Detailed information
Bioinformatically predicted
Overview
| Name | comK/comK1 | Type | Regulator |
| Locus tag | KQ76_RS04660 | Genome accession | NZ_CP009361 |
| Coordinates | 970993..971562 (-) | Length | 189 a.a. |
| NCBI ID | WP_000287265.1 | Uniprot ID | A0A7U7EXU5 |
| Organism | Staphylococcus aureus strain ATCC 25923 | ||
| Function | promote expression of competence genes (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 971664..1008341 | 970993..971562 | flank | 102 |
Gene organization within MGE regions
Location: 970993..1008341
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KQ76_RS04660 (KQ76_04730) | comK/comK1 | 970993..971562 (-) | 570 | WP_000287265.1 | competence protein ComK | Regulator |
| KQ76_RS04665 (KQ76_04735) | - | 971772..971990 (+) | 219 | WP_000876825.1 | IDEAL domain-containing protein | - |
| KQ76_RS04670 (KQ76_04740) | - | 972071..973057 (-) | 987 | WP_000668822.1 | lipoate--protein ligase | - |
| KQ76_RS04675 (KQ76_04745) | - | 973256..973432 (+) | 177 | WP_000214898.1 | YkvS family protein | - |
| KQ76_RS04680 (KQ76_04750) | - | 973447..974049 (+) | 603 | WP_001033867.1 | type II CAAX prenyl endopeptidase Rce1 family protein | - |
| KQ76_RS15290 | - | 974365..974427 (+) | 63 | WP_240785570.1 | putative holin-like toxin | - |
| KQ76_RS04690 (KQ76_04760) | - | 974966..975067 (+) | 102 | WP_001790623.1 | hypothetical protein | - |
| KQ76_RS14410 | - | 975077..975349 (+) | 273 | WP_001794574.1 | lactococcin 972 family bacteriocin | - |
| KQ76_RS04695 (KQ76_04770) | - | 975393..977357 (+) | 1965 | WP_000870820.1 | bacteriocin-associated integral membrane family protein | - |
| KQ76_RS04700 (KQ76_04775) | - | 977360..977680 (+) | 321 | WP_000873929.1 | YxeA family protein | - |
| KQ76_RS04705 (KQ76_04780) | - | 977677..978318 (+) | 642 | WP_000571183.1 | ABC transporter ATP-binding protein | - |
| KQ76_RS14415 (KQ76_04785) | - | 978406..978696 (-) | 291 | WP_001791476.1 | hypothetical protein | - |
| KQ76_RS04715 (KQ76_04790) | - | 979037..979324 (+) | 288 | WP_000410718.1 | hypothetical protein | - |
| KQ76_RS04720 (KQ76_04795) | - | 979330..980811 (+) | 1482 | WP_000719183.1 | glycosyltransferase | - |
| KQ76_RS04725 (KQ76_04800) | - | 980901..981257 (-) | 357 | WP_000766009.1 | DoxX family protein | - |
| KQ76_RS04730 (KQ76_04805) | - | 981748..982470 (+) | 723 | Protein_908 | ABC transporter substrate-binding protein | - |
| KQ76_RS04735 (KQ76_04810) | - | 982524..982808 (+) | 285 | WP_000134551.1 | hypothetical protein | - |
| KQ76_RS04740 (KQ76_04815) | - | 982959..983279 (+) | 321 | WP_000805733.1 | DUF961 family protein | - |
