Detailed information    

insolico Bioinformatically predicted

Overview

Name   comFA/cflA   Type   Machinery gene
Locus tag   DQM37_RS06435 Genome accession   NZ_LS483394
Coordinates   1259866..1261191 (-) Length   441 a.a.
NCBI ID   WP_111694913.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC10880     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1254866..1266191
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM37_RS06425 (NCTC10880_01284) hpf 1258601..1259149 (-) 549 WP_002988974.1 ribosome hibernation-promoting factor, HPF/YfiA family -
  DQM37_RS06430 (NCTC10880_01285) - 1259229..1259894 (-) 666 WP_111694912.1 ComF family protein -
  DQM37_RS06435 (NCTC10880_01286) comFA/cflA 1259866..1261191 (-) 1326 WP_111694913.1 DEAD/DEAH box helicase Machinery gene
  DQM37_RS06440 (NCTC10880_01287) - 1261247..1261879 (+) 633 WP_002988970.1 YigZ family protein -
  DQM37_RS06445 (NCTC10880_01288) cysK 1262007..1262948 (+) 942 WP_011888673.1 cysteine synthase A -
  DQM37_RS06450 (NCTC10880_01289) - 1262966..1263343 (-) 378 WP_002991882.1 S1 RNA-binding domain-containing protein -
  DQM37_RS06455 (NCTC10880_01290) - 1263343..1264743 (-) 1401 WP_111694914.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  DQM37_RS06460 (NCTC10880_01291) - 1264780..1265421 (-) 642 WP_002983671.1 response regulator transcription factor -

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 49799.28 Da        Isoelectric Point: 10.0182

>NTDB_id=1140104 DQM37_RS06435 WP_111694913.1 1259866..1261191(-) (comFA/cflA) [Streptococcus pyogenes strain NCTC10880]
MESIENSYGRLLLESQLPDSAKQLAQPLKSVVISRGKMICQRCHYQLDEEARLPNGAYYCRFCLVFGRNQSDKLLYAIPP
MHFPKGNYLVWSGQLTAYQEMISQQLLINMQNQKTTLVHAVTGAGKTEMIYAAIEAVINTGGWVCIASPRVDVCVEVATR
LSQAFSCSICLMHAESLPYQRAPIIVATTHQLLKFHKAFDLLIIDEVDAFPFVNNIQLHYAASQALKEGGAKILLTATST
RTLERKVNKGEVVKLTLARRFHNRPLVIPKFIRSFNLFKMIHRQKFPPKILKHLKKQRKTGYPLLIFLPTIIMAESVTAI
LKELLPAEQIACVSSQSQNRKEDITAFRQGKKTILITTTILERGVTFPQIDVFVLGSHHRVYSSQSLVQIAGRVGRSIDR
PDGTLYFFHEGISKAMLLAKKEIKEMNYKGYSHDLSTMSTN

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=1140104 DQM37_RS06435 WP_111694913.1 1259866..1261191(-) (comFA/cflA) [Streptococcus pyogenes strain NCTC10880]
ATGGAGTCTATTGAAAATAGTTATGGACGATTGTTGCTAGAAAGCCAGTTACCAGATTCAGCAAAGCAGCTTGCTCAACC
TTTAAAAAGTGTAGTAATATCGAGAGGAAAAATGATTTGTCAACGTTGTCACTATCAGCTTGATGAAGAAGCACGATTGC
CAAATGGAGCCTATTATTGCCGATTTTGTCTTGTCTTTGGACGAAATCAATCAGATAAATTGCTCTATGCTATCCCACCT
ATGCATTTTCCAAAAGGTAATTATCTGGTTTGGAGCGGTCAACTAACTGCTTATCAAGAGATGATTTCTCAACAATTATT
AATCAATATGCAAAATCAAAAAACAACATTAGTTCATGCTGTAACTGGTGCAGGAAAAACAGAAATGATTTATGCTGCGA
TTGAGGCGGTAATTAACACAGGTGGCTGGGTTTGCATTGCCAGCCCAAGAGTAGATGTTTGTGTAGAGGTGGCTACTCGT
TTATCCCAAGCCTTCTCCTGCAGCATCTGTTTAATGCACGCAGAGTCTCTTCCTTATCAAAGAGCTCCTATTATAGTAGC
CACAACGCATCAGCTGCTAAAATTTCACAAGGCTTTTGATCTCTTAATTATTGATGAAGTAGACGCATTCCCTTTTGTAA
ATAATATTCAACTTCATTATGCTGCAAGTCAGGCTTTAAAAGAAGGTGGCGCAAAGATTTTATTAACTGCAACTTCAACT
AGAACTTTAGAAAGAAAGGTAAACAAGGGAGAAGTAGTCAAGCTGACATTGGCGAGACGCTTTCATAACAGGCCATTAGT
TATTCCAAAATTTATAAGAAGTTTTAATCTATTTAAAATGATACATCGGCAAAAATTTCCTCCTAAAATTTTAAAACACT
TAAAAAAACAAAGAAAAACAGGCTATCCCCTTTTAATTTTTCTACCCACTATTATAATGGCAGAATCTGTTACAGCAATC
TTAAAAGAGTTATTGCCCGCCGAACAAATAGCTTGTGTTTCTAGTCAATCACAAAACAGGAAAGAAGATATCACAGCTTT
TCGTCAAGGGAAAAAAACGATTTTAATTACAACAACAATTTTAGAAAGGGGTGTGACATTTCCCCAAATTGATGTTTTTG
TTCTTGGGTCTCATCATCGTGTCTATAGTTCCCAAAGTCTTGTTCAAATTGCTGGACGAGTTGGAAGATCTATAGACAGA
CCAGACGGAACGTTATATTTCTTTCATGAAGGTATCAGTAAAGCAATGCTACTAGCAAAAAAAGAGATTAAAGAAATGAA
TTATAAAGGGTATTCGCATGATCTGTCTACTATGTCAACAAATTAG

Domains

Predicted by InterproScan.

Helicase conserved C-terminal domain (Helicase_C)

(289-396)

DEAD/DEAH box helicase (DEAD)

(98-244)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comFA/cflA Streptococcus pneumoniae Rx1

53.699

95.011

0.51
  comFA/cflA Streptococcus pneumoniae D39

53.699

95.011

0.51
  comFA/cflA Streptococcus pneumoniae R6

53.699

95.011

0.51
  comFA/cflA Streptococcus pneumoniae TIGR4

53.699

95.011

0.51
  comFA/cflA Streptococcus mitis NCTC 12261

52.37

95.692

0.501
  comFA/cflA Streptococcus mitis SK321

51.422

95.692

0.492
  comFA Lactococcus lactis subsp. cremoris KW2

47.619

90.476

0.431

Multiple sequence alignment