Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   HKU488_RS06975 Genome accession   NZ_CP012045
Coordinates   1382573..1383214 (-) Length   213 a.a.
NCBI ID   WP_010922536.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain HKU488     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1377573..1388214
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HKU488_RS06950 (HKU488_01273) comFA/cflA 1377659..1378984 (-) 1326 WP_010922534.1 DEAD/DEAH box helicase Machinery gene
  HKU488_RS06955 (HKU488_01274) - 1379040..1379672 (+) 633 WP_009880468.1 YigZ family protein -
  HKU488_RS06960 (HKU488_01275) cysK 1379800..1380741 (+) 942 WP_010922535.1 cysteine synthase A -
  HKU488_RS06965 (HKU488_01276) - 1380759..1381136 (-) 378 WP_002991882.1 S1 RNA-binding domain-containing protein -
  HKU488_RS06970 (HKU488_01277) - 1381136..1382536 (-) 1401 WP_011285657.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  HKU488_RS06975 (HKU488_01278) vraR 1382573..1383214 (-) 642 WP_010922536.1 response regulator transcription factor Regulator
  HKU488_RS06980 (HKU488_01279) - 1383207..1384211 (-) 1005 WP_002991890.1 sensor histidine kinase -
  HKU488_RS06985 (HKU488_01280) liaF 1384208..1384900 (-) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  HKU488_RS06990 (HKU488_01281) pknB 1385023..1386921 (-) 1899 WP_010922538.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  HKU488_RS06995 (HKU488_01282) - 1386918..1387658 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23693.40 Da        Isoelectric Point: 5.3506

>NTDB_id=131032 HKU488_RS06975 WP_010922536.1 1382573..1383214(-) (vraR) [Streptococcus pyogenes strain HKU488]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVGDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=131032 HKU488_RS06975 WP_010922536.1 1382573..1383214(-) (vraR) [Streptococcus pyogenes strain HKU488]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGACATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGGTGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACATCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(148-202)

Response regulator receiver domain (Response_reg)

(6-118)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385