Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   DQM73_RS03385 Genome accession   NZ_LS483346
Coordinates   649528..651798 (-) Length   756 a.a.
NCBI ID   WP_002925552.1    Uniprot ID   A0A2X3XHE5
Organism   Streptococcus sanguinis strain NCTC11085     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 644528..656798
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM73_RS03350 (NCTC11085_00654) - 645923..646378 (-) 456 WP_002925562.1 MarR family winged helix-turn-helix transcriptional regulator -
  DQM73_RS03355 (NCTC11085_00655) - 646401..646835 (+) 435 WP_002925561.1 GNAT family N-acetyltransferase -
  DQM73_RS03360 (NCTC11085_00656) - 646861..647163 (-) 303 WP_002896152.1 DUF1827 family protein -
  DQM73_RS03365 (NCTC11085_00657) - 647231..647680 (-) 450 WP_002925555.1 NUDIX hydrolase -
  DQM73_RS03375 (NCTC11085_00658) - 647906..648805 (+) 900 WP_002925554.1 YafY family protein -
  DQM73_RS03380 (NCTC11085_00659) - 648865..649479 (+) 615 WP_002925553.1 GyrI-like domain-containing protein -
  DQM73_RS03385 (NCTC11085_00660) clpE 649528..651798 (-) 2271 WP_002925552.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  DQM73_RS03390 (NCTC11085_00661) - 652048..652278 (+) 231 WP_002925551.1 DUF1797 family protein -
  DQM73_RS03395 (NCTC11085_00662) - 652468..653322 (+) 855 WP_002925550.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  DQM73_RS03400 (NCTC11085_00663) - 653319..654092 (+) 774 WP_002925549.1 HAD hydrolase family protein -
  DQM73_RS03405 (NCTC11085_00664) - 654200..655042 (+) 843 WP_002925548.1 NAD(P)H-hydrate dehydratase -
  DQM73_RS12525 - 655018..655254 (+) 237 WP_002896141.1 hypothetical protein -
  DQM73_RS03415 (NCTC11085_00665) xseA 655199..656539 (+) 1341 WP_002921922.1 exodeoxyribonuclease VII large subunit -
  DQM73_RS03420 (NCTC11085_00666) - 656517..656729 (+) 213 WP_002896137.1 exodeoxyribonuclease VII small subunit -

Sequence

Protein


Download         Length: 756 a.a.        Molecular weight: 83641.64 Da        Isoelectric Point: 4.9757

>NTDB_id=1137693 DQM73_RS03385 WP_002925552.1 649528..651798(-) (clpE) [Streptococcus sanguinis strain NCTC11085]
MLCQNCKINESTIHLYTNVNGHKQQVDLCQNCYQIMKTDSEHSLFGGIANANNHGTDPIDDFFNSLSNFQQPQEPTTPPT
QSGGAYGGGGGYGSNPSKGGQPQPSPQNPKGLLEEFGINVTELARRGEIDPVIGRDEEIVRVIEILNRRTKNNPVLIGEP
GVGKTAVVEGLAQKIVDGDVPHKLQGKEVIRLDVVSLVQGTGIRGQFEERMQKLIDEIRSRQDVILFIDEIHEIVGAGSA
GDGNMDAGNILKPALARGELQMVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETITILKGIQKKYEDYHHVKYTDAA
IEAAALLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKAQATRDEDFEKAAYFRDQIAKYKEL
QQTSVLDKDTPIISEKTIEHIVEQKTNIPVGDLKEKEQSQLVNLASDLKAHVIGQDDAVDKIAKAIRRNRVGLGSPNRPI
GSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTERVRRNPYSLILLDE
VEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDAIIIMTSNAGTGKAEASVGFGAAREGRTNSVLGELGNFFSPEFMNRF
DGIIEFQALSKDNLLQIVNLMLDDVNQRLATNDIHLDVTEKVKEKLVDLGYDPKMGARPLRRTIQDHIEDAITDFYLENP
SEKELKAIMTSNGKILIKSAKKTESTESVHSSQEEK

