Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   CH51_RS00210 Genome accession   NZ_CP007499
Coordinates   49496..50845 (-) Length   449 a.a.
NCBI ID   WP_000815638.1    Uniprot ID   Q53IL8
Organism   Staphylococcus aureus strain 2395 USA500     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 41081..58241 49496..50845 within 0


Gene organization within MGE regions


Location: 41081..58241
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CH51_RS00170 (CH51_00170) mecA 41081..43090 (-) 2010 WP_063852655.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  CH51_RS00175 (CH51_00175) - 43187..44173 (+) 987 WP_001549960.1 beta-lactam sensor/signal transducer MecR1 -
  CH51_RS00180 (CH51_00180) - 44163..44405 (+) 243 Protein_33 type I restriction enzyme endonuclease domain-containing protein -
  CH51_RS00185 (CH51_00185) - 44396..46006 (-) 1611 Protein_34 IS1182 family transposase -
  CH51_RS00190 (CH51_00190) - 46055..46561 (-) 507 WP_001092188.1 DUF1643 domain-containing protein -
  CH51_RS00195 (CH51_00195) - 46576..46887 (-) 312 WP_000700851.1 DUF960 family protein -
  CH51_RS00200 (CH51_00205) - 46974..47324 (-) 351 WP_000849672.1 SAUGI family uracil-DNA glycosylase inhibitor -
  CH51_RS00205 (CH51_00210) ccrB 47846..49474 (-) 1629 WP_001186608.1 cassette chromosome recombinase CcrB Machinery gene
  CH51_RS00210 (CH51_00215) ccrA 49496..50845 (-) 1350 WP_000815638.1 cassette chromosome recombinase CcrA Machinery gene
  CH51_RS00215 (CH51_00220) cch1 51079..52872 (-) 1794 WP_000195099.1 cassette chromosome replicative helicase -
  CH51_RS00220 (CH51_00225) ssb 52872..53165 (-) 294 WP_000182688.1 cassette chromosome ssDNA-binding protein -
  CH51_RS00225 (CH51_00230) - 53321..54388 (+) 1068 WP_001099283.1 hypothetical protein -
  CH51_RS00230 (CH51_00235) - 54406..55920 (+) 1515 WP_000627204.1 protein kinase domain-containing protein -
  CH51_RS16585 - 55920..56069 (+) 150 WP_000369743.1 hypothetical protein -
  CH51_RS16650 - 56371..56613 (+) 243 WP_001632591.1 zinc ribbon domain-containing protein -
  CH51_RS00240 (CH51_00245) - 56778..58241 (+) 1464 WP_001632592.1 hypothetical protein -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52636.23 Da        Isoelectric Point: 9.9639

>NTDB_id=119992 CH51_RS00210 WP_000815638.1 49496..50845(-) (ccrA) [Staphylococcus aureus strain 2395 USA500]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQITQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRLKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYDYH
HGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQTKQTSSDNQLKQKIKCPCCNATLTNMTIRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKSAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHIIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=119992 CH51_RS00210 WP_000815638.1 49496..50845(-) (ccrA) [Staphylococcus aureus strain 2395 USA500]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGTCGCAAAGATAATCGTAGTGGGT
ATCGACAAATAACACAATTAATTCAACAAGGACAGTGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACGTACCATGTTCATATCTTAAGCGTACATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGACTCAAGCTTAATATCTTCATCAGTTTAGCCGAACTTGAATCGGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACACATGCACCTTTTGGTTACGATTATCAC
CACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGCCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAACCAAACAGACATCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCATTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAAGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATTGATGCAGAAACGTTCA
GAGAGCAAACACAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGGCATCAAATACAACACATCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATTGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase (Recombinase)

(169-250)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-321)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q53IL8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus N315

97.55

100

0.976
  ccrA Staphylococcus aureus COL

75.501

100

0.755

Multiple sequence alignment