Detailed information    

insolico Bioinformatically predicted

Overview

Name   comB4   Type   Machinery gene
Locus tag   EG63_RS00105 Genome accession   NZ_CP007604
Coordinates   14009..16372 (+) Length   787 a.a.
NCBI ID   WP_038417097.1    Uniprot ID   -
Organism   Helicobacter pylori strain BM013A     
Function   transformation-associated type IV transport system (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 9009..21372
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EG63_RS00075 (EG63_00075) groES 9030..9386 (-) 357 WP_000671934.1 co-chaperone GroES -
  EG63_RS00080 (EG63_00085) dnaG 9673..11352 (+) 1680 WP_038417094.1 DNA primase -
  EG63_RS00085 (EG63_00090) - 11349..12401 (+) 1053 WP_038417095.1 MnmA/TRMU family protein -
  EG63_RS00090 (EG63_00095) - 12490..13317 (+) 828 WP_038417096.1 DUF5718 family protein -
  EG63_RS00095 (EG63_00100) comB2 13463..13744 (+) 282 WP_001272691.1 TrbC/VirB2 family protein Machinery gene
  EG63_RS00100 (EG63_00105) comB3 13744..14007 (+) 264 WP_000584956.1 hypothetical protein Machinery gene
  EG63_RS00105 (EG63_00110) comB4 14009..16372 (+) 2364 WP_038417097.1 VirB4 family type IV secretion/conjugal transfer ATPase Machinery gene
  EG63_RS00110 (EG63_00115) - 16678..18018 (+) 1341 WP_038417098.1 COG3014 family protein -
  EG63_RS00115 (EG63_00120) cheV1 18117..19082 (+) 966 WP_038417099.1 chemotaxis protein CheV1 -
  EG63_RS00120 (EG63_00125) nspC 19079..20296 (+) 1218 WP_038417100.1 carboxynorspermidine decarboxylase -
  EG63_RS00125 (EG63_00130) lpxE 20306..20839 (-) 534 WP_236620587.1 lipid A 1-phosphatase LpxE -

Sequence

Protein


Download         Length: 787 a.a.        Molecular weight: 90264.88 Da        Isoelectric Point: 8.4101

>NTDB_id=121560 EG63_RS00105 WP_038417097.1 14009..16372(+) (comB4) [Helicobacter pylori strain BM013A]
MLEKLLGTIKQKVSNYFLGVLPKSYSMSEENNILGLYDEHFLLTKNENLVGILRLEGVSYTHLSTEQLQDLFTERQMALD
SLEKVVVRLVVKRRKIDYKQNIQADSQYLQAILNQFENKEVYENQYFLVLESTHSLQGVLEHKKKSLMHANRENFKDILS
YKAHFLQETLKSLEIQLKNYAPKLLSSKEVLNFYAEYINGFDLPLKPLVGGYLSDSYIASSITFEKDYFIQESFNQKTYN
RLIGIKAYESERITSIAVGVLLYQETPLDIIFSIEPMSVNKTLGFLKERAKFSMSNLVKNELLEYQELVKTKRLSMQKFA
LNILIKAPSLEDLDAQTSLILGLLFKENLVGVIETFGLKGGYFSFFPERIHLNHRLRFLTSKALACLMVFERQNLGFKAN
SWGNSPLSVFKNLDYSPFLFNFHNQEVSHNNAKEIARVNGHTLIIGATGSGKSTLISFLMMSALKYQNMRLLAFDRMQGL
YSFTKFFKGHYHDGQSFSINPFCLEPNLQNLEFLQSFFLSMLDLAPSRDKEALEDMNAVSCAIKSLYETLYPKDFSLLDF
KETLKRTSSNQLSLSLEPYLNNPLFNALNDAFNSNAFLNVINLDAITQNPKDLGLLAYYLFYKILEESRKNDSGFLVFLD
EFKSYVENDLLNTKINALITQARKANGVVVLALQDIYQLSGVKNAHSFLSNMGTLILYPQKNARELKHHFNVPLSETEIS
FLENTPLYARQVLVKNLGNGSSNMIDVSLEGLGRYLKIFNSDSSHVNKVKALQKDYPTEWREKLLKS

