTTTGAAGAGACCATTCAAAACTTGATTCAAGAAGTAAAAGAAGCTGGGAATAT
CATCTTATTTTTTGATGAAATTCATCAAATAGTTGGTGCTGGTGCCACAAGCAGTGATTCAGGCTCAAAGGGACTTGCAG
ATATTCTTAAACCAGCCTTGTCACGAGGAGAATTAACACTGATTGGTGCTACTACTCAAGACGAATACCGCAATACTATT
TTAAAAAATGCTGCTCTTGCTCGTCGCTTTAATGAAGTTAAAGTGAATGCACCATCAGCTGAAGATACTTTTCACATTTT
AATGGGTATTCGTAATCTTTATGAACAACACCACCATATTACCCTTCCTGATAATGTTCTAAAAGCTGCTGTTGATTATT
CTATTCAATACATCCCACAGCGTAGCCTGCCAGATAAAGCAATTGACTTACTGGATATGACAGCTGCTCATTTAGCTGCG
CAACACCCGGTCACTGACTTAAAAACACTCGAAACTGAAATAGCTAAACAAAAAGAGAGTCAAGAAAAAGCTGTCGCCAA
AGAAGACTTTGAAAAAGCTTTAGCAGCAAAAACACGGATTGAAACATTACAAAAGCAAATTGAGCAACATAACCAAAGCC
AAAATGTTACTGCTACAGTCAATGATATCGCAGAGTCTGTAGAGCGCTTAACTGGTATTCCCGTCTCTAACATGGGGACT
AATGATTTAGAAAGGCTCAAAGGAATTAGCAGCCGCTTAAAAAGCCATGTCATCGGACAAGATGAGGCTGTTGCAGCAGT
AGCACGTGCTATTCGACGAAATCGAGCAGGTTTTGATGATGGTAACCGTCCAATAGGTTCTTTCCTTTTTGTGGGTCCAA
CTGGTGTTGGTAAAACAGAGTTAGCTAAACAATTAGCACTTGATTTATTTGGTTCCAAAGATGCTATTATTCGACTTGAT
ATGTCCGAATATAACGATCGCACTGCTGTGTCAAAATTGATTGGGACAACGGCTGGTTATGTTGGCTACGATGATAATAA
TAATACCCTAACTGAGCGTGTTCGTCGTAACCCTTATGCTATTGTCTTACTAGATGAAATTGAAAAAGCTGATCCTCAAA
TCATTACACTTCTTCTACAAGTGTTAGATGATGGACGATTGACAGATGGACAAGGAAATACTATTAACTTTAAAAATACC
GTTATTATTGCTACATCAAATGCCGGTTTTGGCCAACAAGATACGGAAACTTCTGGGTCTAACATTATGGATCGCATTGC
ACCTTATTTCAGACCAGAGTTTTTGAACCGTTTTAATAGTATCATTAAATTTAATCATCTGCAAAAAGAAAATTTAGAAG
AAATTGTTGATTTAATGCTAGCTGAAGTAAATCAAACCACCGCAAAAAAAGGTATTAGTTTAACGATTGCTGATGACGCT
AAAGCTCATTTGATAGATTTAGGGTACAATCACGCTATGGGAGCTCGTCCATTACGACGTATTATCGAACAGGAAATTCG
TGACCGTATAACTGATTATTATCTTGACCATCCAGAAGTCAAAAAACTTCAGGCAATCCTAAAAGAAGGACAACTAGTGA
TTAAGCAAAAAGATCAGTAA

Domains

Predicted by InterProScan.

ATPase family associated with various cellular activities (AAA) (AAA)

(118-250)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(607-678)

AAA lid domain (AAA_lid_9)

(259-353)

AAA domain (Cdc48 subfamily) (AAA_2)

(443-600)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpC Lactococcus lactis subsp. cremoris KW2

47.084

100

0.474
  clpE Streptococcus mutans UA159

49.688

91.559

0.455
  clpE Streptococcus pneumoniae TIGR4

49.209

90.415

0.445
  clpE Streptococcus pneumoniae Rx1

49.209

90.415

0.445
  clpE Streptococcus pneumoniae D39

49.209

90.415

0.445
  clpE Streptococcus pneumoniae R6

49.209

90.415

0.445
  clpC Bacillus subtilis subsp. subtilis str. 168

44.812

95.136

0.426
  clpC Streptococcus thermophilus LMD-9

42.79

91.273

0.391
  clpC Streptococcus pneumoniae Rx1

41.871

93.276

0.391
  clpC Streptococcus pneumoniae D39

41.871

93.276

0.391
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

41.348

93.419

0.386
  clpC Streptococcus thermophilus LMG 18311

42.587

90.701

0.386
  clpC Streptococcus pneumoniae TIGR4

42.857

90.129

0.386
  clpC Streptococcus mutans UA159

41.562

91.559

0.381

Multiple sequence alignment