Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpC   Type   Regulator
Locus tag   DQM47_RS09065 Genome accession   NZ_LS483360
Coordinates   1761399..1763843 (-) Length   814 a.a.
NCBI ID   WP_023610724.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC10876     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1758747..1796999 1761399..1763843 within 0


Gene organization within MGE regions


Location: 1758747..1796999
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM47_RS09055 (NCTC10876_01799) groL 1759264..1760895 (-) 1632 WP_002982320.1 chaperonin GroEL -
  DQM47_RS09060 (NCTC10876_01800) groES 1760931..1761221 (-) 291 WP_002991292.1 co-chaperone GroES -
  DQM47_RS09065 (NCTC10876_01801) clpC 1761399..1763843 (-) 2445 WP_023610724.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  DQM47_RS09070 (NCTC10876_01802) - 1763843..1764304 (-) 462 WP_023610213.1 CtsR family transcriptional regulator -
  DQM47_RS09075 - 1764500..1764703 (-) 204 WP_002991299.1 cold-shock protein -
  DQM47_RS09080 (NCTC10876_01804) - 1765293..1766363 (-) 1071 WP_063629765.1 tyrosine-type recombinase/integrase -
  DQM47_RS09085 (NCTC10876_01805) - 1766491..1766793 (-) 303 WP_111685849.1 hypothetical protein -
  DQM47_RS09090 (NCTC10876_01806) - 1766786..1767172 (-) 387 WP_063629763.1 ImmA/IrrE family metallo-endopeptidase -
  DQM47_RS09095 (NCTC10876_01807) - 1767176..1767526 (-) 351 WP_063629762.1 helix-turn-helix domain-containing protein -
  DQM47_RS09105 (NCTC10876_01808) - 1767923..1768132 (+) 210 WP_111685850.1 helix-turn-helix domain-containing protein -
  DQM47_RS09110 (NCTC10876_01809) - 1768132..1768494 (+) 363 WP_063629760.1 hypothetical protein -
  DQM47_RS09115 (NCTC10876_01810) - 1768516..1768800 (+) 285 WP_063629759.1 hypothetical protein -
  DQM47_RS09120 (NCTC10876_01811) - 1768827..1769045 (+) 219 WP_063629758.1 hypothetical protein -
  DQM47_RS09125 (NCTC10876_01812) dnaB 1769054..1770400 (+) 1347 WP_111685851.1 replicative DNA helicase -
  DQM47_RS09130 (NCTC10876_01813) - 1770387..1771133 (+) 747 WP_111685852.1 conserved phage C-terminal domain-containing protein -
  DQM47_RS09135 (NCTC10876_01814) - 1771134..1771955 (+) 822 WP_111685853.1 ATP-binding protein -
  DQM47_RS09140 (NCTC10876_01815) - 1771955..1772182 (+) 228 WP_063629755.1 hypothetical protein -
  DQM47_RS09935 (NCTC10876_01816) - 1772196..1772366 (+) 171 WP_168388561.1 hypothetical protein -
  DQM47_RS09145 (NCTC10876_01817) - 1772363..1772632 (+) 270 WP_109982045.1 hypothetical protein -
  DQM47_RS09150 (NCTC10876_01818) - 1772635..1773384 (+) 750 WP_111685854.1 DNA-methyltransferase -
  DQM47_RS09155 (NCTC10876_01819) - 1773432..1774178 (+) 747 WP_231907105.1 DUF1642 domain-containing protein -
  DQM47_RS09160 (NCTC10876_01820) - 1774190..1774408 (+) 219 WP_111685855.1 hypothetical protein -
  DQM47_RS09165 (NCTC10876_01821) ssbA 1774405..1774797 (+) 393 WP_032460876.1 single-stranded DNA-binding protein Machinery gene