| KQ76_RS04745 (KQ76_04820) | - | 983293..983595 (+) | 303 | WP_000386891.1 | hypothetical protein | - |
| KQ76_RS04750 (KQ76_04825) | - | 983770..984861 (+) | 1092 | WP_000172936.1 | replication initiation factor domain-containing protein | - |
| KQ76_RS04755 (KQ76_04830) | - | 984922..985989 (+) | 1068 | WP_000692013.1 | conjugal transfer protein | - |
| KQ76_RS04760 (KQ76_04835) | - | 985994..986254 (+) | 261 | WP_000015640.1 | TcpD family membrane protein | - |
| KQ76_RS04765 (KQ76_04840) | - | 986266..986649 (+) | 384 | WP_000358144.1 | TcpE family conjugal transfer membrane protein | - |
| KQ76_RS04770 (KQ76_04845) | - | 986684..989179 (+) | 2496 | WP_001049264.1 | ATP-binding protein | - |
| KQ76_RS04775 (KQ76_04850) | - | 989233..990591 (+) | 1359 | WP_001251204.1 | FtsK/SpoIIIE domain-containing protein | - |
| KQ76_RS04780 (KQ76_04855) | - | 990596..992443 (+) | 1848 | WP_000681144.1 | CD3337/EF1877 family mobilome membrane protein | - |
| KQ76_RS04785 (KQ76_04860) | - | 992433..993479 (+) | 1047 | WP_000247481.1 | CHAP domain-containing protein | - |
| KQ76_RS04790 (KQ76_04865) | - | 993486..994076 (+) | 591 | WP_000810442.1 | hypothetical protein | - |
| KQ76_RS04795 (KQ76_04870) | - | 994132..994473 (+) | 342 | WP_001255377.1 | cystatin-like fold lipoprotein | - |
| KQ76_RS14915 (KQ76_04875) | - | 994582..995085 (+) | 504 | WP_000746374.1 | transposase | - |
| KQ76_RS14920 (KQ76_04880) | - | 995114..995602 (+) | 489 | WP_232471205.1 | IS30 family transposase | - |
| KQ76_RS04810 (KQ76_04885) | - | 995816..996061 (+) | 246 | Protein_924 | ABC transporter substrate-binding protein | - |
| KQ76_RS04815 (KQ76_04890) | - | 996108..996239 (-) | 132 | WP_001794249.1 | SAR1012 family small protein | - |
| KQ76_RS04820 (KQ76_04895) | - | 996303..996518 (-) | 216 | WP_000867359.1 | TM2 domain-containing protein | - |
| KQ76_RS04825 (KQ76_04900) | - | 996683..997234 (+) | 552 | WP_000620943.1 | GNAT family N-acetyltransferase | - |
| KQ76_RS04830 (KQ76_04905) | - | 997286..998224 (-) | 939 | WP_000070966.1 | 1,4-dihydroxy-2-naphthoate polyprenyltransferase | - |
| KQ76_RS15195 | - | 998375..998452 (+) | 78 | WP_072357920.1 | hypothetical protein | - |
| KQ76_RS04835 (KQ76_04910) | - | 998445..999767 (+) | 1323 | WP_223200472.1 | isochorismate synthase | - |
| KQ76_RS04840 (KQ76_04915) | menD | 999754..1001427 (+) | 1674 | WP_000526678.1 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylic-acid synthase | - |
| KQ76_RS04845 (KQ76_04920) | menH | 1001414..1002217 (+) | 804 | WP_000150205.1 | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase | - |
