Detailed information NTG0138429

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: AKK22_RS07705
• Genome accession: NZ_CP013029
• Coordinates: 1404969..1407245 (+)
• Length: 758 a.a.
• NCBI ID: WP_032208047.1
• Uniprot ID: -
• Organism: Escherichia coli strain 2012C-4227
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 1399969..1412245

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AKK22_RS07660 (AKK22_07195)	-	1400068..1400406 (+)	339	WP_016241300.1	phage head closure protein	-
AKK22_RS07665 (AKK22_07200)	-	1400403..1400699 (+)	297	WP_000134111.1	head-tail connector protein	-
AKK22_RS07670 (AKK22_07205)	-	1400699..1401139 (+)	441	WP_001145908.1	HNH endonuclease signature motif containing protein	-
AKK22_RS32630 (AKK22_07210)	-	1401123..1401305 (+)	183	WP_024166058.1	hypothetical protein	-
AKK22_RS07680 (AKK22_07215)	-	1401428..1401784 (+)	357	WP_000113648.1	phage terminase small subunit P27 family	-
AKK22_RS07685 (AKK22_07220)	-	1401768..1403428 (+)	1661	Protein_1375	terminase large subunit	-
AKK22_RS07690 (AKK22_07225)	-	1403442..1403723 (+)	282	WP_032208053.1	hypothetical protein	-
AKK22_RS07700 (AKK22_07235)	clpS	1404618..1404938 (+)	321	WP_000520781.1	ATP-dependent Clp protease adapter ClpS	-
AKK22_RS07705 (AKK22_07240)	clpC	1404969..1407245 (+)	2277	WP_032208047.1	ATP-dependent Clp protease ATP-binding subunit ClpA	Regulator
AKK22_RS07715 (AKK22_07250)	infA	1407990..1408208 (-)	219	WP_001040187.1	translation initiation factor IF-1	-
AKK22_RS07720 (AKK22_07255)	aat	1408493..1409197 (-)	705	WP_032208045.1	leucyl/phenylalanyl-tRNA--protein transferase	-
AKK22_RS07725 (AKK22_07260)	cydC	1409239..1410960 (-)	1722	WP_001202188.1	heme ABC transporter ATP-binding protein/permease CydC	-

Sequence

Protein

• Length: 758 a.a.
• Molecular weight: 84192.90 Da
• Isoelectric Point: 6.2512

>NTDB_id=138429 AKK22_RS07705 WP_032208047.1 1404969..1407245(+) (clpC) [Escherichia coli strain 2012C-4227]
MLNQELELSLNMAFARAREHRHEFMTVEHLLLALLSNPSAREALEACSVDLVALRQELEAFIEQTTPVLPASEEERDTQP
TLSFQRVLQRAVFHVQSSGRNEVTGANVLVAIFSEQESQAAYLLRKHEVSRLDVVNFISHGTRKDEPTQSSDPGSQPNSE
EQAGGEERMENFTTNLNQLARVGGIDPLIGREKELERAIQVLCRRRKNNPLLVGESGVGKTAIAEGLAWRIVQGDVPEVM
ADCTIYSLDIGSLLAGTKYRGDFEKRFKALLKQLEQDTNSILFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKIRVIG
STAYQEFSNIFEKDRALARRFQKIDITEPSIEETVQIINGLKPKYEAHHDVRYTAKAVRAAVELAVKYINDRHLPDKAID
VIDEAGARARLMPVSKRKKTVNVADIESVVARIARIPEKSVSQSDRDTLKNLGDRLKMLVFGQDKAIEALTEAIKMARAG
LGHEHKPVGSFLFAGPTGVGKTEVTVQLSKALGIELLRFDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTDAVIKHPHAV
LLLDEIEKAHPDVFNILLQVMDNGTLTDNNGRKADFRNVVLVMTTNAGVRETERKSIGLIHQDNSTDAMEEIKKIFTPEF
RNRLDNIIWFDHLSTDVIHQVVDKFIVELQVQLDQKGVSLEVSQEARNWLAEKGYDRAMGARPMARVIQDNLKKPLANEL
LFGSLVDGGQVTVALDKEKNELTYGYQSAQKHKAEAAH

