Detailed information NTG0134429

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: A6701_RS12775
• Genome accession: NZ_CP012583
• Coordinates: 2668113..2670389 (+)
• Length: 758 a.a.
• NCBI ID: WP_003090432.1
• Uniprot ID: A0A0H2ZAW8
• Organism: Pseudomonas aeruginosa strain PA_D22
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 2663113..2675389

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A6701_RS12755 (A6701_12755)	-	2663306..2665531 (-)	2226	WP_003090437.1	NADP-dependent isocitrate dehydrogenase	-
A6701_RS12760 (A6701_12760)	icd	2665890..2667146 (+)	1257	WP_003090436.1	NADP-dependent isocitrate dehydrogenase	-
A6701_RS12765 (A6701_12765)	cspD	2667219..2667491 (-)	273	WP_003090435.1	cold shock domain-containing protein CspD	-
A6701_RS12770 (A6701_12770)	clpS	2667717..2668085 (+)	369	WP_003097649.1	ATP-dependent Clp protease adapter ClpS	-
A6701_RS12775 (A6701_12775)	clpC	2668113..2670389 (+)	2277	WP_003090432.1	ATP-dependent Clp protease ATP-binding subunit ClpA	Regulator
A6701_RS12780 (A6701_12780)	infA	2670471..2670689 (-)	219	WP_002553999.1	translation initiation factor IF-1	-
A6701_RS12785 (A6701_12785)	-	2670794..2671501 (-)	708	WP_003097644.1	arginyltransferase	-
A6701_RS12790 (A6701_12790)	aat	2671556..2672236 (-)	681	WP_003108768.1	leucyl/phenylalanyl-tRNA--protein transferase	-
A6701_RS12795 (A6701_12795)	trxB	2672274..2673224 (-)	951	WP_003090421.1	thioredoxin-disulfide reductase	-

Sequence

Protein

• Length: 758 a.a.
• Molecular weight: 84010.68 Da
• Isoelectric Point: 5.8904

>NTDB_id=134429 A6701_RS12775 WP_003090432.1 2668113..2670389(+) (clpC) [Pseudomonas aeruginosa strain PA_D22]
MLNRELEVTLNLAFKEARAKRHEFMTVEHLLLALLDNEAAATVLRACGANLDKLRRDLQEFIDSTTPLIPQHDDERETQP
TLGFQRVLQRAVFHVQSSGKREVTGANVLVAIFSEQESQAVFLLKQQSIARIDVVNYIAHGISKVPGHAEHPQDGEQDMQ
DEEGGESATSNHPLDAYASNLNELARQGRIDPLVGREHEVERVAQILARRRKNNPLLVGEAGVGKTAIAEGLAKRIVDGQ
VPDLLADSVVYSLDLGALLAGTKYRGDFEKRFKALLNELRKRPHAVLFIDEIHTIIGAGAASGGVMDASNLLKPVLSSGE
IRCIGSTTFQEFRGIFEKDRALARRFQKVDVTEPSVEDTYGILKGLKGRFEQHHHIEYSDEALRAAAELAARYINDRHMP
DKAIDVIDEAGAYQRLQPEEKRVKRIEVAQVEDIVAKIARIPPKHVTTSDKELLRNLERDLKLTVFGQDDAIESLSTAIK
LSRAGLKAPDKPVGSFLFAGPTGVGKTEVARQLAKALGVELVRFDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTEAITK
TPHCVLLLDEIEKAHPEVFNLLLQVMDHGTLTDNNGRKADFRNIILIMTTNAGAEVAARASIGFNQQDHTTDAMEVIKKS
FTPEFRNRLDTIIQFGRLSTETIKSVVDKFLTELQAQLEDKRVQLEVSDAARGWLAEKGYDVQMGARPMARLIQDKIKRP
LAEEILFGELAEHGGLVHVDLKGDELAFEFEITAAEPA

