Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrB   Type   Machinery gene
Locus tag   SAGV69_RS00435 Genome accession   NZ_CP009681
Coordinates   88407..90035 (-) Length   542 a.a.
NCBI ID   WP_001186596.1    Uniprot ID   -
Organism   Staphylococcus aureus strain Gv69     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 40887..91402 88407..90035 within 0


Gene organization within MGE regions


Location: 40887..91402
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SAGV69_RS00165 (SAGV69_00035) - 40887..42566 (+) 1680 WP_016187646.1 recombinase family protein -
  SAGV69_RS00170 (SAGV69_00036) - 42655..42993 (+) 339 WP_000175892.1 SAUGI family uracil-DNA glycosylase inhibitor -
  SAGV69_RS00175 (SAGV69_00038) - 43087..43398 (+) 312 WP_001166716.1 DUF960 family protein -
  SAGV69_RS00180 (SAGV69_00039) - 43414..43920 (+) 507 WP_000848380.1 DUF1643 domain-containing protein -
  SAGV69_RS00185 (SAGV69_00040) - 43941..44258 (+) 318 WP_000659046.1 JAB domain-containing protein -
  SAGV69_RS00190 (SAGV69_00041) - 44377..45462 (+) 1086 WP_000868132.1 tyrosine-type recombinase/integrase -
  SAGV69_RS17300 (SAGV69_04176) - 45459..47355 (+) 1897 Protein_36 site-specific integrase -
  SAGV69_RS00205 - 47362..47740 (+) 379 Protein_37 DUF6262 family protein -
  SAGV69_RS16855 (SAGV69_04191) ant(9) 47891..48673 (+) 783 Protein_38 aminoglycoside nucleotidyltransferase ANT(9) -
  SAGV69_RS00215 erm(A) 48799..49530 (-) 732 WP_001072201.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) -
  SAGV69_RS00220 (SAGV69_00785) - 50064..50726 (+) 663 WP_001092058.1 class I SAM-dependent methyltransferase -
  SAGV69_RS17305 - 50958..51104 (+) 147 Protein_41 JAB domain-containing protein -
  SAGV69_RS00225 (SAGV69_00052) - 51274..52146 (+) 873 WP_000373151.1 HTH domain-containing protein -
  SAGV69_RS00230 (SAGV69_00053) - 52203..52493 (+) 291 WP_000065262.1 hypothetical protein -
  SAGV69_RS00235 (SAGV69_00054) - 52509..52997 (+) 489 WP_000397419.1 hypothetical protein -
  SAGV69_RS00245 (SAGV69_04177) - 53130..54302 (-) 1173 Protein_45 IS256-like element IS256 family transposase -
  SAGV69_RS00250 (SAGV69_00057) - 54464..54991 (+) 528 WP_000717928.1 hypothetical protein -
  SAGV69_RS00255 (SAGV69_00058) - 55053..55469 (+) 417 WP_000941331.1 hypothetical protein -
  SAGV69_RS17190 - 55758..55922 (+) 165 WP_001803222.1 hypothetical protein -
  SAGV69_RS00260 (SAGV69_00060) - 55936..56157 (+) 222 WP_001070883.1 hypothetical protein -
  SAGV69_RS00265 (SAGV69_00061) - 56293..56871 (+) 579 WP_020444591.1 PepSY domain-containing protein -
  SAGV69_RS00270 (SAGV69_00062) - 56951..59164 (-) 2214 Protein_51 type I restriction endonuclease subunit R -
  SAGV69_RS00280 (SAGV69_03258) - 60184..61530 (+) 1347 WP_000163428.1 NAD(P)/FAD-dependent oxidoreductase -
  SAGV69_RS00285 (SAGV69_03257) merR 61830..62237 (+) 408 WP_000425271.1 Hg(II)-responsive transcriptional regulator MerR -
  SAGV69_RS17480 - 62254..62608 (+) 355 Protein_55 TlpA disulfide reductase family protein -
  SAGV69_RS00295 (SAGV69_00067) - 62605..63285 (+) 681 WP_000010351.1 cytochrome c biogenesis protein CcdA -
