Detailed information NTG1146045

Bioinformatically predicted

Overview

• Name: comEC
• Type: Machinery gene
• Locus tag: EDCC5055_RS08105
• Genome accession: NZ_LT671859
• Coordinates: 1610944..1613145 (-)
• Length: 733 a.a.
• NCBI ID: WP_001566051.1
• Uniprot ID: A0A266CU80
• Organism: Staphylococcus aureus isolate Clinical isolate
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1605944..1618145

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EDCC5055_RS08090 (EDCC5055_01506)	lepA	1607448..1609271 (-)	1824	WP_000368341.1	translation elongation factor 4	-
EDCC5055_RS08095 (EDCC5055_01507)	rpsT	1609617..1609868 (+)	252	WP_001274017.1	30S ribosomal protein S20	-
EDCC5055_RS08100 (EDCC5055_01508)	holA	1609913..1610887 (-)	975	WP_001282562.1	DNA polymerase III subunit delta	-
EDCC5055_RS08105 (EDCC5055_01509)	comEC	1610944..1613145 (-)	2202	WP_001566051.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
EDCC5055_RS08110 (EDCC5055_01510)	-	1613150..1613611 (-)	462	WP_000439693.1	ComE operon protein 2	-
EDCC5055_RS08115 (EDCC5055_01511)	comEA	1613703..1614389 (-)	687	WP_001792568.1	ComEA family DNA-binding protein	Machinery gene
EDCC5055_RS08120 (EDCC5055_01512)	-	1614429..1615145 (-)	717	WP_000084829.1	class I SAM-dependent DNA methyltransferase	-
EDCC5055_RS08125 (EDCC5055_01513)	rsfS	1615148..1615501 (-)	354	WP_001088022.1	ribosome silencing factor	-
EDCC5055_RS08130 (EDCC5055_01514)	yqeK	1615502..1616086 (-)	585	WP_001019324.1	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK	-
EDCC5055_RS08135 (EDCC5055_01515)	nadD	1616076..1616645 (-)	570	WP_015581862.1	nicotinate (nicotinamide) nucleotide adenylyltransferase	-
EDCC5055_RS08140 (EDCC5055_01516)	yhbY	1616648..1616938 (-)	291	WP_000955231.1	ribosome assembly RNA-binding protein YhbY	-
EDCC5055_RS08145 (EDCC5055_01517)	aroE	1616942..1617748 (-)	807	WP_000666761.1	shikimate dehydrogenase	-

Sequence

Protein

• Length: 733 a.a.
• Molecular weight: 84839.89 Da
• Isoelectric Point: 10.0277

>NTDB_id=1146045 EDCC5055_RS08105 WP_001566051.1 1610944..1613145(-) (comEC) [Staphylococcus aureus isolate Clinical isolate]
MLFVALSMIVGVLWNSSKVLSTFLFILLLYITYRKNKIVYAPISLFLIIFSAWYLHYSQQAIFNYINYIERNSQFNERAQ
VIQIQRQGSDTYKGRLSLKNEIYPFFLTDKKNFDLKKIESRNCIVKGQFKVNDNKFVTLKLQSIVVQSCLESNRSNLIEK
HKQFIMNRIYDSGIKFPDRIMALITGDVKEVNEQFKERVKEIGIYHLLAVSGSHIAAIVFLIYQPLKRLNLPLFVIKGIT
IIVLALFAQYTNYAPSAVRAIIMTTLVLVITKQIKIKSIQLLAFAFIIMFILNPLVVYDIGFQFSFIISFFIMLLFPFLQ
QLSKLQSLFIITFIAQLASFIVAIPSFHQLQWVGFLSNLIFVPYYSIILFPLSILFFITSHFIVGLTPLNYLVDLSFNFH
DWLLDLFTRIKQSHFSVPKFNDWIFIVFIISVYYIFWLLAKRKYILVTFWTIIILTLLITFPTNSHHKITMLNVGQGDSI
LYEGGKNQNVLIDTGGKVIDDTKQPSYSISKYHILPTLNERGINELEYLILTHPHNDHIGEVEYIISHIKIKHIVIYNKG
YSSNTLMLLSKLSHKYNIKLMDVRQVSSFKLGDSSFLFFDSFIPNSRDKNEYSIITMITYQNKKVLLMGDASKNNESLLL
KKYNLPEIDILKVGHHGSKTSSSKEFIEMIKPKISLISSGKNNMYHLPNIEVVKRLQRIRSRIYNSQQNGQVTIDLDDNL
KVDSSSYGNASGL

