Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpX   Type   Regulator
Locus tag   SP5448_RS05875 Genome accession   NZ_CP008776
Coordinates   1144550..1145779 (-) Length   409 a.a.
NCBI ID   WP_002984948.1    Uniprot ID   A0A4U7GJW1
Organism   Streptococcus pyogenes strain 5448     
Function   require for competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1139550..1150779
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SP5448_RS05855 (SP5448_06090) rpiA 1139831..1140514 (-) 684 WP_010922176.1 ribose-5-phosphate isomerase RpiA -
  SP5448_RS05860 (SP5448_06095) - 1140893..1142992 (+) 2100 WP_010922175.1 ATP-dependent Clp protease ATP-binding subunit -
  SP5448_RS05865 (SP5448_06100) - 1143050..1143793 (-) 744 WP_002984942.1 hypothetical protein -
  SP5448_RS05870 (SP5448_06105) yihA 1143941..1144540 (-) 600 WP_002984945.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
  SP5448_RS05875 (SP5448_06110) clpX 1144550..1145779 (-) 1230 WP_002984948.1 ATP-dependent Clp protease ATP-binding subunit ClpX Regulator
  SP5448_RS09390 (SP5448_06115) - 1145909..1146079 (-) 171 WP_002984950.1 hypothetical protein -
  SP5448_RS05885 (SP5448_06120) - 1146099..1146596 (-) 498 WP_011285487.1 dihydrofolate reductase -
  SP5448_RS05890 (SP5448_06125) - 1146676..1147515 (-) 840 WP_010922172.1 thymidylate synthase -
  SP5448_RS05895 (SP5448_06130) - 1147724..1148899 (+) 1176 WP_010922171.1 hydroxymethylglutaryl-CoA synthase -
  SP5448_RS05900 (SP5448_06135) - 1148886..1150163 (+) 1278 WP_010922170.1 hydroxymethylglutaryl-CoA reductase, degradative -

Sequence

Protein


Download         Length: 409 a.a.        Molecular weight: 44991.44 Da        Isoelectric Point: 4.5775

>NTDB_id=124147 SP5448_RS05875 WP_002984948.1 1144550..1145779(-) (clpX) [Streptococcus pyogenes strain 5448]
MAGSRTNDIKVYCSFCGKSQDDVKKIIAGNNVFICNECVALSQEIIKEELAEEVLADLTEVPKPKELLDVLNQYVVGQDR
AKRALSVAVYNHYKRVSFTESRDDDDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENI
LLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTK
NILFIVGGAFDGIEEIVKQRLGEKVIGFGQNSRKIDDNASYMQEIISEDIQKFGLIPEFIGRLPVVAALEQLNTSDLIQI
LTEPRNALVKQYQALLSYDGVELAFDKEALEAIANKAIERKTGARGLRSIIEETMLDIMFEIPSQEDVTKVRITKAAVEG
KSKPVLETA

Nucleotide


Download         Length: 1230 bp        

>NTDB_id=124147 SP5448_RS05875 WP_002984948.1 1144550..1145779(-) (clpX) [Streptococcus pyogenes strain 5448]
ATGGCAGGAAGTAGAACTAACGATATTAAAGTATACTGTTCATTTTGTGGTAAAAGCCAGGATGACGTTAAAAAAATTAT
CGCAGGAAATAATGTTTTCATCTGCAATGAATGCGTAGCTTTATCACAAGAAATTATAAAAGAAGAATTGGCTGAAGAAG
TCCTTGCCGATTTGACAGAAGTTCCAAAACCAAAAGAGCTCCTTGATGTTTTAAATCAATATGTGGTTGGTCAAGATCGT
GCTAAACGTGCTTTATCAGTTGCTGTGTACAATCATTATAAGCGTGTCTCGTTTACAGAAAGTCGTGATGACGATGATGT
GGATTTACAAAAGTCCAACATTTTGATGATTGGACCAACAGGTTCAGGAAAAACCTTCTTAGCACAAACTCTGGCTAAAA
GCCTCAATGTACCATTTGCTATTGCAGATGCAACTTCTTTGACTGAAGCAGGGTATGTTGGAGAAGATGTGGAAAATATT
TTACTCAAACTGATTCAGGCTGCTGACTATAATGTCGAACGAGCAGAGCGTGGTATTATTTATGTTGATGAAATAGATAA
GATTGCTAAAAAAGGTGAGAACGTATCTATCACACGTGATGTATCTGGTGAAGGTGTACAGCAAGCCCTTCTTAAAATTA
TTGAAGGTACGGTAGCAAGTGTTCCCCCACAAGGTGGGCGGAAGCACCCTAATCAAGAAATGATCCAAATTGATACAAAA
AATATCTTGTTTATTGTTGGCGGGGCTTTTGATGGCATCGAGGAGATCGTTAAACAACGTTTAGGTGAAAAAGTTATTGG
TTTTGGTCAAAACAGCCGTAAAATTGATGACAATGCTTCTTATATGCAAGAAATTATTTCAGAAGATATTCAAAAGTTTG
GGCTTATTCCAGAATTTATTGGCCGCTTACCAGTTGTGGCAGCCCTTGAACAACTAAACACATCAGATTTGATTCAAATT
TTGACAGAACCAAGAAATGCCCTGGTCAAGCAATATCAGGCTCTTCTTTCTTACGATGGCGTCGAATTGGCATTTGATAA
GGAAGCCTTAGAAGCCATTGCCAATAAAGCCATTGAACGTAAGACAGGAGCACGTGGTCTTCGTTCTATTATCGAAGAAA
CGATGCTTGACATCATGTTTGAAATTCCAAGCCAAGAAGATGTCACAAAAGTGCGTATCACCAAGGCTGCTGTCGAAGGC
AAGTCAAAACCCGTTTTAGAGACAGCTTAA

Domains

Predicted by InterproScan.

AAA domain (Cdc48 subfamily) (AAA_2)

(110-305)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(312-391)

ClpX C4-type zinc finger (zf-C4_ClpX)

(12-48)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4U7GJW1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpX Streptococcus mutans UA159

88.998

100

0.89
  clpX Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

58.603

98.044

0.575

Multiple sequence alignment