Detailed information NTG0115308

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: RG26_RS23800
• Genome accession: NZ_CP010119
• Coordinates: 4449396..4451672 (+)
• Length: 758 a.a.
• NCBI ID: WP_000934041.1
• Uniprot ID: P0ABI0
• Organism: Escherichia coli strain C3
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 4444396..4456672

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RG26_RS23780 (RG26_22440)	macA	4445367..4446482 (+)	1116	WP_000746460.1	macrolide transporter subunit MacA	-
RG26_RS23785 (RG26_22445)	macB	4446479..4448425 (+)	1947	WP_000188197.1	macrolide ABC transporter ATP-binding protein/permease MacB	-
RG26_RS23790 (RG26_22450)	cspD	4448498..4448722 (-)	225	WP_000410785.1	cold shock-like protein CspD	-
RG26_RS31030	yljB	4448872..4448946 (+)	75	WP_001406719.1	protein YljB	-
RG26_RS23795 (RG26_22455)	clpS	4449045..4449365 (+)	321	WP_000520781.1	ATP-dependent Clp protease adapter ClpS	-
RG26_RS23800 (RG26_22460)	clpC	4449396..4451672 (+)	2277	WP_000934041.1	ATP-dependent Clp protease ATP-binding subunit ClpA	Regulator
RG26_RS23815 (RG26_22470)	infA	4452357..4452575 (-)	219	WP_001040187.1	translation initiation factor IF-1	-
RG26_RS23825 (RG26_22475)	aat	4452860..4453564 (-)	705	WP_001241678.1	leucyl/phenylalanyl-tRNA--protein transferase	-
RG26_RS23830 (RG26_22480)	cydC	4453606..4455327 (-)	1722	WP_001202188.1	cysteine/glutathione ABC transporter ATP-binding protein/permease CydC	-

Sequence

Protein

• Length: 758 a.a.
• Molecular weight: 84206.93 Da
• Isoelectric Point: 6.2512

>NTDB_id=115308 RG26_RS23800 WP_000934041.1 4449396..4451672(+) (clpC) [Escherichia coli strain C3]
MLNQELELSLNMAFARAREHRHEFMTVEHLLLALLSNPSAREALEACSVDLVALRQELEAFIEQTTPVLPASEEERDTQP
TLSFQRVLQRAVFHVQSSGRNEVTGANVLVAIFSEQESQAAYLLRKHEVSRLDVVNFISHGTRKDEPTQSSDPGSQPNSE
EQAGGEERMENFTTNLNQLARVGGIDPLIGREKELERAIQVLCRRRKNNPLLVGESGVGKTAIAEGLAWRIVQGDVPEVM
ADCTIYSLDIGSLLAGTKYRGDFEKRFKALLKQLEQDTNSILFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKIRVIG
STTYQEFSNIFEKDRALARRFQKIDITEPSIEETVQIINGLKPKYEAHHDVRYTAKAVRAAVELAVKYINDRHLPDKAID
VIDEAGARARLMPVSKRKKTVNVADIESVVARIARIPEKSVSQSDRDTLKNLGDRLKMLVFGQDKAIEALTEAIKMARAG
LGHEHKPVGSFLFAGPTGVGKTEVTVQLSKALGIELLRFDMSEYMERHTVSRLIGAPPGYVGFDQGGLLTDAVIKHPHAV
LLLDEIEKAHPDVFNILLQVMDNGTLTDNNGRKADFRNVVLVMTTNAGVRETERKSIGLIHQDNSTDAMEEIKKIFTPEF
RNRLDNIIWFDHLSTDVIHQVVDKFIVELQVQLDQKGVSLEVSQEARNWLAEKGYDRAMGARPMARVIQDNLKKPLANEL
LFGSLVDGGQVTVALDKEKNELTYGFQSAQKHKAEAAH

