Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   ACT74_RS02940 Genome accession   NZ_CP012958
Coordinates   607603..609432 (-) Length   609 a.a.
NCBI ID   WP_005567177.1    Uniprot ID   -
Organism   Aggregatibacter actinomycetemcomitans strain VT1169     
Function   homologous recombination (predicted from homology)   
Homologous recombination

Genomic Context

Location: 602603..614432
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACT74_RS02920 (ACT74_02920) - 603322..604391 (+) 1070 Protein_578 ABC transporter ATP-binding protein -
  ACT74_RS02925 (ACT74_02925) - 604388..605257 (+) 870 WP_005567173.1 ABC transporter permease -
  ACT74_RS02930 (ACT74_02930) - 605254..606105 (+) 852 WP_061869858.1 ABC transporter permease -
  ACT74_RS02935 (ACT74_02935) - 606125..607216 (+) 1092 WP_050846362.1 extracellular solute-binding protein -
  ACT74_RS02940 (ACT74_02940) uvrC 607603..609432 (-) 1830 WP_005567177.1 excinuclease ABC subunit UvrC Machinery gene
  ACT74_RS02945 (ACT74_02945) kdsB 609571..610344 (-) 774 WP_005570275.1 3-deoxy-manno-octulosonate cytidylyltransferase -
  ACT74_RS02950 (ACT74_02950) - 610346..610525 (-) 180 WP_005567179.1 Trm112 family protein -
  ACT74_RS02955 (ACT74_02955) lpxK 610547..611521 (-) 975 WP_005589925.1 tetraacyldisaccharide 4'-kinase -
  ACT74_RS02960 (ACT74_02960) msbA 611540..613288 (-) 1749 WP_061869859.1 lipid A ABC transporter ATP-binding protein/permease MsbA -

Sequence

Protein


Download         Length: 609 a.a.        Molecular weight: 69083.11 Da        Isoelectric Point: 9.5140

>NTDB_id=137670 ACT74_RS02940 WP_005567177.1 607603..609432(-) (uvrC) [Aggregatibacter actinomycetemcomitans strain VT1169]
MTFDAKKFLANVPHLPGVYRMYDDKSTVIYVGKAKDLKKRLSSYFRKQLSSKKTEALVASIQHIETTITTSETEALLLEH
NYIKTYQPRYNVLLRDDKSYPYILLTKETHPRITAYRGSKKIQGEYFGPYPNAGAVRETLSLLQKLFPIRQCENSVYNNR
SRPCLQYQIGRCLAPCVKGYVTDEAYAQQVNFARLFLQGKDQQVLDHLVKQMEQASQQLNFEEAARVRDQIQAVRAVIEK
QFVANDRHDDIDIIAITYQLGVACVQVLFIRQGKILGNRSYFPKVPSNTNLAELTETFVGQFYLQAHQGRTIPNTIIVDQ
KLDEKVDLETLLSDQAGRKVSIQDHAKGDKSKYLQLAQMNAKAALVTKLKQSTLQHDRYVALQELLGIAAIKRMECFDIS
HTMGEQTTASCVVFNQDGPLKSDYRRFNISGITKGDDYAAMEQALLKRYDKDLEDDKIPDIIFIDGGKGQLNRALQVFEN
LNVKWNKNQPHLIGVAKGVDRRAGLETLILSKWDKELHLPADSLALHLIQHIRDESHNHAISGHRKKRQQHFTQSGLESI
EGVGAKRRQALLKYLGGLQGVKNATLDEIASVPGISKALAEKIFETLQH

