Detailed information NTG0123572

Bioinformatically predicted

Overview

• Name: clpX
• Type: Regulator
• Locus tag: FE90_RS01950
• Genome accession: NZ_CP008695
• Coordinates: 361689..362918 (+)
• Length: 409 a.a.
• NCBI ID: WP_011888976.1
• Uniprot ID: A2RF17
• Organism: Streptococcus pyogenes strain M23ND
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 356689..367918

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FE90_RS01925 (FE90_0365)	-	357305..358582 (-)	1278	WP_002984963.1	hydroxymethylglutaryl-CoA reductase, degradative	-
FE90_RS01930 (FE90_0366)	-	358569..359744 (-)	1176	WP_011888977.1	hydroxymethylglutaryl-CoA synthase	-
FE90_RS01935 (FE90_0367)	-	359953..360792 (+)	840	WP_011017679.1	thymidylate synthase	-
FE90_RS01940 (FE90_0368)	-	360872..361369 (+)	498	WP_011184412.1	dihydrofolate reductase	-
FE90_RS09940	-	361389..361559 (+)	171	WP_002990165.1	hypothetical protein	-
FE90_RS01950 (FE90_0369)	clpX	361689..362918 (+)	1230	WP_011888976.1	ATP-dependent Clp protease ATP-binding subunit ClpX	Regulator
FE90_RS01955 (FE90_0370)	yihA	362928..363527 (+)	600	WP_011184414.1	ribosome biogenesis GTP-binding protein YihA/YsxC	-
FE90_RS01960 (FE90_0371)	-	363675..364418 (+)	744	WP_002984942.1	hypothetical protein	-
FE90_RS01965 (FE90_0372)	-	364476..366575 (-)	2100	WP_002984939.1	AAA family ATPase	-
FE90_RS01970 (FE90_0373)	rpiA	366953..367636 (+)	684	WP_009881270.1	ribose-5-phosphate isomerase RpiA	-

Sequence

Protein

• Length: 409 a.a.
• Molecular weight: 45006.50 Da
• Isoelectric Point: 4.6184

>NTDB_id=123572 FE90_RS01950 WP_011888976.1 361689..362918(+) (clpX) [Streptococcus pyogenes strain M23ND]
MAGSRTNDIKVYCSFCGKSQDDVKKIIAGNNVFICNECVALSQEIIKEELAEEVLADLTEVPKPKELLDVLNQYVVGQDR
AKRALSVAVYNHYKRVSFTESRDDDDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENI
LLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTK
NILFIVGGAFDGIEEIVKQRLGEKVIGFGQNSRKIDDNASYMQEIISEDIQKFGLIPEFIGRLPVVAALEQLNTSDLIRI
LTEPRNALVKQYQALLSYDGVELEFDKAALEAIATKAIERKTGARGLRSIIEETMLDIMFEIPSQEDVTKVRITKAAVEG
KSKPVLETA

Nucleotide

• Length: 1230 bp

>NTDB_id=123572 FE90_RS01950 WP_011888976.1 361689..362918(+) (clpX) [Streptococcus pyogenes strain M23ND]
ATGGCAGGAAGTAGAACTAACGATATTAAAGTATACTGTTCATTTTGTGGTAAAAGCCAGGATGACGTTAAAAAAATTAT
CGCAGGAAATAATGTTTTCATCTGCAATGAATGCGTAGCTTTATCACAAGAAATTATAAAAGAAGAATTGGCTGAAGAAG
TCCTTGCCGATTTGACAGAAGTTCCAAAACCAAAAGAGCTCCTTGATGTTTTAAATCAATATGTGGTTGGTCAAGATCGT
GCTAAACGTGCTTTATCAGTTGCTGTGTACAATCATTATAAGCGTGTCTCGTTTACAGAAAGTCGTGATGACGATGATGT
GGATTTACAAAAGTCTAACATTTTGATGATTGGACCAACAGGTTCAGGAAAAACCTTCTTAGCACAAACTCTGGCTAAAA
GCCTCAATGTACCATTTGCTATTGCAGATGCAACTTCTTTGACTGAAGCAGGGTATGTTGGAGAAGATGTGGAAAATATT
TTACTCAAACTGATTCAGGCTGCTGACTATAATGTCGAACGAGCAGAGCGTGGTATTATTTATGTTGATGAAATAGATAA
GATTGCTAAAAAAGGTGAGAACGTATCTATCACACGTGATGTATCTGGTGAAGGTGTACAGCAAGCCCTTCTTAAAATTA
TTGAAGGTACGGTAGCAAGTGTTCCCCCACAAGGTGGGCGGAAGCACCCTAATCAAGAAATGATCCAAATTGATACAAAA
AATATCTTGTTTATTGTTGGCGGGGCTTTTGATGGCATCGAGGAGATTGTTAAACAACGTTTAGGTGAAAAAGTTATTGG
TTTTGGTCAAAACAGCCGTAAAATTGATGACAATGCTTCTTATATGCAAGAAATTATTTCAGAAGATATTCAAAAGTTTG
GGCTTATTCCAGAATTTATTGGCCGCTTACCAGTTGTGGCAGCCCTTGAACAACTAAACACATCAGATTTGATTCGAATC
TTAACAGAGCCAAGGAATGCTCTTGTCAAGCAATATCAGGCCCTTCTTTCCTATGATGGGGTTGAATTAGAATTTGATAA
AGCAGCTCTTGAAGCTATCGCAACTAAAGCCATTGAACGTAAGACAGGAGCACGTGGTCTTCGTTCTATTATCGAAGAAA
CGATGCTTGACATCATGTTTGAAATTCCAAGCCAAGAAGATGTCACAAAAGTGCGTATCACCAAGGCTGCTGTCGAAGGC
AAGTCAAAACCCGTTTTAGAGACAGCTTAA

Domains

Predicted by InterproScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (110-305)

• ClpX C4-type zinc finger (zf-C4_ClpX) (12-48)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (312-391)

3D structure

• AlphaFold DB: A2RF17

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpX	Streptococcus mutans UA159	88.998	100	0.89
clpX	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	58.853	98.044	0.577