Detailed information NTG0131811

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: BWEI_RS26355
• Genome accession: NZ_CP009746
• Coordinates: 5349193..5351628 (+)
• Length: 811 a.a.
• NCBI ID: WP_002009819.1
• Uniprot ID: R8GYK4
• Organism: Bacillus mycoides strain WSBC10204
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 5344193..5356628

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BWEI_RS26305 (bwei_5575)	-	5344848..5345993 (-)	1146	WP_002029354.1	glycerate kinase	-
BWEI_RS26340 (bwei_5582)	ctsR	5346922..5347383 (+)	462	WP_002029353.1	transcriptional regulator CtsR	-
BWEI_RS26345 (bwei_5583)	-	5347553..5348101 (+)	549	WP_002009823.1	UvrB/UvrC motif-containing protein	-
BWEI_RS26350 (bwei_5584)	-	5348106..5349170 (+)	1065	WP_002124680.1	protein arginine kinase	-
BWEI_RS26355 (bwei_5585)	clpC	5349193..5351628 (+)	2436	WP_002009819.1	ATP-dependent protease ATP-binding subunit ClpC	Regulator
BWEI_RS26360 (bwei_5586)	radA	5351723..5353099 (+)	1377	WP_002009817.1	DNA repair protein RadA	Machinery gene
BWEI_RS26365 (bwei_5587)	disA	5353103..5354176 (+)	1074	WP_000392162.1	DNA integrity scanning diadenylate cyclase DisA	-
BWEI_RS26370 (bwei_5588)	-	5354337..5355440 (+)	1104	WP_002063406.1	PIN/TRAM domain-containing protein	-
BWEI_RS26375 (bwei_5589)	ispD	5355457..5356137 (+)	681	WP_002009811.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-

Sequence

Protein

• Length: 811 a.a.
• Molecular weight: 90627.54 Da
• Isoelectric Point: 6.4872

>NTDB_id=131811 BWEI_RS26355 WP_002009819.1 5349193..5351628(+) (clpC) [Bacillus mycoides strain WSBC10204]
MMFGRFTERAQKVLALSQEEAIRIGHNNIGTEHILLGLVREGEGIAAKALIALGLSPEKVQKEVEALIGRGTEASQTVHY
TPRAKKVIELSMDEARKLGHSYVGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNEASSGHQGGSSTNAN
TPTLDSLARDLTVVARENRLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIVNNEVPETLRDKRV
MTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIILFIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDE
YRKYIEKDAALERRFQPIHVDEPNLEESVQILKGLRDRYEAHHRVSITDDAIDAAVKLSDRYITDRFLPDKAIDLIDEAA
SKVRLRSYTTPPNLKELEVKLEEIRKEKDAAVQSQEFEKAASLRDMEQRLREKLEDTKRQWKEKQGQENSEVTVEDIANV
VSTWTRIPVSKLAQTETDKLLNLESILHDRLIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALA
ESMFGDEDAMIRIDMSEYMEKHSTSRLVGSPPGYVGYEEGGQLTEKVRRKPYSVVLLDEVEKAHPDVFNILLQVLEDGRL
TDSKGRTVDFRNTIVIMTSNVGADALKRNKHLGFNVQDESRDYSDMKGKVMDELKKAFRPEFLNRIDEIIVFHMLEKKHI
QEIVTLMVNQLVKRLKEQEIELHLTEGAISAIADKGFDREYGARPLRRAIQKHVEDRLSEELLKGAIEKGQKVIFDIEGE
SFVIHSAEKVK