Nucleotide


Download         Length: 2364 bp        

>NTDB_id=121560 EG63_RS00105 WP_038417097.1 14009..16372(+) (comB4) [Helicobacter pylori strain BM013A]
ATGTTAGAAAAGCTTTTAGGCACTATCAAACAAAAAGTTTCAAACTATTTTTTAGGGGTTTTGCCTAAAAGCTATTCTAT
GAGCGAAGAAAACAACATTTTAGGCTTGTATGATGAGCATTTTTTACTCACTAAAAACGAAAACTTAGTGGGCATCCTCC
GTTTAGAGGGGGTGAGTTACACCCATTTAAGCACAGAGCAATTGCAAGATCTTTTCACCGAGCGCCAGATGGCGTTGGAT
TCTTTAGAAAAAGTCGTGGTGCGCCTTGTGGTTAAAAGGCGTAAAATTGATTATAAACAAAACATTCAAGCTGACTCTCA
ATACTTGCAAGCGATTTTGAATCAATTTGAAAATAAAGAAGTGTATGAGAATCAGTATTTTTTAGTTTTAGAAAGCACGC
ACTCCTTACAAGGTGTTTTGGAGCATAAGAAAAAATCTCTCATGCATGCCAATAGGGAAAATTTTAAGGATATTCTCTCT
TATAAAGCGCATTTTTTGCAAGAAACTTTAAAAAGCTTAGAAATCCAGCTCAAAAATTATGCCCCCAAACTCTTAAGCTC
CAAAGAGGTTTTGAATTTTTACGCAGAATACATTAATGGGTTTGATCTCCCTTTAAAGCCCCTAGTAGGGGGGTATTTGA
GCGATAGCTATATCGCTAGTTCTATCACTTTTGAAAAAGATTATTTCATTCAAGAGAGCTTTAATCAAAAAACCTACAAC
CGCTTGATTGGCATTAAAGCTTATGAGAGCGAAAGGATCACTTCTATAGCGGTGGGAGTGCTTTTATACCAAGAGACGCC
ACTAGATATTATCTTTTCTATAGAGCCTATGAGCGTCAATAAAACGCTGGGTTTTTTAAAAGAGAGGGCCAAATTTAGCA
TGTCCAATCTCGTTAAAAACGAGCTGCTAGAATACCAAGAATTAGTCAAAACCAAACGCCTATCCATGCAAAAATTCGCC
CTAAACATTCTTATCAAAGCCCCCAGTTTAGAGGATTTAGACGCTCAAACCAGCTTAATTTTAGGGCTTTTATTTAAAGA
AAACTTAGTGGGCGTTATAGAAACTTTTGGCTTGAAAGGGGGGTATTTTTCCTTTTTCCCTGAACGCATCCATTTAAACC
ACCGCTTGCGCTTTTTAACTTCTAAAGCCCTAGCGTGTTTGATGGTGTTTGAAAGGCAAAATTTAGGCTTTAAGGCTAAT
TCATGGGGGAATAGCCCTTTGAGCGTGTTTAAAAATTTGGATTATTCCCCTTTTTTATTCAATTTCCACAACCAAGAAGT
GAGCCACAACAACGCTAAAGAAATCGCTAGAGTGAATGGGCATACTCTAATCATAGGGGCTACTGGGAGCGGTAAAAGCA
CGCTGATTAGCTTTTTAATGATGAGCGCTTTGAAATACCAAAACATGCGCCTTTTAGCTTTTGACAGGATGCAAGGGCTG
TATTCTTTCACAAAATTTTTTAAAGGGCATTACCATGACGGCCAATCTTTTAGCATTAACCCCTTTTGTTTAGAGCCTAA
TTTGCAGAATCTAGAATTTTTGCAATCCTTCTTTTTGAGCATGCTTGATCTTGCCCCTTCAAGGGATAAAGAAGCCTTAG
AAGACATGAATGCGGTTTCTTGTGCGATTAAGAGCCTTTATGAGACTTTATACCCTAAAGATTTTAGTTTGCTAGACTTT
AAAGAAACGCTTAAAAGAACCTCATCTAACCAACTAAGCTTGAGCTTGGAGCCGTATTTGAATAACCCCCTTTTTAACGC
TTTGAATGACGCATTCAATTCCAACGCTTTTTTAAATGTAATCAACTTAGACGCTATCACCCAAAACCCTAAAGACTTAG
GGCTTTTAGCCTATTACTTGTTTTATAAAATTTTAGAAGAATCCAGGAAAAACGACAGCGGCTTTTTGGTTTTTTTAGAC
GAGTTTAAATCCTATGTGGAAAACGATTTATTGAACACTAAAATTAACGCTTTAATCACGCAAGCCAGAAAAGCTAATGG
CGTGGTGGTGTTGGCTTTGCAAGATATTTACCAATTAAGCGGGGTTAAAAACGCTCATAGTTTTTTAAGCAACATGGGGA
CTCTCATTTTGTATCCGCAAAAAAACGCTAGGGAGTTGAAACACCATTTCAATGTGCCTTTGAGCGAAACTGAAATTTCT
TTTTTAGAAAACACCCCTTTGTATGCCAGGCAGGTTTTAGTCAAAAATCTGGGTAATGGGAGCTCTAACATGATTGATGT
GAGTTTGGAGGGCTTGGGGCGTTATTTGAAAATCTTTAATTCAGACTCTAGCCATGTCAATAAAGTGAAAGCGTTACAAA
AAGACTACCCTACAGAGTGGCGTGAGAAACTTTTGAAGAGCTAG

Domains

Predicted by InterproScan.

CagE, TrbE, VirB family, component of type IV transporter system (CagE_TrbE_VirB)

(176-375)

FtsK/SpoIIIE family (FtsK_SpoIIIE)

(426-466)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comB4 Helicobacter pylori 26695

96.95

100

0.97

Multiple sequence alignment