Nucleotide

• Length: 2277 bp

>NTDB_id=115308 RG26_RS23800 WP_000934041.1 4449396..4451672(+) (clpC) [Escherichia coli strain C3]
ATGCTCAATCAAGAACTGGAACTCAGTTTAAATATGGCTTTCGCCAGAGCGCGCGAGCACCGTCATGAGTTTATGACCGT
CGAGCACTTGTTACTGGCGCTGCTCAGTAACCCATCTGCCCGGGAGGCGCTGGAAGCGTGTTCTGTGGATTTGGTTGCGC
TCCGTCAGGAACTGGAAGCCTTTATTGAACAAACCACACCCGTTCTGCCTGCCAGTGAAGAGGAGCGCGACACACAGCCG
ACGCTGAGTTTTCAGCGTGTACTGCAACGTGCGGTCTTCCATGTCCAATCCTCCGGTCGCAATGAGGTAACCGGTGCAAA
CGTTCTGGTCGCTATCTTTAGCGAACAGGAGTCGCAGGCGGCATATCTGTTGCGTAAACATGAAGTCAGCCGTCTCGATG
TGGTGAACTTTATCTCTCATGGCACGCGTAAAGACGAGCCGACACAGTCTTCTGATCCTGGCAGCCAGCCAAACAGCGAA
GAACAAGCTGGTGGGGAGGAACGTATGGAGAATTTCACGACGAACCTGAATCAGCTTGCGCGCGTGGGCGGAATCGACCC
ACTGATTGGTCGTGAGAAGGAGCTGGAGCGTGCTATTCAGGTTCTCTGCCGTCGCCGTAAAAACAACCCGCTGCTGGTGG
GGGAATCTGGTGTCGGTAAAACCGCGATTGCGGAAGGTCTTGCCTGGCGAATTGTTCAGGGCGATGTGCCGGAAGTGATG
GCTGACTGTACGATTTACTCTCTCGATATCGGTTCTCTGTTAGCGGGCACTAAATATCGCGGCGACTTTGAAAAACGTTT
TAAAGCGTTGCTCAAGCAGCTGGAGCAGGACACTAACAGCATCCTGTTTATTGATGAGATCCACACCATTATCGGTGCGG
GGGCAGCGTCTGGTGGCCAGGTCGATGCGGCTAACCTGATCAAACCGTTGCTCTCCAGCGGTAAAATTCGCGTAATTGGT
TCGACAACCTATCAGGAGTTCAGCAACATTTTCGAGAAAGACCGTGCTCTGGCGCGTCGCTTCCAGAAAATTGATATTAC
TGAACCGTCGATCGAAGAAACTGTTCAAATCATCAATGGCCTGAAACCGAAGTATGAAGCGCACCACGACGTGCGTTATA
CCGCAAAAGCGGTGCGTGCAGCGGTAGAGCTGGCGGTGAAATACATTAACGATCGTCATCTGCCGGATAAAGCCATTGAC
GTTATCGACGAAGCGGGCGCTCGCGCACGCCTGATGCCGGTAAGCAAACGCAAGAAAACCGTTAATGTGGCGGATATTGA
GTCCGTGGTGGCCCGTATTGCGCGCATTCCAGAGAAGAGTGTTTCTCAGAGTGACCGCGATACCCTGAAAAACCTCGGCG
ATCGCCTGAAAATGCTGGTCTTCGGTCAGGATAAAGCCATTGAGGCGCTGACTGAAGCCATTAAGATGGCGCGTGCAGGT
TTAGGTCACGAACATAAACCGGTTGGTTCGTTCCTGTTTGCCGGCCCTACCGGGGTCGGGAAAACAGAGGTGACGGTACA
GCTTTCGAAAGCGTTGGGCATTGAGCTGCTGCGCTTTGATATGTCCGAGTATATGGAACGCCATACCGTCAGCCGTCTGA
TTGGTGCGCCTCCGGGATACGTTGGTTTTGATCAGGGAGGTTTGCTGACTGATGCGGTCATCAAGCATCCACATGCGGTG
CTGTTGCTGGACGAAATCGAGAAAGCGCATCCGGACGTGTTCAATATTCTGTTGCAGGTGATGGACAACGGTACGCTGAC
CGATAACAACGGACGCAAAGCGGACTTCCGTAACGTGGTGCTGGTGATGACCACCAACGCCGGGGTACGTGAAACTGAGC
GTAAATCCATTGGTCTTATCCACCAGGATAACAGCACCGATGCGATGGAGGAGATCAAGAAGATCTTTACACCGGAATTC
CGTAACCGTCTCGACAACATTATCTGGTTTGATCATCTGTCAACCGACGTGATCCATCAGGTGGTGGATAAATTCATCGT
CGAGTTGCAGGTTCAGCTGGATCAGAAAGGTGTTTCTCTGGAAGTGAGCCAGGAAGCGCGTAACTGGCTGGCCGAGAAAG
GTTACGACCGGGCAATGGGCGCACGTCCGATGGCGCGTGTCATCCAGGACAACCTGAAAAAACCGCTCGCCAACGAACTG
CTGTTTGGTTCGCTGGTGGACGGCGGTCAGGTCACCGTCGCGCTGGATAAAGAGAAAAATGAGCTGACTTACGGATTCCA
GAGTGCACAAAAGCACAAGGCGGAAGCAGCGCATTAA

Domains

Predicted by InterProScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (486-647)

• ATPase family associated with various cellular activities (AAA) (AAA) (211-342)

• AAA lid domain (AAA_lid_9) (350-452)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (13-62)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (653-733)

3D structure

• AlphaFold DB: P0ABI0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	38.868	100	0.408
clpA	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	41.346	96.042	0.397
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	35.46	100	0.381
clpC	Streptococcus thermophilus LMD-9	42.37	89.05	0.377
clpC	Streptococcus thermophilus LMG 18311	42.222	89.05	0.376
clpC	Streptococcus mutans UA159	39.407	93.404	0.368