Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   ACLV7H_RS08260 Genome accession   NZ_OZ217340
Coordinates   1609491..1610180 (-) Length   229 a.a.
NCBI ID   WP_007520625.1    Uniprot ID   A0A1X1GGK8
Organism   Streptococcus oralis isolate S. oralis A22     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1604491..1615180
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7H_RS08240 (SORA22_16590) - 1605471..1606478 (-) 1008 WP_411866897.1 phosphomevalonate kinase -
  ACLV7H_RS08245 (SORA22_16600) mvaD 1606465..1607418 (-) 954 WP_411866898.1 diphosphomevalonate decarboxylase -
  ACLV7H_RS08250 (SORA22_16610) mvk 1607400..1608278 (-) 879 WP_045593183.1 mevalonate kinase -
  ACLV7H_RS08255 (SORA22_16620) cbpF 1608396..1609391 (-) 996 WP_411866899.1 choline-binding protein CbpF -
  ACLV7H_RS08260 (SORA22_16630) covR 1609491..1610180 (-) 690 WP_007520625.1 DNA-binding response regulator Regulator
  ACLV7H_RS08265 (SORA22_16640) gndA 1610192..1611616 (-) 1425 WP_049484246.1 NADP-dependent phosphogluconate dehydrogenase -
  ACLV7H_RS08270 (SORA22_16650) mapZ 1611692..1613143 (-) 1452 WP_045593174.1 cell division site-positioning protein MapZ -
  ACLV7H_RS08275 (SORA22_16660) - 1613156..1614313 (-) 1158 WP_411866900.1 THUMP domain-containing class I SAM-dependent RNA methyltransferase -
  ACLV7H_RS08285 (SORA22_16690) gpsB 1614798..1615127 (-) 330 WP_045593171.1 cell division regulator GpsB -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26812.97 Da        Isoelectric Point: 8.0271

>NTDB_id=1169975 ACLV7H_RS08260 WP_007520625.1 1609491..1610180(-) (covR) [Streptococcus oralis isolate S. oralis A22]
MGKRILLLEKERNLAHFLSLELQKEQYRVDLVEEGQKALSMALQTDYDLILLNARLGDMTAQDFAERLSRTKPASVIMVL
DHREELQDQIETIQRFAVSYIYKPVIIDNLVARISAIFRGRDFIDQHCSQMKVPTSYRNLRMDVEHHTVYRGEEMIALTR
REYDLLATLMGSKKVLTREQLLESVWKYESATETNIVDVYIRYLRSKLDVKGQKSYIKTVRGVGYTMQE

Nucleotide


Download         Length: 690 bp        

>NTDB_id=1169975 ACLV7H_RS08260 WP_007520625.1 1609491..1610180(-) (covR) [Streptococcus oralis isolate S. oralis A22]
ATGGGGAAACGGATTTTATTACTTGAGAAAGAACGAAATCTCGCTCATTTTCTCAGTCTGGAACTCCAAAAAGAGCAATA
CCGTGTTGATCTGGTCGAGGAGGGGCAAAAAGCCCTCTCCATGGCTCTCCAGACAGATTATGACTTGATTTTACTGAATG
CTCGTCTGGGGGATATGACGGCCCAGGATTTTGCAGAGAGGCTGAGTCGGACAAAACCAGCCTCAGTGATCATGGTCTTG
GACCATCGCGAAGAATTGCAAGACCAGATTGAGACAATCCAGCGCTTCGCCGTTTCTTACATCTATAAGCCAGTGATTAT
TGATAATCTAGTAGCTCGTATTTCAGCGATTTTCCGAGGTCGGGACTTCATTGACCAACACTGTAGTCAAATGAAGGTTC
CAACGTCTTACCGCAACCTACGTATGGATGTAGAACATCATACCGTTTATCGTGGCGAGGAGATGATTGCTCTGACGCGT
CGTGAGTATGACCTTTTGGCCACTCTCATGGGAAGCAAGAAGGTCTTGACTCGTGAGCAGTTGTTGGAAAGTGTTTGGAA
GTACGAAAGTGCGACAGAAACCAATATCGTGGATGTTTATATCCGTTATCTACGTAGCAAGCTTGATGTAAAAGGTCAAA
AAAGCTACATTAAAACCGTGCGTGGTGTTGGTTACACCATGCAAGAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-226)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1X1GGK8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

49.13

100

0.493
  covR Lactococcus lactis subsp. lactis strain DGCC12653

46.93

99.563

0.467

Multiple sequence alignment