Nucleotide


Download         Length: 2271 bp        

>NTDB_id=1137693 DQM73_RS03385 WP_002925552.1 649528..651798(-) (clpE) [Streptococcus sanguinis strain NCTC11085]
ATGCTTTGTCAAAATTGTAAAATCAATGAATCTACGATTCACCTTTATACCAACGTAAATGGCCATAAACAACAGGTGGA
TTTGTGTCAAAACTGCTACCAAATCATGAAAACAGACTCCGAACATTCCTTGTTCGGTGGGATTGCTAATGCCAACAATC
ACGGAACAGATCCTATTGATGACTTCTTCAACAGTCTCAGCAATTTTCAACAGCCTCAGGAACCAACTACTCCTCCTACC
CAATCTGGCGGAGCCTATGGAGGCGGTGGCGGCTACGGTTCCAATCCTAGCAAGGGTGGTCAGCCTCAGCCAAGTCCGCA
AAATCCAAAAGGCCTGCTGGAAGAGTTTGGTATCAACGTGACTGAGTTGGCTCGCCGAGGTGAGATTGACCCTGTTATTG
GCCGTGATGAAGAAATCGTCCGTGTCATTGAAATCCTCAACCGCCGCACTAAAAACAATCCTGTTCTCATAGGAGAGCCA
GGAGTCGGAAAAACAGCCGTGGTGGAAGGTCTTGCCCAGAAAATTGTTGATGGTGATGTGCCTCATAAACTCCAAGGCAA
GGAAGTTATCCGCCTAGACGTTGTCAGTTTAGTACAGGGAACTGGTATCCGTGGCCAATTTGAGGAGAGAATGCAGAAGC
TCATTGATGAGATTCGTTCTCGTCAGGATGTCATTCTCTTCATTGATGAAATCCATGAAATTGTCGGAGCAGGCTCAGCT
GGCGATGGCAATATGGACGCTGGGAACATTCTCAAACCAGCTCTGGCTCGCGGAGAACTCCAGATGGTCGGAGCAACCAC
TCTCAATGAATACCGTATCATTGAGAAGGACGCTGCACTAGAGCGCCGTATGCAACCCGTTAAGGTAGACGAGCCGACGG
TAGAAGAAACCATTACCATCCTCAAAGGGATTCAGAAAAAATACGAAGACTACCATCACGTCAAGTACACAGATGCGGCC
ATCGAAGCTGCTGCGCTTCTCTCCAACCGCTACATCCAAGATCGCTTCTTGCCAGACAAGGCTATTGACCTCTTGGATGA
GGCTGGATCCAAGATGAATCTGACCCTCAACTTTGTTGACCCCAAGGTCATTGACCAACGTCTGATTGAGGCCGAAAACC
TCAAGGCTCAGGCGACTCGTGACGAAGATTTCGAGAAAGCAGCTTACTTCCGCGACCAGATTGCCAAGTACAAGGAACTC
CAGCAGACAAGTGTGCTAGACAAGGATACTCCGATTATCAGCGAGAAAACGATTGAGCATATCGTAGAGCAAAAGACCAA
TATCCCAGTTGGCGACCTCAAAGAAAAAGAACAGTCTCAGCTGGTCAATCTTGCCAGTGACTTAAAGGCTCATGTCATCG
GTCAAGACGATGCTGTGGATAAGATTGCCAAGGCCATCCGCCGCAACCGGGTCGGACTGGGAAGTCCTAATCGCCCAATC
GGCAGCTTCCTCTTTGTCGGACCAACTGGTGTCGGTAAGACTGAGCTGTCTAAGCAACTAGCTATTGAGCTCTTTGGCTC
GGCTGACAGCATGATTCGCTTTGATATGAGTGAATACATGGAGAAACACAGCGTGGCCAAGCTGGTCGGTGCCCCTCCGG
GCTATGTCGGCTATGATGAAGCTGGTCAATTGACTGAGCGCGTCCGCCGCAATCCCTACTCGCTCATTCTGCTGGATGAG
GTGGAAAAAGCCCATCCCGATGTTATGCACATGTTCCTGCAGGTTCTAGATGATGGCCGCCTGACCGATGGCCAAGGCCG
GACTGTCAGCTTCAAGGACGCCATTATCATCATGACATCCAATGCCGGAACTGGCAAAGCTGAAGCCAGCGTTGGCTTTG
GAGCAGCGCGTGAAGGCCGCACCAACTCCGTCTTGGGTGAATTGGGCAACTTCTTCAGTCCTGAATTTATGAATCGCTTT
GACGGCATTATCGAATTCCAGGCGCTCAGCAAGGACAATCTACTGCAAATCGTCAACCTTATGCTGGACGATGTTAATCA
ACGTTTGGCAACCAATGACATTCATCTGGATGTTACGGAGAAGGTCAAGGAAAAATTGGTTGACCTGGGCTACGATCCAA
AAATGGGCGCTCGCCCACTGCGCCGTACCATTCAGGACCATATCGAAGATGCTATTACTGACTTTTATCTGGAAAATCCA
AGCGAAAAAGAGCTCAAAGCTATCATGACCAGCAATGGCAAGATTCTCATCAAGTCAGCCAAGAAAACTGAAAGCACAGA
GTCCGTTCATTCATCACAAGAAGAAAAATAA

Domains

Predicted by InterproScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(649-723)

ATPase family associated with various cellular activities (AAA) (AAA)

(155-274)

AAA lid domain (AAA_lid_9)

(293-390)

AAA domain (Cdc48 subfamily) (AAA_2)

(478-641)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2X3XHE5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

86.394

100

0.865
  clpE Streptococcus pneumoniae D39

86.394

100

0.865
  clpE Streptococcus pneumoniae R6

86.394

100

0.865
  clpE Streptococcus pneumoniae TIGR4

86.262

100

0.864
  clpE Streptococcus mutans UA159

83.709

99.868

0.836
  clpC Lactococcus lactis subsp. cremoris KW2

76.378

100

0.77
  clpC Bacillus subtilis subsp. subtilis str. 168

48.615

95.503

0.464
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.692

85.979

0.41
  clpC Streptococcus pneumoniae Rx1

48.47

82.143

0.398
  clpC Streptococcus pneumoniae D39

48.47

82.143

0.398
  clpC Streptococcus pneumoniae TIGR4

48.309

82.143

0.397
  clpC Streptococcus thermophilus LMD-9

47.284

82.804

0.392
  clpC Streptococcus thermophilus LMG 18311

46.965

82.804

0.389
  clpC Streptococcus mutans UA159

46.805

82.804

0.388

Multiple sequence alignment