Nucleotide


Download         Length: 1830 bp        

>NTDB_id=137670 ACT74_RS02940 WP_005567177.1 607603..609432(-) (uvrC) [Aggregatibacter actinomycetemcomitans strain VT1169]
ATGACTTTCGACGCCAAAAAATTCCTCGCCAACGTACCGCACTTACCGGGCGTTTATCGTATGTATGACGATAAAAGCAC
GGTGATTTATGTGGGCAAGGCGAAAGATCTGAAAAAACGCTTATCCAGTTATTTTCGCAAGCAGTTAAGCAGCAAAAAAA
CGGAAGCATTGGTGGCGTCGATTCAGCATATCGAAACCACCATTACCACATCGGAAACCGAAGCCCTGCTCCTAGAGCAC
AATTACATCAAAACCTACCAGCCGCGCTATAACGTGCTGTTGCGCGATGATAAATCTTATCCGTACATTTTATTAACCAA
AGAAACCCACCCGCGTATTACCGCTTATCGCGGTTCGAAAAAAATCCAAGGGGAATATTTCGGTCCTTATCCGAATGCCG
GTGCAGTGCGCGAAACCCTGTCTTTATTACAAAAACTGTTCCCCATTCGGCAGTGTGAAAACTCCGTGTATAACAACCGT
TCGCGCCCCTGTTTGCAGTATCAAATCGGGCGTTGTCTGGCGCCTTGCGTAAAGGGCTATGTGACCGATGAAGCCTATGC
GCAGCAGGTCAATTTCGCCCGCTTGTTTTTACAAGGAAAAGATCAACAGGTGCTGGATCATTTGGTGAAGCAAATGGAAC
AGGCAAGTCAGCAACTGAATTTTGAAGAAGCGGCACGCGTTCGTGATCAAATTCAGGCAGTGCGGGCAGTAATTGAAAAA
CAATTTGTCGCCAACGATCGCCATGACGACATTGATATTATCGCCATCACCTATCAACTCGGCGTGGCCTGCGTGCAGGT
TTTGTTTATTCGTCAAGGTAAGATTTTGGGCAATCGCAGCTATTTTCCTAAAGTCCCGAGCAATACCAATCTGGCAGAAC
TCACGGAAACCTTTGTGGGGCAATTTTATTTGCAGGCGCACCAAGGCAGAACCATTCCGAACACCATTATCGTGGATCAA
AAACTGGACGAAAAAGTCGATTTGGAAACTTTACTCAGCGACCAAGCGGGACGCAAAGTCAGCATTCAGGATCATGCCAA
AGGCGATAAAAGCAAATATTTGCAACTGGCACAAATGAACGCCAAAGCGGCGTTAGTCACCAAATTAAAACAATCCACAT
TACAGCACGATCGCTACGTCGCACTGCAGGAATTACTCGGCATCGCTGCCATCAAACGCATGGAATGTTTCGACATCAGC
CACACCATGGGCGAACAAACCACCGCCTCCTGCGTGGTTTTCAACCAAGACGGACCGCTGAAATCCGATTACCGCCGTTT
CAACATCAGCGGCATCACCAAAGGCGACGATTACGCCGCCATGGAACAAGCCCTGTTAAAACGCTACGACAAAGATCTGG
AAGACGACAAAATTCCCGACATTATTTTTATCGACGGCGGCAAGGGACAACTCAACCGCGCGTTGCAGGTGTTCGAAAAC
CTTAATGTAAAATGGAACAAAAACCAACCGCACTTAATCGGTGTTGCCAAAGGCGTGGATCGTCGTGCCGGTTTGGAAAC
CTTGATTTTGAGCAAATGGGACAAAGAATTGCATTTACCGGCGGACAGCCTTGCGCTTCACTTGATCCAGCATATCCGCG
ACGAAAGCCACAATCACGCCATTAGCGGACACCGCAAAAAACGCCAACAACATTTCACCCAAAGTGGCTTGGAAAGCATT
GAAGGCGTCGGCGCCAAACGCCGCCAAGCCCTGCTCAAATACCTCGGCGGCTTGCAAGGCGTCAAAAATGCCACCCTCGA
CGAAATCGCCTCCGTCCCCGGCATATCAAAAGCCCTGGCAGAAAAGATTTTTGAGACCTTGCAGCATTAG

Domains

Predicted by InterProScan.

GIY-YIG catalytic domain (GIY-YIG)

(16-91)

UvrB/uvrC motif (UVR)

(203-236)

Helix-hairpin-helix domain (HHH_5)

(557-608)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(384-541)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Streptococcus pneumoniae TIGR4

37.52

100

0.378
  uvrC Streptococcus pneumoniae R6

37.194

100

0.374
  uvrC Streptococcus pneumoniae D39

37.194

100

0.374

Multiple sequence alignment