Detailed information NTG1151911

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MD993_RS08970
• Genome accession: NZ_OV648025
• Coordinates: 1896782..1897825 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus argenteus isolate 20S00001-1_long
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1891782..1902825

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MD993_RS08940	-	1892193..1893440 (-)	1248	WP_000656301.1	aminopeptidase	-
MD993_RS08945	-	1893452..1893652 (-)	201	WP_000180459.1	DUF1128 family protein	-
MD993_RS08950	-	1893799..1894263 (+)	465	WP_000228669.1	low molecular weight protein-tyrosine-phosphatase	-
MD993_RS08955	-	1894270..1894545 (+)	276	WP_000428174.1	YtxH domain-containing protein	-
MD993_RS08960	-	1894824..1896047 (+)	1224	WP_000037065.1	YihY/virulence factor BrkB family protein	-
MD993_RS08965	vraR	1896163..1896792 (-)	630	WP_000153529.1	two-component system response regulator VraR	Regulator
MD993_RS08970	vraS	1896782..1897825 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
MD993_RS08975	liaF	1897822..1898523 (-)	702	WP_031788217.1	cell wall-active antibiotics response protein LiaF	-
MD993_RS08980	-	1898538..1898924 (-)	387	WP_001110170.1	hypothetical protein	-
MD993_RS08985	map	1899145..1899903 (-)	759	WP_031788218.1	type I methionyl aminopeptidase	-
MD993_RS08990	-	1900434..1901420 (+)	987	WP_031788370.1	aromatic acid exporter family protein	-
MD993_RS08995	-	1902052..1902774 (-)	723	WP_031787877.1	type 1 glutamine amidotransferase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=1151911 MD993_RS08970 WP_001017131.1 1896782..1897825(-) (vraS) [Staphylococcus argenteus isolate 20S00001-1_long]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=1151911 MD993_RS08970 WP_001017131.1 1896782..1897825(-) (vraS) [Staphylococcus argenteus isolate 20S00001-1_long]
ATGAACCATTATATTAGAACAATTGGTTCGATGCTCATCTTAGTATACAGCATGCTAGCGGCATTTCTTTTTATAGATAA
AGTTTTCGTTAATATTATTTATTTTCAAGGCATGTTTTATACACAAATATTTGGGATTCCAGTCTTTTTATTTTTAAATC
TCATTATCATTTTATTGTGTATCATCGTCGGATCGGTGCTTGCCTACAAAATTAATCAACAAAATGATTGGATTAAGACA
CAAATTGAGCGTTCTATGGAAGGCGAAACAGTAGGTATCAATGATCAAAATATAGAAATATATAGTGAAACATTAGATTT
ATATCATACGTTAGTACCTTTAAATCAAGAATTGCATAAGTTAAGACTCAAAACGCAAAATTTAACAAATGAAAATTACA
ATATTAATGATGTTAAAGTTAAAAAGATTATCGAAGATGAAAGACAACGTTTAGCTAGAGAACTACACGACTCTGTTAGT
CAACAACTTTTTGCGGCAAGTATGATGTTATCTGCAATTAAAGAAACGAAATTAGAACCACCTTTAGATCAACAAATACC
TATTTTAGAGAAAATGGTTCAAGATTCTCAGTTAGAAATGCGTGCTTTGCTGCTACACTTAAGACCACTCGGCTTGAAAG
ATAAGTCATTAGGCGAAGGTATTAAAGATTTAGTTATTGATTTACAAAAGAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCAAAAGGTATTGAAGATCATTTATTTAGAATTACGCAAGAAGCAATATCTAATACATTGAGACA
TTCAAATGGTACGAAAGTAACTGTAGAATTATTTAATAAAGATGATTATTTATTGTTAAGGATACAAGATAATGGTAAAG
GTTTTAATGTAGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCACTACCAGATTCAGGTACACGTATTGAGGTGAAAGCACCTCTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1