Detailed information NTG1170433

Bioinformatically predicted

Overview

• Name: clpX
• Type: Regulator
• Locus tag: ACLV7W_RS02890
• Genome accession: NZ_OZ217346
• Coordinates: 587423..588655 (+)
• Length: 410 a.a.
• NCBI ID: WP_012972566.1
• Uniprot ID: A0A387B487
• Organism: Streptococcus mitis isolate S. mitis D22
• Function: require for competence development (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Prophage	566523..587216	587423..588655	flank	207

Gene organization within MGE regions

Location: 566523..588655

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7W_RS02825 (SMID22_05790)	-	566523..567233 (+)	711	WP_000062200.1	ABC transporter ATP-binding protein	-
ACLV7W_RS02830 (SMID22_05800)	-	567397..568959 (-)	1563	Protein_538	IS1182 family transposase	-
ACLV7W_RS02835	-	569098..570449 (+)	1352	WP_134813905.1	IS3 family transposase	-
ACLV7W_RS02840	-	570587..572074 (+)	1488	Protein_540	IS1182 family transposase	-
ACLV7W_RS02845 (SMID22_05840)	-	572406..573584 (+)	1179	WP_411865400.1	YSIRK-type signal peptide-containing protein	-
ACLV7W_RS02850 (SMID22_05850)	-	573808..579615 (+)	5808	WP_411865401.1	Rib/alpha-like domain-containing protein	-
ACLV7W_RS02855 (SMID22_05860)	-	579695..580951 (-)	1257	WP_411865402.1	ISL3 family transposase	-
ACLV7W_RS02860 (SMID22_05870)	-	581176..582033 (+)	858	WP_194251556.1	bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase	-
ACLV7W_RS02870 (SMID22_05900)	-	583699..584955 (-)	1257	WP_411865403.1	ISL3 family transposase	-
ACLV7W_RS02875 (SMID22_05910)	-	585101..586498 (-)	1398	Protein_547	IS1182 family transposase	-
ACLV7W_RS02880 (SMID22_05930)	-	586710..587216 (+)	507	WP_070842829.1	dihydrofolate reductase	-
ACLV7W_RS02885 (SMID22_05940)	-	587216..587386 (+)	171	WP_000442260.1	hypothetical protein	-
ACLV7W_RS02890 (SMID22_05950)	clpX	587423..588655 (+)	1233	WP_012972566.1	ATP-dependent Clp protease ATP-binding subunit ClpX	Regulator

Sequence

Protein

• Length: 410 a.a.
• Molecular weight: 45681.16 Da
• Isoelectric Point: 4.4240

>NTDB_id=1170433 ACLV7W_RS02890 WP_012972566.1 587423..588655(+) (clpX) [Streptococcus mitis isolate S. mitis D22]
MPTNRNNDMMVYCSFCGKSQEEVQKIIAGNNAFICNECVELAQEIIREELAEEVLADLSEVPKPIELLHILNHYVIGQDR
AKRALAVAVYNHYKRINFHDTREESEDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATALTEAGYVGEDVEN
ILLKLLQAADFNIERAERGIIYVDEIDKIAKKSENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPQQEMIQVDT
KNILFIVGGAFDGIEEIVKQRLGEKVIGFGQNNKAIDENSSYMQEIIAEDIQKFGIIPELIGRLPVFAALEQLTVDDLVR
ILKEPRNALVKQYQTLLSYDDVELEFDDEALQEIANKAIERKTGARGLRSIIEETMLDVMFEVPSQENVKLVRITKEAVD
GTDKPILETA

Nucleotide

• Length: 1233 bp

>NTDB_id=1170433 ACLV7W_RS02890 WP_012972566.1 587423..588655(+) (clpX) [Streptococcus mitis isolate S. mitis D22]
ATGCCTACAAATAGGAATAATGATATGATGGTTTATTGCTCATTTTGTGGCAAAAGCCAAGAAGAAGTACAAAAAATAAT
CGCAGGCAACAACGCCTTTATCTGTAATGAATGTGTGGAGTTGGCTCAGGAAATCATTCGAGAGGAGTTGGCGGAAGAAG
TCTTGGCAGACTTGTCTGAAGTTCCAAAACCAATCGAACTCCTCCATATCTTGAACCACTATGTAATCGGTCAAGATCGT
GCCAAGCGTGCCTTGGCAGTGGCGGTTTACAACCACTACAAACGCATCAATTTCCACGATACGCGTGAAGAGTCGGAAGA
TGTAGATTTGCAGAAGTCAAATATCTTGATGATTGGCCCAACTGGTTCAGGGAAAACTTTCCTTGCCCAGACCTTGGCTA
AGAGCTTGAATGTGCCTTTTGCGATTGCGGATGCAACAGCTCTTACTGAGGCTGGTTATGTTGGTGAGGATGTGGAAAAT
ATCCTCCTCAAACTCCTGCAGGCTGCTGACTTTAACATTGAACGTGCAGAGCGTGGCATTATCTACGTGGATGAAATTGA
TAAGATTGCCAAGAAGAGCGAGAACGTGTCTATCACACGTGATGTTTCTGGTGAAGGGGTGCAACAAGCCCTTCTCAAGA
TTATCGAGGGAACTGTTGCTAGCGTGCCGCCTCAAGGTGGACGAAAACATCCGCAACAAGAGATGATTCAAGTAGATACC
AAAAACATCCTCTTCATCGTGGGTGGTGCCTTTGATGGTATTGAAGAAATCGTCAAACAACGTCTGGGTGAAAAAGTCAT
CGGATTTGGTCAAAACAATAAAGCGATTGATGAAAACAGCTCTTACATGCAAGAAATCATCGCTGAAGATATTCAAAAAT
TTGGTATTATCCCTGAGTTGATTGGACGTTTGCCTGTCTTTGCAGCTCTTGAGCAATTAACGGTTGATGACTTGGTGCGC
ATTTTGAAAGAGCCAAGAAATGCTTTGGTGAAACAGTACCAAACCTTGCTTTCTTACGATGATGTCGAGTTGGAATTTGA
CGACGAAGCTCTTCAAGAGATTGCCAATAAAGCCATCGAACGCAAAACTGGTGCGCGTGGTCTTCGCTCCATCATCGAAG
AAACCATGCTAGACGTCATGTTTGAAGTACCGAGTCAGGAAAATGTGAAATTGGTTCGCATCACAAAAGAAGCTGTCGAT
GGAACGGATAAACCAATCTTGGAAACAGCCTAG

Domains

Predicted by InterproScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (111-306)

• ClpX C4-type zinc finger (zf-C4_ClpX) (12-48)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (313-390)

3D structure

• AlphaFold DB: A0A387B487

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpX	Streptococcus mutans UA159	87.073	100	0.871
clpX	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	57.463	98.049	0.563