  DQM47_RS09170 (NCTC10876_01822) - 1774811..1775089 (+) 279 WP_029713970.1 hypothetical protein -
  DQM47_RS09180 (NCTC10876_01824) - 1775184..1775411 (+) 228 WP_063629751.1 hypothetical protein -
  DQM47_RS09185 (NCTC10876_01825) - 1775383..1775847 (+) 465 WP_063629750.1 hypothetical protein -
  DQM47_RS09190 (NCTC10876_01826) - 1775957..1776499 (+) 543 WP_063629749.1 site-specific integrase -
  DQM47_RS09195 (NCTC10876_01827) - 1776636..1776851 (+) 216 WP_227877423.1 hypothetical protein -
  DQM47_RS10080 - 1777240..1777434 (+) 195 WP_227876734.1 HNH endonuclease -
  DQM47_RS09205 (NCTC10876_01828) - 1777552..1778037 (+) 486 WP_000601034.1 hypothetical protein -
  DQM47_RS09210 (NCTC10876_01829) - 1778030..1779742 (+) 1713 WP_111685857.1 terminase TerL endonuclease subunit -
  DQM47_RS09215 (NCTC10876_01830) - 1779751..1780893 (+) 1143 WP_111685858.1 phage portal protein -
  DQM47_RS09220 (NCTC10876_01831) - 1780944..1781486 (+) 543 WP_063629746.1 HK97 family phage prohead protease -
  DQM47_RS09225 (NCTC10876_01832) - 1781497..1782759 (+) 1263 WP_063629745.1 phage major capsid protein -
  DQM47_RS09230 (NCTC10876_01833) - 1782779..1783117 (+) 339 WP_032460894.1 hypothetical protein -
  DQM47_RS09235 (NCTC10876_01834) - 1783114..1783419 (+) 306 WP_032460893.1 head-tail adaptor protein -
  DQM47_RS09240 (NCTC10876_01835) - 1783419..1783766 (+) 348 WP_032460892.1 hypothetical protein -
  DQM47_RS09245 (NCTC10876_01836) - 1783753..1784097 (+) 345 WP_063629744.1 hypothetical protein -
  DQM47_RS09250 (NCTC10876_01837) - 1784112..1784783 (+) 672 WP_063629743.1 phage tail protein -
  DQM47_RS09255 (NCTC10876_01838) - 1784787..1785260 (+) 474 WP_063629742.1 hypothetical protein -
  DQM47_RS09265 (NCTC10876_01839) - 1785450..1788185 (+) 2736 WP_111685860.1 phage tail tape measure protein -
  DQM47_RS09270 (NCTC10876_01840) - 1788182..1788904 (+) 723 WP_063629740.1 hypothetical protein -
  DQM47_RS09275 (NCTC10876_01841) - 1788905..1790848 (+) 1944 WP_231907106.1 phage tail spike protein -
  DQM47_RS09280 (NCTC10876_01842) - 1790845..1791960 (+) 1116 WP_063629043.1 hyaluronoglucosaminidase -
  DQM47_RS09285 (NCTC10876_01843) - 1791975..1793756 (+) 1782 WP_111685861.1 gp58-like family protein -
  DQM47_RS09290 (NCTC10876_01844) - 1793765..1794193 (+) 429 WP_111685862.1 DUF1617 family protein -
  DQM47_RS09295 (NCTC10876_01845) - 1794196..1794834 (+) 639 WP_111685863.1 hypothetical protein -
  DQM47_RS09300 (NCTC10876_01846) - 1794844..1795116 (+) 273 WP_111685864.1 hypothetical protein -
  DQM47_RS09305 (NCTC10876_01847) - 1795113..1795340 (+) 228 WP_003058873.1 phage holin -
  DQM47_RS09310 (NCTC10876_01849) - 1795456..1796673 (+) 1218 WP_111685865.1 peptidoglycan amidohydrolase family protein -
  DQM47_RS10190 (NCTC10876_01850) prx 1796838..1796999 (+) 162 WP_309543630.1 hypothetical protein Regulator