Nucleotide

• Length: 2277 bp

>NTDB_id=134429 A6701_RS12775 WP_003090432.1 2668113..2670389(+) (clpC) [Pseudomonas aeruginosa strain PA_D22]
ATGTTGAATCGAGAGCTCGAAGTCACCCTCAATCTCGCCTTCAAGGAGGCGAGGGCCAAACGCCATGAATTCATGACGGT
TGAGCACCTGCTGCTGGCCTTGCTGGACAATGAGGCGGCGGCAACGGTATTGCGTGCGTGCGGTGCCAACCTGGACAAGC
TGCGGCGCGACCTGCAGGAATTCATCGATTCCACCACGCCGCTGATCCCGCAGCACGACGACGAGCGCGAAACCCAGCCG
ACGCTGGGCTTCCAGCGCGTCCTGCAGCGTGCGGTGTTCCACGTGCAGAGTTCCGGCAAGCGCGAAGTGACCGGGGCCAA
TGTCCTGGTGGCGATCTTCAGCGAACAGGAAAGCCAGGCGGTGTTCCTGCTCAAGCAGCAGAGCATCGCGCGTATCGATG
TGGTGAACTACATCGCCCACGGCATCTCCAAGGTGCCCGGGCATGCCGAACATCCGCAGGATGGGGAGCAGGATATGCAG
GATGAGGAAGGTGGCGAGTCGGCCACGTCCAACCATCCGCTGGACGCCTATGCCAGCAACCTCAACGAACTGGCTCGCCA
GGGGCGGATCGACCCGCTGGTGGGGCGCGAGCATGAAGTCGAGCGGGTGGCGCAGATCCTTGCCCGCCGGCGCAAGAACA
ACCCGCTGCTGGTAGGCGAGGCGGGGGTCGGCAAGACGGCCATCGCCGAGGGCCTGGCCAAGCGCATCGTCGATGGCCAG
GTGCCGGACCTGCTGGCCGACAGCGTGGTCTACTCCCTCGACCTGGGTGCCTTGCTCGCGGGTACCAAGTACCGCGGCGA
CTTCGAGAAGCGCTTCAAGGCATTGCTCAACGAGTTGCGCAAGCGCCCGCACGCGGTGCTGTTCATCGACGAGATCCATA
CCATCATCGGCGCCGGTGCGGCATCCGGCGGGGTAATGGACGCCTCCAACCTGCTCAAGCCGGTCCTGTCCTCGGGCGAG
ATCCGCTGCATCGGCTCGACCACCTTCCAGGAGTTCCGCGGCATCTTCGAGAAGGACCGGGCCTTGGCGCGGCGCTTCCA
GAAGGTCGACGTGACCGAGCCGTCGGTGGAAGACACCTATGGCATCCTCAAGGGCCTCAAGGGGCGCTTCGAGCAGCATC
ACCACATCGAGTACAGCGACGAGGCGCTGCGCGCCGCGGCCGAGCTGGCGGCGCGCTACATCAACGACCGGCACATGCCG
GACAAGGCCATCGACGTCATCGACGAGGCGGGCGCCTACCAGCGCCTGCAGCCGGAAGAGAAGCGCGTGAAGCGCATCGA
GGTGGCGCAGGTCGAGGATATCGTGGCGAAGATCGCGCGGATCCCGCCGAAACACGTCACCACCTCCGACAAGGAGTTGC
TGCGCAACCTCGAACGCGACCTCAAGCTGACCGTGTTCGGCCAGGACGACGCCATCGAGTCGCTGTCCACCGCGATCAAG
CTGTCCCGGGCCGGGCTCAAGGCGCCGGACAAGCCGGTCGGCTCGTTCCTCTTCGCCGGTCCCACCGGCGTGGGCAAGAC
CGAGGTGGCGCGGCAGTTGGCGAAGGCCTTGGGCGTGGAGCTGGTGCGCTTCGACATGTCCGAGTACATGGAGCGGCATA
CCGTGTCGCGGCTGATCGGTGCGCCTCCGGGCTACGTCGGCTTCGACCAGGGCGGCCTGCTCACCGAGGCGATCACCAAG
ACCCCGCACTGCGTGTTGCTGCTCGACGAGATCGAGAAGGCTCACCCGGAGGTCTTCAACCTGCTGCTGCAGGTGATGGA
CCACGGCACCCTGACCGACAACAACGGGCGCAAGGCGGACTTCCGCAACATCATCCTGATCATGACCACCAACGCCGGCG
CGGAAGTGGCGGCGCGCGCGTCGATCGGCTTCAACCAGCAGGATCACACCACCGATGCGATGGAAGTGATCAAGAAGAGC
TTCACCCCGGAGTTCCGCAACCGCCTGGATACCATCATCCAGTTCGGCCGCCTGAGCACCGAGACGATCAAGAGCGTGGT
CGACAAGTTCCTCACCGAGCTGCAGGCGCAGCTGGAGGACAAGCGCGTCCAGCTCGAGGTCAGCGATGCGGCGCGCGGCT
GGCTGGCGGAGAAGGGCTACGACGTGCAGATGGGTGCGCGACCGATGGCGCGGCTTATCCAGGACAAGATCAAGCGGCCG
TTGGCCGAGGAGATCCTGTTCGGCGAGCTGGCCGAGCATGGCGGCCTGGTGCATGTCGACCTGAAGGGCGACGAGCTGGC
CTTCGAGTTCGAGATCACGGCGGCGGAGCCCGCCTGA

Domains

Predicted by InterProScan.

• ATPase family associated with various cellular activities (AAA) (AAA) (216-328)

• AAA lid domain (AAA_lid_9) (355-458)

• AAA domain (Cdc48 subfamily) (AAA_2) (491-652)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (13-62)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (658-739)

3D structure

• AlphaFold DB: A0A0H2ZAW8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	38.956	100	0.423
clpA	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	41.667	96.57	0.402
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	37.247	100	0.389
clpC	Streptococcus mutans UA159	45.484	81.794	0.372
clpC	Lactococcus lactis subsp. cremoris KW2	44.586	82.85	0.369