Nucleotide

• Length: 2202 bp

>NTDB_id=1146045 EDCC5055_RS08105 WP_001566051.1 1610944..1613145(-) (comEC) [Staphylococcus aureus isolate Clinical isolate]
TTGCTGTTTGTCGCGTTATCAATGATTGTAGGAGTGCTTTGGAATTCTAGCAAAGTGCTCTCTACATTTCTTTTCATTTT
ACTTTTGTATATTACTTATCGTAAAAATAAAATCGTTTATGCCCCTATTTCTCTCTTTTTAATCATTTTCTCCGCATGGT
ATTTACATTATTCACAACAAGCAATATTTAATTATATCAATTATATTGAACGTAATTCTCAGTTTAATGAGCGTGCTCAA
GTAATCCAAATTCAACGTCAAGGTAGTGACACATATAAAGGTAGGTTGAGTTTAAAAAATGAAATATATCCTTTCTTTTT
AACAGATAAAAAGAATTTTGATTTAAAGAAAATTGAAAGTCGTAATTGTATTGTTAAAGGACAATTCAAAGTTAATGACA
ATAAGTTTGTAACTCTTAAATTACAAAGTATAGTTGTACAAAGCTGCCTAGAATCGAACCGGTCTAATTTAATTGAGAAA
CATAAACAGTTTATAATGAATCGAATTTATGATTCGGGTATTAAGTTTCCGGATCGTATTATGGCATTGATTACTGGTGA
CGTAAAAGAAGTTAATGAGCAATTTAAGGAACGTGTTAAAGAGATAGGTATATATCATTTGCTGGCAGTTAGTGGCTCGC
ATATAGCTGCAATTGTATTTTTAATTTACCAACCTTTAAAACGATTAAATTTACCTTTATTTGTCATTAAAGGAATTACA
ATCATTGTATTAGCTTTATTTGCTCAATACACAAATTATGCACCTAGTGCTGTAAGAGCTATAATAATGACAACTCTTGT
ACTGGTTATTACTAAGCAAATTAAAATAAAGAGTATTCAGCTATTAGCATTTGCATTTATAATTATGTTTATTTTAAATC
CACTAGTTGTTTATGATATTGGATTTCAATTTTCATTCATCATTTCATTTTTTATTATGCTACTTTTTCCTTTTTTACAG
CAATTGTCAAAGTTACAATCATTATTCATAATTACGTTTATTGCACAATTAGCTTCATTTATCGTTGCCATTCCAAGCTT
TCATCAACTTCAATGGGTGGGATTTTTATCTAATTTGATTTTTGTACCGTACTATTCGATTATATTGTTTCCGCTATCTA
TTTTATTCTTTATTACAAGTCATTTTATTGTGGGATTAACGCCGCTAAATTACTTGGTTGACCTAAGTTTTAATTTTCAT
GACTGGTTACTAGACCTATTCACAAGAATCAAGCAATCACATTTTTCTGTTCCCAAGTTTAATGATTGGATATTTATAGT
ATTTATAATTTCTGTTTATTACATATTTTGGTTATTGGCTAAACGTAAATATATATTGGTTACGTTTTGGACTATAATTA
TTCTGACATTATTAATAACGTTTCCAACAAATTCACATCACAAAATTACAATGTTAAATGTGGGGCAGGGAGACAGTATT
TTATATGAAGGCGGTAAGAACCAAAATGTCTTGATTGATACAGGTGGGAAAGTGATTGATGATACTAAACAACCTAGTTA
TTCAATTTCTAAATATCATATTTTACCAACGCTAAATGAAAGAGGGATAAATGAATTAGAGTATCTAATTTTAACACATC
CACACAATGACCATATTGGTGAAGTGGAATATATTATTAGTCATATTAAAATTAAACATATAGTGATATACAATAAGGGA
TATAGTAGTAATACATTGATGTTATTATCGAAATTAAGCCATAAGTACAACATTAAACTTATGGATGTAAGACAAGTTAG
TAGTTTTAAACTTGGAGATAGTAGTTTTCTATTTTTTGATAGTTTTATTCCAAATAGCCGAGATAAAAATGAGTATTCGA
TTATTACTATGATTACATATCAAAATAAAAAAGTTTTATTAATGGGCGATGCTAGTAAAAATAATGAATCTTTACTACTA
AAAAAATATAACTTGCCGGAGATTGATATTTTAAAAGTAGGACATCATGGGAGCAAGACAAGTAGTTCTAAAGAATTTAT
AGAGATGATTAAGCCTAAAATAAGTTTGATTTCTTCTGGGAAGAACAATATGTATCATCTTCCTAATATAGAAGTTGTTA
AACGATTGCAAAGGATTCGCAGTCGCATTTACAATAGTCAACAAAACGGTCAAGTTACAATTGACTTAGATGATAATTTA
AAAGTTGATTCAAGCTCTTATGGAAATGCAAGTGGTTTATAG

Domains

Predicted by InterproScan.

• Metallo-beta-lactamase superfamily (Lactamase_B) (474-679)

• Competence protein (Competence) (183-441)

3D structure

• AlphaFold DB: A0A266CU80

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC	Staphylococcus aureus N315	98.499	100	0.985
comEC	Staphylococcus aureus MW2	98.09	100	0.981