Detailed information NTG1139448

Bioinformatically predicted

Overview

• Name: vicK
• Type: Regulator
• Locus tag: DQM89_RS02330
• Genome accession: NZ_LS483382
• Coordinates: 429252..430604 (+)
• Length: 450 a.a.
• NCBI ID: WP_002995609.1
• Uniprot ID: A0A4U7GC27
• Organism: Streptococcus pyogenes strain NCTC13738
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 424252..435604

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM89_RS02305	-	424401..424550 (+)	150	WP_047235923.1	hypothetical protein	-
DQM89_RS02310 (NCTC13738_00454)	-	424945..426093 (+)	1149	WP_076634299.1	acetyl-CoA C-acyltransferase	-
DQM89_RS02315 (NCTC13738_00455)	-	426050..427297 (+)	1248	WP_076634300.1	AMP-binding protein	-
DQM89_RS02320 (NCTC13738_00456)	-	427353..428387 (+)	1035	WP_172452999.1	DUF3114 domain-containing protein	-
DQM89_RS02325 (NCTC13738_00457)	vicR	428549..429259 (+)	711	WP_002985645.1	response regulator YycF	Regulator
DQM89_RS02330 (NCTC13738_00458)	vicK	429252..430604 (+)	1353	WP_002995609.1	cell wall metabolism sensor histidine kinase VicK	Regulator
DQM89_RS02335 (NCTC13738_00459)	vicX	430608..431417 (+)	810	WP_002985641.1	MBL fold metallo-hydrolase	Regulator
DQM89_RS02340 (NCTC13738_00460)	rnc	431850..432542 (+)	693	WP_076634302.1	ribonuclease III	-

Sequence

Protein

• Length: 450 a.a.
• Molecular weight: 51391.82 Da
• Isoelectric Point: 5.4026

>NTDB_id=1139448 DQM89_RS02330 WP_002995609.1 429252..430604(+) (vicK) [Streptococcus pyogenes strain NCTC13738]
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRDLINGRYTDIIDEKADIELMELSDQLNDLSD
VFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPV
VTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTGTGKVYEIVRDYPITS
VWIEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDVD

Nucleotide

• Length: 1353 bp

>NTDB_id=1139448 DQM89_RS02330 WP_002995609.1 429252..430604(+) (vicK) [Streptococcus pyogenes strain NCTC13738]
ATGACTAGAGATATCATTGGAAACTTATCCACATTTGAATTAGCGATCCTTATCTTACTTGTTTTTGTTGCTTTTTACTT
TATCCATCTTGCGGTGCGTGATTACCGAAATGCACGTATTATTCGGATGATGAGCCATAAAATCCGAGACTTGATTAATG
GTCGCTATACTGATATAATCGACGAAAAAGCAGACATTGAGTTAATGGAGCTTTCAGACCAGTTAAATGACCTGTCAGAT
GTTTTTCGCTTGACGCATGAAAATCTTGCCCAAGAAAAAAATCGCTTGGCAAGTATTTTGGCTTATATGTCAGATGGTGT
ACTTGCTACAGACCGGTCTGGTAAAATCATCATGATTAACGAGACAGCTCGCAAGCAATTAAATTTAAGTAAAGAAGAGG
CACTAAAGAAAAACATTACAGATTTGTTAGAAGGTGATACTTCATATACTTACCGTGATTTGGTATCCAAAACACCAGTG
GTAACTGTTAATAGCCGAAATGATATGGGTGAGTTTGTCTCATTACGCTTGCGCTTTGCGTTGAATAGGAGAGAGAGTGG
TTTTATTTCGGGATTGGTTGTGGTGCTCCATGACACCACAGAACAAGAAAAAGAAGAACGTGAACGCCGTCTTTTTGTCT
CTAATGTAAGTCATGAATTAAGGACCCCTTTAACTTCGGTTAAATCCTACTTGGAGGCTCTTGATGAAGGTGCACTTAAA
GAAGATATTGCTCCAAGTTTCATAAAAGTTTCTCTTGATGAAACTAATCGGATGATGCGTATGATTTCAGATCTTTTAAA
CCTGTCTCGGATTGATAATCAAGTAACCCAATTAGCAGTAGAGATGACTAATTTTACTGCTTTTATAACTTCTATTTTAA
ACAGATTTGATTTGGTTAAAAATCAGCATACAGGTACAGGAAAAGTCTATGAAATTGTAAGAGATTACCCTATTACCTCT
GTCTGGATTGAAATTGATAATGATAAAATGACACAGGTTATCGAGAATATTTTGAACAATGCCATTAAGTATTCTCCAGA
TGGTGGAAAAATCACAGTTCGTATGAAAACAACAGATACCCAATTAATTATTTCCATTTCAGACCAAGGACTAGGTATCC
CTAAAACAGATTTGCCTCTTATTTTTGATCGGTTCTATCGTGTAGACAAGGCAAGAAGTCGTGCCCAAGGAGGGACCGGT
CTAGGCCTTGCCATTGCTAAAGAAATCATCAAGCAGCACCATGGCTTTATCTGGGCTAAGAGTGACTATGGTAAAGGATC
GACCTTTACTATTGTCTTGCCTTATGAAAAAGATGCAGCCATCTATGAAGAATGGGAGGAAGATGTAGACTAA

Domains

Predicted by InterproScan.

• PAS fold (PAS) (95-162)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (326-436)

• His Kinase A (phospho-acceptor) domain (HisKA) (209-273)

3D structure

• AlphaFold DB: A0A4U7GC27

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicK	Streptococcus mutans UA159	72.947	92	0.671
micB	Streptococcus pneumoniae Cp1015	67.765	94.444	0.64