Nucleotide

• Length: 2436 bp

>NTDB_id=131811 BWEI_RS26355 WP_002009819.1 5349193..5351628(+) (clpC) [Bacillus mycoides strain WSBC10204]
ATGATGTTTGGAAGATTTACAGAACGAGCACAGAAAGTATTAGCTTTATCTCAAGAGGAAGCAATTCGCATTGGGCATAA
TAATATTGGAACAGAACATATTTTACTTGGGCTTGTACGCGAAGGTGAAGGAATTGCAGCAAAAGCGTTAATTGCTCTTG
GATTAAGTCCAGAGAAAGTTCAAAAAGAGGTAGAAGCATTAATTGGACGTGGAACGGAAGCTTCTCAAACAGTACATTAC
ACACCTCGTGCTAAAAAAGTTATTGAGTTGTCTATGGACGAAGCTCGTAAGCTAGGCCATTCCTACGTTGGAACAGAACA
TATTTTACTTGGTTTAATCCGTGAAGGTGAAGGTGTAGCAGCACGCGTTTTAAATAATTTAGGTGTAAGCCTAAATAAAG
CAAGACAACAAGTGTTACAACTCCTTGGAAGTAATGAAGCTAGTTCAGGTCACCAGGGTGGTTCATCAACAAATGCGAAT
ACACCTACACTTGACAGTCTAGCACGTGATTTAACAGTTGTTGCACGTGAAAATCGTTTAGATCCTGTTATTGGACGTAG
TAAAGAAATTCAACGTGTAATTGAAGTGTTAAGCCGTAGAACAAAAAACAATCCAGTATTAATTGGAGAACCTGGTGTAG
GTAAGACAGCAATTGCGGAAGGATTAGCACAGCAAATTGTAAATAATGAAGTTCCTGAAACTTTAAGAGATAAGCGTGTT
ATGACATTAGATATGGGTACAGTTGTTGCTGGAACAAAATATCGTGGTGAATTTGAGGATCGTTTAAAGAAAGTGATGGA
TGAGATTCGCCAAGCTGGTAACATCATTCTATTTATTGATGAGCTTCATACGTTAATTGGTGCAGGCGGGGCGGAAGGTG
CAATTGATGCATCGAATATTTTAAAACCATCTTTAGCACGTGGTGAATTACAATGTATTGGTGCAACAACTTTAGACGAA
TATCGTAAATATATTGAAAAGGATGCGGCATTAGAAAGACGTTTCCAACCAATTCATGTTGATGAACCAAACTTAGAAGA
ATCAGTTCAAATTTTAAAAGGTTTACGTGACCGTTATGAGGCGCATCACCGCGTATCTATTACAGATGATGCAATCGATG
CGGCTGTAAAACTTTCAGATCGTTACATTACAGACCGTTTTTTACCTGATAAAGCAATCGATTTAATTGATGAGGCTGCA
TCAAAAGTGCGCTTACGTTCTTATACAACACCGCCAAACTTAAAAGAGCTTGAAGTGAAGCTTGAGGAAATTAGAAAAGA
AAAAGATGCAGCTGTACAAAGCCAAGAATTTGAAAAAGCTGCTTCTTTACGTGATATGGAACAACGTTTACGTGAAAAGT
TAGAAGATACAAAGCGTCAGTGGAAAGAGAAACAAGGACAAGAAAACTCAGAAGTAACAGTAGAAGATATTGCAAATGTC
GTTTCCACATGGACACGTATTCCAGTTTCTAAACTTGCACAAACAGAGACAGATAAATTATTAAACTTGGAATCAATTTT
ACATGATCGTTTAATTGGGCAGGATGAAGCAGTTGTAGCTGTGGCAAAAGCTGTTCGTCGTGCGAGAGCGGGATTAAAAG
ATCCGAAACGTCCAATTGGCTCATTTATTTTCCTAGGACCTACTGGTGTAGGTAAAACAGAACTAGCAAGGGCATTAGCA
GAATCTATGTTCGGTGATGAGGATGCAATGATCCGCATCGATATGTCTGAGTACATGGAAAAGCATTCTACTTCTCGTTT
AGTTGGATCTCCTCCAGGATATGTTGGATATGAAGAAGGTGGACAATTAACAGAGAAAGTTCGTCGTAAGCCATATTCAG
TTGTCTTATTAGATGAAGTAGAGAAAGCTCATCCTGATGTGTTTAATATTTTACTACAAGTATTAGAAGATGGCCGTTTA
ACAGATTCTAAAGGACGTACAGTTGATTTCCGTAATACAATTGTTATTATGACGTCTAATGTTGGTGCAGACGCATTAAA
ACGTAATAAACATCTTGGATTTAACGTACAAGATGAGAGCCGTGATTATTCAGATATGAAAGGTAAAGTAATGGATGAAT
TGAAAAAAGCATTTCGTCCAGAATTCTTAAACCGTATTGATGAAATTATCGTGTTCCATATGCTTGAGAAAAAACATATT
CAAGAAATTGTAACTCTTATGGTGAATCAGTTAGTGAAACGCTTAAAAGAACAAGAGATTGAATTGCACTTAACAGAAGG
AGCAATTTCAGCAATTGCTGATAAAGGATTTGATCGAGAGTACGGTGCTCGTCCGCTTCGTAGAGCAATTCAAAAACATG
TAGAAGATAGACTATCAGAAGAACTGTTAAAAGGTGCTATTGAGAAAGGACAAAAAGTTATCTTTGATATAGAAGGAGAA
TCATTTGTCATTCATAGTGCGGAAAAGGTAAAATAA

Domains

Predicted by InterproScan.

• ATPase family associated with various cellular activities (AAA) (AAA) (206-318)

• AAA lid domain (AAA_lid_9) (345-446)

• AAA domain (Cdc48 subfamily) (AAA_2) (537-709)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (715-793)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (18-69)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (93-143)

3D structure

• AlphaFold DB: R8GYK4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	85.926	99.877	0.858
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	50.25	98.644	0.496
clpC	Streptococcus thermophilus LMD-9	45.728	100	0.469
clpC	Streptococcus mutans UA159	44.762	100	0.464
clpC	Streptococcus thermophilus LMG 18311	45.235	100	0.462
clpC	Streptococcus pneumoniae D39	46.424	98.274	0.456
clpC	Streptococcus pneumoniae Rx1	46.424	98.274	0.456
clpC	Streptococcus pneumoniae TIGR4	46.125	98.644	0.455
clpE	Streptococcus mutans UA159	53.231	80.148	0.427
clpE	Streptococcus pneumoniae R6	52.241	79.778	0.417
clpE	Streptococcus pneumoniae TIGR4	52.241	79.778	0.417
clpE	Streptococcus pneumoniae Rx1	52.241	79.778	0.417
clpE	Streptococcus pneumoniae D39	52.241	79.778	0.417
clpC	Lactococcus lactis subsp. cremoris KW2	51.42	78.175	0.402