  SAGV69_RS00300 (SAGV69_00068) - 63420..63758 (+) 339 WP_000968575.1 hypothetical protein -
  SAGV69_RS00305 (SAGV69_00069) merA 63816..65459 (+) 1644 WP_000193219.1 mercury(II) reductase -
  SAGV69_RS00310 (SAGV69_04175) merB 65541..66190 (+) 650 Protein_59 organomercurial lyase MerB -
  SAGV69_RS00315 (SAGV69_00070) - 66385..66915 (-) 531 WP_041205518.1 hypothetical protein -
  SAGV69_RS00320 (SAGV69_00071) - 66951..67625 (-) 675 WP_001106057.1 IS6-like element IS257 family transposase -
  SAGV69_RS15955 - 67709..68050 (+) 342 WP_001797647.1 hydroxymethylglutaryl-CoA synthase -
  SAGV69_RS00330 (SAGV69_00073) - 68927..69670 (+) 744 WP_000958858.1 glycerophosphoryl diester phosphodiesterase -
  SAGV69_RS00335 (SAGV69_00074) - 69767..70195 (+) 429 WP_000872606.1 MaoC family dehydratase -
  SAGV69_RS00340 (SAGV69_00075) mecA 70241..72250 (-) 2010 WP_078056052.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  SAGV69_RS00345 (SAGV69_00076) mecR1 72347..74104 (+) 1758 WP_000952923.1 beta-lactam sensor/signal transducer MecR1 -
  SAGV69_RS00350 mecI 74104..74475 (+) 372 Protein_67 mecA-type methicillin resistance repressor MecI -
  SAGV69_RS16870 (SAGV69_00078) psm-mec 74560..74628 (-) 69 WP_014532405.1 phenol-soluble modulin PSM-mec -
  SAGV69_RS00355 (SAGV69_00079) - 74948..76096 (+) 1149 WP_000427807.1 ROK family transcriptional regulator -
  SAGV69_RS00365 (SAGV69_00081) cstB 76211..77545 (-) 1335 Protein_70 persulfide dioxygenase-sulfurtransferase CstB -
  SAGV69_RS00370 (SAGV69_00082) - 77576..78640 (-) 1065 WP_000438836.1 DsrE/DsrF/DrsH-like family protein -
  SAGV69_RS00375 cstR 78776..79036 (+) 261 WP_000220507.1 persulfide-sensing transcriptional repressor CstR -
  SAGV69_RS00380 (SAGV69_00084) - 79036..79674 (+) 639 Protein_73 sulfite exporter TauE/SafE family protein -
  SAGV69_RS00385 (SAGV69_00085) - 79948..80565 (-) 618 WP_000562107.1 CadD family cadmium resistance transporter -
  SAGV69_RS00390 (SAGV69_00086) - 80646..83060 (-) 2415 WP_000378485.1 cadmium-translocating P-type ATPase CadA -
  SAGV69_RS00395 (SAGV69_00087) - 83053..83418 (-) 366 WP_000159127.1 metalloregulator ArsR/SmtB family transcription factor -
  SAGV69_RS00400 (SAGV69_00088) - 83656..84033 (-) 378 WP_000361060.1 DUF6262 family protein -
  SAGV69_RS00405 (SAGV69_00089) - 84040..85932 (-) 1893 WP_020444597.1 site-specific integrase -
  SAGV69_RS00410 (SAGV69_00091) - 86127..86450 (-) 324 WP_000088091.1 JAB domain-containing protein -
  SAGV69_RS00415 - 86443..86648 (-) 206 Protein_80 hypothetical protein -
  SAGV69_RS00420 (SAGV69_00093) - 86650..87171 (-) 522 WP_000836008.1 DUF1643 domain-containing protein -
  SAGV69_RS00425 (SAGV69_00094) - 87190..87501 (-) 312 WP_000833212.1 DUF960 family protein -
  SAGV69_RS00430 - 87586..87936 (-) 351 WP_000171449.1 SAUGI family uracil-DNA glycosylase inhibitor -
  SAGV69_RS00435 (SAGV69_00096) ccrB 88407..90035 (-) 1629 WP_001186596.1 recombinase family protein Machinery gene
  SAGV69_RS00440 (SAGV69_00097) ccrA 90056..91402 (-) 1347 WP_000816499.1 recombinase family protein Machinery gene