Nucleotide

• Length: 2277 bp

>NTDB_id=138429 AKK22_RS07705 WP_032208047.1 1404969..1407245(+) (clpC) [Escherichia coli strain 2012C-4227]
ATGCTCAATCAAGAACTGGAACTCAGTTTAAATATGGCTTTCGCCAGAGCGCGCGAGCACCGTCATGAGTTTATGACCGT
CGAGCACTTGTTACTGGCGCTGCTCAGTAACCCATCTGCCCGGGAGGCGCTGGAAGCGTGTTCTGTGGATTTGGTTGCGC
TCCGTCAGGAACTGGAAGCCTTTATTGAACAAACCACACCCGTTCTGCCTGCCAGTGAAGAGGAGCGCGACACACAGCCG
ACGCTGAGTTTTCAGCGTGTACTGCAACGTGCGGTCTTCCATGTTCAGTCCTCCGGTCGCAATGAGGTTACCGGTGCAAA
CGTTCTGGTCGCTATCTTTAGCGAACAGGAGTCGCAGGCGGCATATCTGTTGCGTAAACATGAAGTCAGCCGTCTCGATG
TGGTGAATTTTATCTCTCATGGCACGCGTAAAGACGAGCCGACACAGTCTTCTGATCCTGGCAGCCAGCCAAACAGCGAA
GAACAAGCTGGTGGGGAGGAACGTATGGAGAATTTCACGACGAACCTGAATCAGCTTGCGCGCGTGGGCGGAATCGACCC
ACTGATTGGTCGTGAGAAGGAGCTGGAGCGTGCTATTCAGGTTCTCTGCCGTCGCCGTAAAAACAACCCGCTGCTGGTGG
GGGAATCTGGTGTCGGTAAAACCGCGATTGCAGAAGGTCTTGCCTGGCGAATTGTTCAGGGCGATGTGCCGGAAGTGATG
GCTGACTGTACGATTTACTCTCTCGATATCGGTTCTCTGTTAGCGGGCACAAAATATCGCGGCGACTTTGAAAAACGTTT
TAAAGCGTTGCTCAAGCAGCTGGAGCAGGACACTAACAGCATCCTGTTTATTGATGAGATCCACACCATTATCGGTGCGG
GGGCAGCGTCTGGTGGTCAGGTCGATGCGGCTAACCTAATCAAACCGTTGCTCTCCAGCGGTAAAATTCGTGTAATTGGT
TCGACAGCCTATCAGGAGTTCAGCAACATTTTCGAGAAAGACCGTGCTCTGGCGCGTCGCTTCCAGAAAATTGATATTAC
TGAACCGTCAATCGAAGAAACTGTTCAAATCATCAATGGCCTGAAACCGAAGTATGAAGCGCACCACGACGTGCGTTATA
CCGCAAAAGCGGTGCGTGCGGCGGTAGAGCTGGCGGTGAAATACATCAATGATCGTCATCTGCCGGATAAAGCGATTGAT
GTTATCGACGAAGCGGGCGCTCGCGCACGCCTGATGCCGGTAAGCAAACGCAAGAAAACCGTTAATGTGGCGGATATTGA
GTCCGTGGTGGCCCGTATTGCACGCATTCCAGAGAAGAGTGTTTCTCAGAGTGACCGCGATACCCTGAAAAACCTCGGCG
ATCGCCTGAAAATGCTGGTCTTCGGTCAGGATAAAGCCATTGAGGCGCTGACTGAAGCCATTAAGATGGCGCGTGCAGGT
TTAGGTCACGAACATAAACCGGTCGGTTCGTTCCTGTTTGCCGGTCCTACCGGGGTCGGGAAAACAGAGGTGACGGTACA
GCTTTCGAAAGCTTTGGGCATTGAGCTTCTGCGCTTTGATATGTCCGAGTATATGGAACGCCATACCGTCAGCCGTCTGA
TTGGTGCGCCTCCGGGATACGTTGGTTTTGATCAGGGCGGTTTGCTGACTGATGCGGTCATCAAGCATCCACATGCGGTT
CTGCTGCTGGACGAAATCGAGAAAGCGCACCCTGACGTGTTCAATATTCTGTTGCAGGTGATGGACAACGGTACGCTGAC
CGATAACAACGGACGCAAAGCGGACTTCCGTAACGTGGTGCTGGTGATGACCACCAACGCCGGGGTACGTGAAACTGAGC
GTAAATCCATTGGTCTTATCCACCAGGATAACAGCACCGATGCGATGGAGGAGATCAAGAAGATCTTTACACCGGAATTC
CGTAACCGTCTCGACAACATTATCTGGTTTGATCATCTGTCAACCGACGTGATCCATCAGGTGGTGGATAAATTCATCGT
CGAGTTGCAGGTTCAGCTGGATCAGAAAGGTGTTTCTCTGGAAGTGAGCCAGGAAGCGCGTAACTGGCTGGCCGAGAAAG
GTTACGACCGGGCAATGGGCGCACGTCCGATGGCGCGTGTCATCCAGGACAACCTGAAAAAACCGCTCGCCAACGAACTG
CTGTTTGGTTCGCTGGTGGACGGCGGTCAGGTCACCGTCGCGCTGGATAAAGAGAAAAATGAGTTGACTTACGGATACCA
GAGTGCACAAAAGCACAAGGCGGAAGCAGCGCATTAA

Domains

Predicted by InterProScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (486-647)

• AAA lid domain (AAA_lid_9) (350-452)

• ATPase family associated with various cellular activities (AAA) (AAA) (211-327)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (13-62)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (653-733)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	38.742	100	0.406
clpA	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	41.209	96.042	0.396
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	35.337	100	0.38
clpC	Streptococcus thermophilus LMD-9	42.222	89.05	0.376
clpC	Streptococcus thermophilus LMG 18311	42.074	89.05	0.375
clpC	Streptococcus mutans UA159	39.266	93.404	0.367