Sequence

Protein


Download         Length: 814 a.a.        Molecular weight: 90670.44 Da        Isoelectric Point: 7.0704

>NTDB_id=1138486 DQM47_RS09065 WP_023610724.1 1761399..1763843(-) (clpC) [Streptococcus pyogenes strain NCTC10876]
MIMYSTKMQDIFRQAQFQAARFDSHCLETWHVLLAMVAVDNSLANMILSEYDAQVAIEEYEAAAILAMGKTPKEQLSRVD
FRPQSKTLTNLLAFAQAISQITRDQEVGSEHVLFAILLNPDIMASRLLEIAGYQIKDNGNGQPRLADLRKAIERHAGYSK
EMIKAIHELRKPKKTKTQGTFSDMMKPPSTAGELSDFTRDLTEMARQGLLESVIGRDQEVSRMIQVLSRKTKNNPVLVGD
AGVGKTALAYGLAQRIANGAIPYELKEMRVLELDMMSVVAGTRFRGDFEERMNQIIDDIEADGQIILFVDELHTIMGSGS
GIDSTLDAANILKPALSRGTLHMVGATTQEEYQKHIEKDAALSRRFAKILIEEPNTEDAYQILMGLKLSYETYHNVSISN
EAVKTAVKMAHRYLTSKNLPDSAIDLLDEASAAVQNMVKKSAPETLTPIDQALIKGDMKKVSRLLAKEAKGQMRKPTPVT
EDDILATLSKLSGIPLEKLTQADSKKYLNLEKELHKRVIGQDAAVTAISRAIRRNQSGIRTGKRPIGSFMFLGPTGVGKT
ELAKALAEVLFDDEAALIRFDMSEYMEKFAASRLNGAPPGYVGYDEGGELTQKVRNKPYSVLLFDEVEKAHPDIFNVLLQ
VLDDGILTDSRGRKVDFSNTIIIMTSNLGATALRDDKTVGFGVKGIHQDHQAMEKRILEELRKTYRPEFINRIDEKVVFH
SLTQDNMRDVVKIMVQPLITTLAEKGITLKIQPLALKHLSEVGYDEHMGARPLRRTLQTEIEDKLSELILSRELTSGHTL
KIGLSHGKLTFHIA