Sequence

Protein


Download         Length: 542 a.a.        Molecular weight: 62274.15 Da        Isoelectric Point: 9.7334

>NTDB_id=131116 SAGV69_RS00435 WP_001186596.1 88407..90035(-) (ccrB) [Staphylococcus aureus strain Gv69]
MQQLKQKRVGIYVRVSTEIQSTEGYSIDGQINQIREYCDFNNFVVVDVYADRGISGKSMNRPELQRLLKDANEGQIDSVM
VYKTNRLARNTSDLLKIVEDLHRQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSIGSVTYILSNPFYVGKIQFAK
YKDWNEKRRKGLNDKPIIAEGKHSPIIIQDLWDKVQLRKKQVSQKPQVHGKGTNLLTGIVHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEKYVMDQILEIVKSDKVINQVLERVNQENKVDIGALNHDIAYKQQQYD
EVSGKLHNLVKTIEDNPDLTSALKATIHQYETQLNDITNQMNQLKQQQNQEKLSYDTKQIAALLQRIFQNIESMDKAQLK
ALYLTVIDRIDIRKDGNHKKQFYVTLKLNNEIIKQLFNNTPLDEVLLSTSSLFLPQTLFLQI

Nucleotide


Download         Length: 1629 bp        

>NTDB_id=131116 SAGV69_RS00435 WP_001186596.1 88407..90035(-) (ccrB) [Staphylococcus aureus strain Gv69]
ATGCAACAACTCAAACAAAAACGTGTCGGTATCTATGTTCGTGTATCAACGGAAATCCAAAGTACTGAAGGCTATAGTAT
CGATGGACAAATCAATCAAATTCGAGAATATTGTGATTTCAATAACTTTGTTGTTGTAGATGTATACGCGGATAGAGGTA
TCTCTGGAAAATCTATGAACCGACCAGAACTACAACGTTTGTTAAAAGATGCGAACGAAGGTCAGATTGATTCTGTTATG
GTCTACAAAACAAACCGACTAGCACGTAACACTTCTGACTTACTCAAAATTGTTGAAGACCTTCATCGTCAAAATGTCGA
ATTCTTCAGCTTATCTGAGCGTATGGAAGTCAATACAAGCAGTGGTAAATTGATGCTACAAATTCTAGCGAGTTTTTCAG
AATTTGAAAGAAATAATATTGTCGAAAATGTATTCATGGGTCAAACCCGACGCGCTCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCGGATAGCAAGCATGAACTCATGATAAACCAACATGAAGCGAATATTGTCAAATA
TATATTTGAGTCATATGCTAAAGGCCACGGATATCGTAAAATTGCGAATGCACTCAATCACAAAGGATACGTGACTAAAA
AAGGAAAGCCTTTCAGTATTGGTTCAGTGACCTATATCTTATCTAATCCATTCTATGTTGGTAAAATTCAATTCGCAAAG
TACAAAGATTGGAATGAAAAGCGTCGTAAAGGGCTGAATGATAAACCAATAATAGCTGAAGGTAAGCATTCCCCTATTAT
TATTCAAGACTTATGGGATAAAGTCCAATTACGTAAAAAACAAGTCAGTCAAAAACCTCAAGTCCACGGTAAAGGAACTA
ATCTATTAACAGGTATCGTTCATTGTCCACAATGTGGTGCACCAATGGCAGCTAGTAACACAACGAACACATTGAAAGAT
GGTACCAAGAAGCGAATACGTTATTATTCTTGCAGTAACTTCCGAAACAAAGGCTCAAAAGTATGTTCTGCGAATAGCGT
TAGAGCTGATGTGATTGAGAAATACGTCATGGATCAAATACTCGAAATTGTCAAAAGTGATAAAGTCATTAACCAAGTCT
TAGAACGTGTCAATCAAGAAAATAAAGTCGATATTGGTGCATTGAACCACGATATCGCTTATAAACAACAACAATACGAT
GAAGTCAGCGGGAAACTCCATAATTTAGTTAAAACCATTGAAGATAATCCGGACCTAACATCTGCATTGAAAGCAACTAT
TCATCAATATGAAACACAACTCAATGACATTACAAATCAAATGAATCAACTCAAACAGCAACAAAATCAAGAGAAACTAT
CTTATGATACGAAACAAATCGCTGCCCTATTACAACGAATATTTCAAAATATAGAATCAATGGATAAAGCACAACTCAAA
GCATTATATCTTACAGTCATTGACCGTATTGATATTCGTAAAGACGGTAATCATAAAAAACAGTTCTACGTTACACTAAA
ACTCAATAATGAAATTATTAAACAACTTTTCAATAATACCCCTCTCGACGAAGTGCTCCTCAGCACTTCGTCTTTATTTT
TGCCTCAAACGCTCTTTCTTCAAATCTAA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(11-156)

Recombinase (Recombinase)

(180-280)

Ogr/Delta-like zinc finger (Ogr_Delta)

(301-356)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrB Staphylococcus aureus N315

86.531

100

0.865

Multiple sequence alignment