Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   DQM95_RS06855 Genome accession   NZ_LS483397
Coordinates   1322463..1324733 (+) Length   756 a.a.
NCBI ID   WP_046391474.1    Uniprot ID   -
Organism   Streptococcus uberis strain NCTC3858     
Function   repress competence development (at the early growth phase) (predicted from homology)   
Competence regulation

Genomic Context

Location: 1317463..1329733
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM95_RS06825 (NCTC3858_01393) - 1317798..1318013 (-) 216 WP_012658749.1 exodeoxyribonuclease VII small subunit -
  DQM95_RS06830 (NCTC3858_01394) xseA 1318003..1319331 (-) 1329 WP_012658750.1 exodeoxyribonuclease VII large subunit -
  DQM95_RS06835 (NCTC3858_01395) - 1319473..1320327 (-) 855 WP_037591785.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  DQM95_RS06840 (NCTC3858_01396) - 1320431..1321165 (-) 735 WP_012658752.1 amino acid ABC transporter ATP-binding protein -
  DQM95_RS06845 (NCTC3858_01397) - 1321162..1321851 (-) 690 WP_012658753.1 amino acid ABC transporter permease -
  DQM95_RS06850 (NCTC3858_01398) - 1321978..1322208 (-) 231 WP_012658754.1 DUF1797 family protein -
  DQM95_RS06855 (NCTC3858_01399) clpE 1322463..1324733 (+) 2271 WP_046391474.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  DQM95_RS06860 (NCTC3858_01400) - 1324867..1325322 (+) 456 WP_037591783.1 NUDIX hydrolase -
  DQM95_RS06865 (NCTC3858_01401) - 1325374..1325685 (+) 312 WP_037591782.1 DUF1827 family protein -
  DQM95_RS06870 (NCTC3858_01402) ileS 1325788..1328583 (-) 2796 WP_037591781.1 isoleucine--tRNA ligase -
  DQM95_RS06875 - 1328836..1329600 (-) 765 WP_037591780.1 DivIVA domain-containing protein -

Sequence

Protein


Download         Length: 756 a.a.        Molecular weight: 84173.44 Da        Isoelectric Point: 5.1596

>NTDB_id=1140172 DQM95_RS06855 WP_046391474.1 1322463..1324733(+) (clpE) [Streptococcus uberis strain NCTC3858]
MLCQNCKLNEATIHLYTNVNGKQRQVDLCQNCYQIMKTDTNNPILGGQNGKPQQDSINPFFDDFFGDLNNFRAFGQLPNT
PPTQSGGGQGNGGHRGGYNGSQAQAAQTQKPNGLLEEFGINVTDIARRGDIDPVIGRDDEIVRVIEILNRRTKNNPVLIG
EPGVGKTAVVEGLAQKIVDGDVPHKLQHKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRNRQDVILFIDEIHEIVGAG
SAGDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVEETITILKGIQSKYEDYHHVKYSQ
DAIEAAAHLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKEIDKRLVEAENLKAQATRDEDFERAAYFRDQIAKYK
ELQKQKVDDEDTPIITEKTIEAIVEQKTNIPVGDLKEKEQSQLVNLSDDLKAHVIGQDDAVEKIAKAIRRNRVGLGSPNR
PIGSFLFVGPTGVGKTELSKQLAIELFGSADNMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEKVRRNPYSLILL
DEVEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGRVEASVGFGAAREGRTNSVLGELSNYFSPEFMN
RFDGIIEFQPLSKENLLHIVDLMLEDVNARLSHNNIHLEVTAKVKEKLVDLGYDPKMGARPLRRTIQEHIEDAITDFYLE
NPTEKNLKAMMSSNGNILIKAIKAKSSEELLDMPVK

