Detailed information NTG1142951

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: DQL00_RS04250
• Genome accession: NZ_LS483523
• Coordinates: 787143..788180 (+)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain 4041STDY6836169
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 782143..793180

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL00_RS04210	yidC	782177..783103 (-)	927	WP_000835944.1	membrane protein insertase YidC	-
DQL00_RS04215	-	783181..783459 (-)	279	WP_001174613.1	acylphosphatase	-
DQL00_RS04220	-	783493..784233 (+)	741	WP_000152674.1	TrmH family RNA methyltransferase	-
DQL00_RS04225	-	784289..784972 (+)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
DQL00_RS04235	asnA	785085..786077 (+)	993	WP_000747993.1	aspartate--ammonia ligase	-
DQL00_RS04240	rsmD	786142..786681 (+)	540	WP_000691938.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
DQL00_RS04245	coaD	786671..787159 (+)	489	WP_001280746.1	pantetheine-phosphate adenylyltransferase	-
DQL00_RS04250	sepM	787143..788180 (+)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
DQL00_RS04255	-	788238..788468 (+)	231	WP_000250391.1	DUF1146 family protein	-
DQL00_RS04260	murA	788492..789775 (+)	1284	WP_023396463.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
DQL00_RS04265	-	789768..789956 (+)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
DQL00_RS04270	endA	789995..790819 (+)	825	WP_023396715.1	DNA-entry nuclease EndA	Machinery gene
DQL00_RS04275	-	791110..792441 (+)	1332	WP_000390042.1	hemolysin family protein	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=1142951 DQL00_RS04250 WP_000727277.1 787143..788180(+) (sepM) [Streptococcus pneumoniae strain 4041STDY6836169]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=1142951 DQL00_RS04250 WP_000727277.1 787143..788180(+) (sepM) [Streptococcus pneumoniae strain 4041STDY6836169]
ATGAAAAAAAAGATTAGATGGCCCTTGTATGTCATTGCGGCCTTGATTGTGACCTTCTTGGCATTTGTGGTGCCTTTGCC
CTACTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCTACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGACTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGAAAAAATGGGATTGGAATCGGCTTGATTGATCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGCCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591