| KQ76_RS04850 (KQ76_04925) | menB | 1002210..1003031 (+) | 822 | WP_000184947.1 | 1,4-dihydroxy-2-naphthoyl-CoA synthase | - |
| KQ76_RS04855 (KQ76_04930) | sspC | 1003267..1003596 (-) | 330 | WP_000284455.1 | staphostatin B | - |
| KQ76_RS04860 (KQ76_04935) | sspB | 1003634..1004815 (-) | 1182 | WP_001088793.1 | cysteine protease staphopain B | - |
| KQ76_RS04865 (KQ76_04940) | sspA | 1004897..1005970 (-) | 1074 | WP_000676568.1 | Glu-specific serine endopeptidase SspA | - |
| KQ76_RS04875 (KQ76_04950) | - | 1006498..1007652 (-) | 1155 | WP_000777562.1 | aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme | - |
Sequence
Protein
Download Length: 189 a.a. Molecular weight: 22601.83 Da Isoelectric Point: 9.6091
>NTDB_id=128902 KQ76_RS04660 WP_000287265.1 970993..971562(-) (comK/comK1) [Staphylococcus aureus strain ATCC 25923]
MYSQNIYVIRKGDMVIRPAFDDDDQRNGSEIIRFDKTRIQNPFKVQKIIERSCKFYGNTYLGKKAETNRITGISSKPPIL
LTPLFPTYFFPTHSDRQNENIWLNMHYIESIKELKNRKCKVTFINNESIILHVSYHSLWHQYNNSIFYYYMVDKQSRMIS
KNPDQPIDYNKATLNVFEALTRYSLFEDK
MYSQNIYVIRKGDMVIRPAFDDDDQRNGSEIIRFDKTRIQNPFKVQKIIERSCKFYGNTYLGKKAETNRITGISSKPPIL
LTPLFPTYFFPTHSDRQNENIWLNMHYIESIKELKNRKCKVTFINNESIILHVSYHSLWHQYNNSIFYYYMVDKQSRMIS
KNPDQPIDYNKATLNVFEALTRYSLFEDK
Nucleotide
Download Length: 570 bp
>NTDB_id=128902 KQ76_RS04660 WP_000287265.1 970993..971562(-) (comK/comK1) [Staphylococcus aureus strain ATCC 25923]
ATGTATTCTCAAAATATTTATGTGATACGCAAAGGAGACATGGTTATTCGACCAGCATTTGATGATGACGATCAAAGAAA
TGGTAGTGAAATAATTCGGTTTGACAAAACGCGTATTCAAAATCCTTTTAAAGTCCAGAAAATCATTGAACGCTCTTGCA
AATTTTATGGTAATACTTATCTTGGCAAGAAAGCAGAGACAAACCGCATTACTGGCATTTCTAGTAAACCACCTATTTTA
CTAACACCATTATTTCCAACTTATTTTTTCCCAACACATTCTGACAGACAAAATGAAAATATTTGGTTAAATATGCATTA
TATCGAAAGTATTAAAGAATTAAAAAATCGTAAATGTAAAGTGACATTTATTAATAATGAATCAATCATTCTTCATGTTT
CATACCACAGTTTATGGCACCAATATAACAATTCCATTTTTTACTATTACATGGTAGATAAACAATCTCGCATGATATCA
AAAAATCCCGACCAACCAATAGATTATAATAAAGCCACATTGAATGTGTTTGAAGCATTGACACGCTATTCTTTATTTGA
AGATAAATAA
ATGTATTCTCAAAATATTTATGTGATACGCAAAGGAGACATGGTTATTCGACCAGCATTTGATGATGACGATCAAAGAAA
TGGTAGTGAAATAATTCGGTTTGACAAAACGCGTATTCAAAATCCTTTTAAAGTCCAGAAAATCATTGAACGCTCTTGCA
AATTTTATGGTAATACTTATCTTGGCAAGAAAGCAGAGACAAACCGCATTACTGGCATTTCTAGTAAACCACCTATTTTA
CTAACACCATTATTTCCAACTTATTTTTTCCCAACACATTCTGACAGACAAAATGAAAATATTTGGTTAAATATGCATTA
TATCGAAAGTATTAAAGAATTAAAAAATCGTAAATGTAAAGTGACATTTATTAATAATGAATCAATCATTCTTCATGTTT
CATACCACAGTTTATGGCACCAATATAACAATTCCATTTTTTACTATTACATGGTAGATAAACAATCTCGCATGATATCA
AAAAATCCCGACCAACCAATAGATTATAATAAAGCCACATTGAATGTGTTTGAAGCATTGACACGCTATTCTTTATTTGA
AGATAAATAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comK/comK1 | Staphylococcus aureus MW2 |
100 |
100 |
1 |
| comK/comK1 | Staphylococcus aureus N315 |
100 |
100 |
1 |