Detailed information NTG1134901

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: JM183_RS04350
• Genome accession: NZ_LR962863
• Coordinates: 957540..958583 (+)
• Length: 347 a.a.
• NCBI ID: WP_050330549.1
• Uniprot ID: A0A0K1ACB9
• Organism: Staphylococcus schleiferi strain NCTC12218
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 952540..963583

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JM183_RS04325 (NCTC12218_00918)	-	952962..954101 (+)	1140	WP_236744746.1	exo-alpha-sialidase	-
JM183_RS04330 (NCTC12218_00920)	-	954485..955483 (-)	999	Protein_860	FUSC family protein	-
JM183_RS04335 (NCTC12218_00921)	map	955581..956342 (+)	762	WP_016425510.1	type I methionyl aminopeptidase	-
JM183_RS04340 (NCTC12218_00922)	-	956440..956829 (+)	390	WP_016425509.1	hypothetical protein	-
JM183_RS04345 (NCTC12218_00923)	liaF	956842..957543 (+)	702	WP_016425508.1	cell wall-active antibiotics response protein LiaF	-
JM183_RS04350 (NCTC12218_00924)	vraS	957540..958583 (+)	1044	WP_050330549.1	sensor histidine kinase	Regulator
JM183_RS04355 (NCTC12218_00925)	vraR	958573..959202 (+)	630	WP_016425506.1	response regulator transcription factor	Regulator
JM183_RS04360 (NCTC12218_00926)	-	959257..959829 (-)	573	WP_016425505.1	beta-class carbonic anhydrase	-
JM183_RS04365 (NCTC12218_00928)	-	959862..961122 (-)	1261	Protein_867	YihY/virulence factor BrkB family protein	-
JM183_RS04370 (NCTC12218_00929)	-	961413..961700 (-)	288	WP_016425503.1	YtxH domain-containing protein	-
JM183_RS04375 (NCTC12218_00930)	-	961708..962166 (-)	459	WP_016425502.1	low molecular weight protein-tyrosine-phosphatase	-
JM183_RS04380 (NCTC12218_00931)	-	962299..962502 (+)	204	WP_016425501.1	DUF1128 family protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40139.47 Da
• Isoelectric Point: 5.4523

>NTDB_id=1134901 JM183_RS04350 WP_050330549.1 957540..958583(+) (vraS) [Staphylococcus schleiferi strain NCTC12218]
MNHYVRAIGSMLILVYSMFTAFFFIDKVFTNIIYFQGMFYTQIFGIPVFIFLNLIVIFLCIIVGSVLAYKINQQNDWLKQ
QIERAFEGETVGINDQHIELYNETIELYQALVPLNQELHKMRIKTQNLTNESYNMNDLKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELTPPLDQQIPTLEKMVQDSQLEMRALLLHLRPIGLKDRSLGEGIKSLVTDLQRKVPMKVVQEI
DEFEVPKGIEDHLFRITQEAISNTLRHAKGKQVTVELLNREDYLLLRIQDDGIGFNVDDKLEQSYGLKNMRERAIEIGAT
FHIVSLPDAGTRIEVKAPLDKEVHNDN

Nucleotide

• Length: 1044 bp

>NTDB_id=1134901 JM183_RS04350 WP_050330549.1 957540..958583(+) (vraS) [Staphylococcus schleiferi strain NCTC12218]
ATGAACCATTACGTTCGTGCCATAGGCTCAATGTTGATTTTAGTCTACAGTATGTTTACTGCTTTTTTCTTTATTGATAA
AGTCTTTACTAATATCATTTATTTTCAAGGCATGTTTTATACCCAGATTTTTGGGATTCCCGTATTTATCTTTTTAAATT
TAATCGTTATCTTTCTTTGTATCATTGTAGGTAGCGTACTTGCCTATAAAATCAATCAACAAAATGATTGGTTGAAGCAA
CAAATTGAACGTGCATTTGAAGGGGAAACAGTAGGGATCAATGACCAACATATCGAATTATATAATGAGACGATTGAACT
GTATCAAGCCCTTGTTCCTTTGAATCAAGAACTTCATAAAATGCGTATTAAAACTCAAAATTTAACGAACGAATCTTATA
ATATGAACGATTTGAAAGTGAAAAAAATAATTGAAGATGAGAGACAACGGTTGGCTAGGGAATTACACGATAGTGTGTCC
CAACAACTCTTTGCGGCAAGCATGATGTTATCCGCGATTAAAGAAACAGAGTTAACCCCACCACTCGATCAGCAAATTCC
AACTTTAGAGAAAATGGTCCAAGATTCTCAGTTGGAGATGCGGGCGTTATTGTTACATTTGAGACCGATAGGACTTAAAG
ACCGCTCGTTAGGTGAAGGTATTAAATCATTAGTTACAGATCTACAAAGAAAAGTTCCAATGAAAGTTGTACAAGAAATT
GACGAATTTGAAGTGCCAAAAGGGATAGAAGACCACTTATTTCGAATCACTCAAGAAGCCATCTCTAATACATTACGTCA
TGCTAAAGGGAAACAAGTTACTGTCGAATTGCTCAATCGTGAAGACTATTTATTGTTGCGTATTCAAGATGACGGTATCG
GTTTTAATGTAGATGACAAATTAGAGCAAAGTTATGGACTTAAAAATATGCGTGAACGTGCAATAGAAATCGGGGCAACC
TTTCATATCGTTTCATTGCCAGACGCTGGGACGAGAATAGAAGTAAAGGCACCACTTGATAAGGAGGTACATAATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase (HisKA_3) (147-210)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

3D structure

• AlphaFold DB: A0A0K1ACB9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	84.438	100	0.844