Nucleotide


Download         Length: 2445 bp        

>NTDB_id=1138486 DQM47_RS09065 WP_023610724.1 1761399..1763843(-) (clpC) [Streptococcus pyogenes strain NCTC10876]
ATGATTATGTATTCAACGAAGATGCAAGACATTTTTAGACAGGCGCAGTTCCAAGCTGCTCGCTTTGATAGCCATTGCCT
GGAAACTTGGCATGTTTTGTTAGCTATGGTAGCTGTAGATAATTCTTTAGCAAATATGATTTTAAGTGAATATGATGCCC
AAGTCGCCATAGAAGAATATGAAGCTGCAGCTATTTTAGCCATGGGCAAAACCCCTAAGGAACAGTTGTCTCGTGTAGAC
TTCAGACCTCAATCTAAAACCTTGACTAACTTGTTAGCTTTTGCGCAGGCTATTAGCCAAATCACTAGGGATCAAGAAGT
CGGCTCTGAGCATGTCTTATTTGCTATTTTATTGAATCCAGATATCATGGCGAGTCGTTTGTTAGAAATAGCAGGCTATC
AGATAAAAGATAACGGCAATGGGCAGCCGCGATTAGCTGACTTGCGAAAAGCAATAGAACGTCATGCAGGTTACAGTAAG
GAAATGATTAAGGCTATTCACGAACTACGTAAGCCTAAAAAAACGAAAACACAAGGGACCTTTTCAGATATGATGAAGCC
ACCAAGTACAGCTGGTGAATTGAGTGATTTCACAAGAGATTTGACTGAAATGGCAAGACAAGGTTTGTTAGAATCGGTGA
TTGGACGTGACCAAGAAGTATCTCGTATGATTCAGGTACTAAGTCGTAAAACGAAAAACAATCCTGTCTTGGTAGGTGAT
GCAGGTGTTGGTAAAACTGCGCTTGCTTATGGCCTTGCTCAACGGATTGCAAATGGCGCTATTCCTTATGAACTTAAGGA
GATGCGTGTCCTAGAATTAGACATGATGAGTGTGGTAGCAGGAACCCGTTTTCGTGGGGATTTTGAAGAGCGCATGAATC
AAATCATTGATGATATTGAAGCTGATGGTCAGATTATTCTTTTTGTTGATGAACTACATACTATTATGGGTTCTGGCAGT
GGTATTGACAGTACACTTGATGCGGCTAACATTTTAAAACCAGCATTATCGCGCGGCACTCTTCATATGGTTGGAGCAAC
AACTCAAGAAGAATATCAAAAACATATTGAAAAAGATGCAGCTCTTTCGCGTCGTTTTGCTAAAATATTAATTGAAGAAC
CTAATACAGAAGATGCTTATCAGATTTTGATGGGCCTAAAATTATCTTATGAGACCTACCATAATGTCTCGATATCAAAT
GAGGCAGTTAAAACAGCTGTAAAAATGGCACACCGTTATTTAACCAGTAAAAATCTCCCTGATTCAGCTATCGATTTATT
AGATGAAGCTAGTGCTGCTGTGCAAAACATGGTGAAAAAATCAGCACCTGAGACTTTAACACCAATAGACCAAGCTCTTA
TCAAAGGTGATATGAAAAAAGTATCTCGCCTCTTAGCTAAAGAAGCAAAAGGTCAGATGAGAAAACCAACACCAGTGACA
GAAGATGATATTTTGGCAACCTTGAGTAAGTTATCGGGAATTCCACTTGAAAAACTGACGCAAGCTGATAGTAAAAAATA
CCTCAATTTAGAAAAAGAACTGCATAAGCGTGTGATTGGTCAGGATGCTGCTGTTACGGCTATTTCAAGAGCCATTCGTC
GCAATCAGTCAGGTATTCGAACAGGAAAACGTCCTATTGGATCATTTATGTTTCTTGGCCCAACAGGAGTAGGTAAGACA
GAACTAGCAAAGGCCCTTGCAGAAGTTCTCTTTGATGATGAAGCAGCGCTTATTCGTTTTGATATGTCTGAGTACATGGA
AAAATTCGCAGCGTCTAGGCTTAATGGAGCACCTCCTGGTTATGTCGGCTATGATGAAGGAGGTGAACTGACACAGAAAG
TTAGAAATAAACCTTATTCAGTCTTGCTTTTTGATGAAGTGGAAAAAGCACATCCTGATATTTTTAACGTTCTCCTTCAA
GTATTAGATGATGGTATATTGACTGATAGTCGTGGGCGTAAGGTCGATTTTTCAAATACTATTATTATCATGACCAGCAA
TCTTGGCGCAACAGCCCTGCGCGATGATAAAACGGTCGGTTTTGGGGTCAAAGGCATTCACCAAGACCATCAAGCTATGG
AGAAACGTATTTTAGAAGAATTAAGAAAAACTTACCGCCCAGAATTTATCAATCGTATTGATGAAAAAGTGGTCTTTCAT
AGTCTGACCCAAGATAACATGCGCGATGTGGTTAAAATCATGGTACAGCCCCTGATTACTACATTGGCAGAAAAAGGTAT
TACCCTTAAAATTCAGCCTTTGGCCTTGAAACATTTGTCCGAGGTCGGCTATGATGAGCATATGGGGGCAAGACCATTAC
GTCGAACGCTGCAAACTGAGATAGAAGATAAGCTATCAGAGCTTATTCTTTCTCGAGAATTGACAAGTGGGCATACGCTA
AAAATTGGATTATCACATGGCAAATTAACGTTTCACATAGCTTAA

Domains

Predicted by InterproScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(722-801)

AAA domain (Cdc48 subfamily) (AAA_2)

(544-715)

AAA lid domain (AAA_lid_9)

(376-460)

Clp amino terminal domain, pathogenicity island component (Clp_N)

(95-130)

ATPase family associated with various cellular activities (AAA) (AAA)

(236-368)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpC Streptococcus mutans UA159

75.154

99.877

0.751
  clpC Streptococcus thermophilus LMG 18311

71.324

100

0.715
  clpC Streptococcus thermophilus LMD-9

71.201

100

0.714
  clpC Streptococcus pneumoniae TIGR4

65.971

100

0.66
  clpC Streptococcus pneumoniae Rx1

65.971

100

0.66
  clpC Streptococcus pneumoniae D39

65.971

100

0.66
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.971

100

0.494
  clpC Bacillus subtilis subsp. subtilis str. 168

42.326

100

0.434

Multiple sequence alignment