Nucleotide


Download         Length: 2271 bp        

>NTDB_id=1140172 DQM95_RS06855 WP_046391474.1 1322463..1324733(+) (clpE) [Streptococcus uberis strain NCTC3858]
ATGCTTTGTCAAAATTGTAAATTAAATGAAGCAACTATTCATCTATATACGAATGTGAATGGAAAACAAAGACAGGTAGA
TCTTTGTCAAAATTGTTATCAAATCATGAAAACAGATACTAATAATCCTATCCTAGGTGGTCAAAATGGGAAACCACAAC
AAGATTCGATAAATCCATTCTTTGATGACTTTTTTGGTGATCTCAACAATTTCAGGGCATTTGGTCAATTGCCTAACACG
CCACCAACTCAATCTGGAGGCGGACAAGGTAATGGGGGACACCGTGGAGGATACAACGGGTCCCAGGCTCAAGCTGCTCA
AACGCAAAAACCAAATGGCCTTTTAGAAGAATTCGGTATCAATGTAACTGATATTGCCAGAAGAGGTGATATTGATCCTG
TTATCGGACGCGATGATGAGATTGTTCGCGTCATTGAAATTCTAAATCGACGGACTAAAAATAACCCTGTCCTTATTGGG
GAACCTGGTGTTGGTAAAACTGCAGTTGTGGAGGGTTTAGCTCAAAAAATTGTAGATGGGGATGTTCCACATAAATTACA
ACACAAACAAGTCATTCGATTAGATGTAGTCAGTTTAGTTCAAGGAACTGGCATTCGTGGTCAGTTCGAAGAACGCATGC
AAAAACTAATGGAAGAAATCCGAAATCGCCAAGATGTCATTTTATTTATTGACGAAATTCATGAGATTGTCGGTGCTGGT
AGTGCAGGCGATGGCAATATGGATGCTGGTAACATTTTAAAACCTGCCCTTGCTCGTGGAGAATTACAACTGGTTGGTGC
AACGACGTTGAATGAATATCGGATCATTGAAAAAGATGCAGCACTCGAAAGACGTATGCAGCCAGTTAAAGTTGATGAAC
CTTCAGTTGAGGAAACCATCACTATTTTAAAAGGGATTCAAAGCAAATATGAAGATTACCATCATGTGAAATACAGTCAA
GATGCTATCGAAGCTGCTGCTCACCTTTCTAATAGGTATATTCAGGATCGTTTCCTTCCCGATAAAGCCATTGATTTGCT
CGACGAAGCCGGTTCTAAAATGAACTTGACATTAAACTTTGTTGATCCCAAAGAGATTGATAAGAGATTAGTCGAAGCTG
AAAACTTAAAAGCGCAAGCCACTAGGGATGAAGATTTTGAACGCGCAGCTTACTTCAGAGACCAAATTGCAAAATACAAA
GAATTGCAAAAACAAAAGGTAGACGACGAAGACACGCCTATTATCACAGAAAAAACAATTGAAGCCATTGTTGAACAAAA
AACCAATATTCCAGTTGGCGATTTAAAGGAAAAAGAACAATCCCAATTGGTCAACTTATCAGATGATCTTAAAGCGCATG
TCATCGGTCAAGATGATGCGGTTGAAAAGATTGCAAAAGCTATTCGACGTAATCGTGTCGGACTTGGTAGCCCTAATCGT
CCTATTGGTTCTTTCCTTTTCGTTGGACCGACTGGTGTTGGTAAAACAGAGCTTTCTAAGCAATTGGCTATTGAACTTTT
TGGATCTGCTGATAATATGATTCGATTTGACATGTCGGAATACATGGAAAAACATGCTGTTGCTAAATTGGTAGGAGCGC
CTCCAGGATATGTTGGTTATGAGGAAGCTGGTCAGCTGACAGAAAAAGTTAGACGGAACCCATACTCACTTATACTTCTG
GATGAAGTTGAGAAGGCTCATCCTGATGTGATGCATATGTTCTTACAAGTTTTGGATGATGGTCGCTTAACGGATGGACA
AGGTCGAACTGTGAGCTTTAAGGACACTATTATCATCATGACTTCAAATGCGGGAACAGGACGCGTTGAAGCTTCAGTTG
GTTTTGGTGCAGCGCGTGAAGGACGTACAAACTCTGTTTTAGGCGAATTAAGTAACTACTTTAGTCCAGAATTTATGAAC
CGTTTTGATGGTATCATTGAATTCCAACCATTAAGTAAAGAAAACTTACTCCACATTGTAGATTTAATGTTGGAAGATGT
TAATGCTCGCTTATCTCATAACAATATTCATCTTGAAGTAACAGCTAAGGTTAAAGAAAAATTGGTTGATCTTGGCTATG
ACCCTAAAATGGGGGCCCGTCCTCTAAGAAGGACCATTCAAGAGCATATCGAAGATGCTATTACAGATTTCTACTTAGAA
AATCCAACAGAAAAAAATCTCAAAGCTATGATGTCAAGTAATGGGAATATTCTTATTAAAGCCATTAAAGCGAAATCAAG
TGAAGAACTGCTTGATATGCCAGTTAAATAA

Domains

Predicted by InterproScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(651-726)

AAA lid domain (AAA_lid_9)

(295-392)

AAA domain (Cdc48 subfamily) (AAA_2)

(480-643)

ATPase family associated with various cellular activities (AAA) (AAA)

(157-276)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus mutans UA159

86.711

98.545

0.854
  clpE Streptococcus pneumoniae Rx1

83.511

99.471

0.831
  clpE Streptococcus pneumoniae D39

83.511

99.471

0.831
  clpE Streptococcus pneumoniae R6

83.511

99.471

0.831
  clpE Streptococcus pneumoniae TIGR4

83.378

99.471

0.829
  clpC Lactococcus lactis subsp. cremoris KW2

77.596

96.825

0.751
  clpC Bacillus subtilis subsp. subtilis str. 168

52.426

84.524

0.443
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

46.851

86.111

0.403
  clpC Streptococcus pneumoniae TIGR4

48.71

82.011

0.399
  clpC Streptococcus pneumoniae Rx1

48.71

82.011

0.399
  clpC Streptococcus pneumoniae D39

48.71

82.011

0.399
  clpC Streptococcus mutans UA159

47.981

81.878

0.393
  clpC Streptococcus thermophilus LMD-9

46.785

82.275

0.385
  clpC Streptococcus thermophilus LMG 18311

46.463

82.275

0.382

Multiple sequence alignment