Detailed information NTG0119492

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: CH52_RS09950
• Genome accession: NZ_CP007454
• Coordinates: 1950741..1951784 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 502A isolate RN6607
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1945741..1956784

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CH52_RS09915	-	1946167..1946277 (+)	111	WP_001790257.1	hypothetical protein	-
CH52_RS09920 (CH52_09475)	-	1946306..1946719 (+)	414	WP_001557448.1	hypothetical protein	-
CH52_RS09925 (CH52_09480)	-	1947150..1948136 (-)	987	WP_000999717.1	FUSC family protein	-
CH52_RS09935 (CH52_09485)	map	1948667..1949425 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
CH52_RS09940 (CH52_09490)	-	1949642..1950028 (+)	387	WP_001110179.1	hypothetical protein	-
CH52_RS09945 (CH52_09495)	liaF	1950043..1950744 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
CH52_RS09950 (CH52_09500)	vraS	1950741..1951784 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
CH52_RS09955 (CH52_09505)	vraR	1951774..1952403 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
CH52_RS09960 (CH52_09510)	-	1952516..1953733 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
CH52_RS09965 (CH52_09515)	-	1954011..1954286 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
CH52_RS09970 (CH52_09520)	-	1954293..1954757 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
CH52_RS09975 (CH52_09525)	-	1954904..1955104 (+)	201	WP_000180460.1	DUF1128 family protein	-
CH52_RS09980 (CH52_09530)	-	1955107..1956363 (+)	1257	WP_001795108.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=119492 CH52_RS09950 WP_001017131.1 1950741..1951784(+) (vraS) [Staphylococcus aureus strain 502A isolate RN6607]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=119492 CH52_RS09950 WP_001017131.1 1950741..1951784(+) (vraS) [Staphylococcus aureus strain 502A isolate RN6607]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1