Detailed information
Bioinformatically predicted
Overview
| Name | sepM | Type | Regulator |
| Locus tag | H1W94_RS07700 | Genome accession | NZ_LR822041 |
| Coordinates | 1475633..1476709 (-) | Length | 358 a.a. |
| NCBI ID | WP_011226464.1 | Uniprot ID | - |
| Organism | Streptococcus thermophilus isolate STH_CIRM_1122 | ||
| Function | processing of CSP (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1454729..1539079 | 1475633..1476709 | within | 0 |
Gene organization within MGE regions
Location: 1454729..1539079
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H1W94_RS07600 (STHERMO_1671) | gatA | 1455995..1457461 (-) | 1467 | WP_002946584.1 | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA | - |
| H1W94_RS07605 (STHERMO_1672) | gatC | 1457461..1457763 (-) | 303 | WP_002884769.1 | Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC | - |
| H1W94_RS07610 (STHERMO_1673) | - | 1457903..1458157 (-) | 255 | WP_011226449.1 | glycosyl transferase | - |
| H1W94_RS07615 (STHERMO_1674) | - | 1458170..1458379 (-) | 210 | WP_011226450.1 | glycosyltransferase | - |
| H1W94_RS07620 | - | 1458695..1460136 (-) | 1442 | Protein_1436 | 6-phospho-beta-glucosidase | - |
| H1W94_RS07625 (STHERMO_1677) | msrA | 1460289..1460798 (-) | 510 | WP_002946589.1 | peptide-methionine (S)-S-oxide reductase MsrA | - |
| H1W94_RS07630 (STHERMO_1678) | - | 1460810..1461658 (-) | 849 | WP_041828318.1 | MetQ/NlpA family ABC transporter substrate-binding protein | - |
| H1W94_RS07635 (STHERMO_1679) | - | 1461781..1462332 (-) | 552 | WP_002946999.1 | cysteine hydrolase family protein | - |
| H1W94_RS07640 (STHERMO_1680) | codY | 1462395..1463180 (-) | 786 | WP_002951720.1 | GTP-sensing pleiotropic transcriptional regulator CodY | - |
| H1W94_RS07645 (STHERMO_1681) | - | 1463440..1464654 (-) | 1215 | WP_011226456.1 | pyridoxal phosphate-dependent aminotransferase | - |
| H1W94_RS07650 (STHERMO_1682) | - | 1465009..1465461 (+) | 453 | WP_002946987.1 | universal stress protein | - |
| H1W94_RS09915 | - | 1465641..1466212 (+) | 572 | Protein_1443 | IS30 family transposase | - |
| H1W94_RS07655 (STHERMO_1686) | - | 1466428..1466898 (-) | 471 | WP_011227497.1 | membrane protein | - |
| H1W94_RS07660 (STHERMO_1688) | pflA | 1467104..1467904 (-) | 801 | WP_002946980.1 | pyruvate formate-lyase-activating protein | - |
| H1W94_RS07665 | - | 1468092..1468202 (-) | 111 | WP_014621906.1 | LPXTG cell wall anchor domain-containing protein | - |
| H1W94_RS07670 (STHERMO_1690) | - | 1468900..1470231 (-) | 1332 | WP_002951727.1 | hemolysin family protein | - |
| H1W94_RS07675 (STHERMO_1691) | - | 1470344..1471126 (+) | 783 | WP_011226459.1 | ABC transporter ATP-binding protein | - |
| H1W94_RS07680 (STHERMO_1693) | - | 1471745..1473811 (-) | 2067 | WP_011227498.1 | cation:proton antiporter | - |
| H1W94_RS07685 (STHERMO_1694) | - | 1473820..1474062 (-) | 243 | WP_011227499.1 | hypothetical protein | - |
| H1W94_RS07690 (STHERMO_1695) | - | 1474059..1474607 (-) | 549 | WP_004197152.1 | tRNA (mnm(5)s(2)U34)-methyltransferase | - |
| H1W94_RS07695 (STHERMO_1696) | - | 1474604..1475548 (-) | 945 | WP_011226463.1 | TIGR01212 family radical SAM protein | - |
| H1W94_RS07700 (STHERMO_1697) | sepM | 1475633..1476709 (-) | 1077 | WP_011226464.1 | SepM family pheromone-processing serine protease | Regulator |
| H1W94_RS07705 (STHERMO_1698) | coaD | 1476687..1477184 (-) | 498 | WP_011226465.1 | pantetheine-phosphate adenylyltransferase | - |
| H1W94_RS07710 (STHERMO_1699) | rsmD | 1477218..1477817 (-) | 600 | WP_011227500.1 | 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD | - |
| H1W94_RS07715 (STHERMO_1700) | trxB | 1477908..1478861 (-) | 954 | WP_255136104.1 | thioredoxin-disulfide reductase | - |
| H1W94_RS07720 (STHERMO_1701) | - | 1478894..1479118 (-) | 225 | WP_011226468.1 | DUF4059 family protein | - |
| H1W94_RS07725 (STHERMO_1702) | - | 1479333..1480076 (-) | 744 | WP_011226469.1 | amino acid ABC transporter ATP-binding protein | - |
| H1W94_RS07730 (STHERMO_1703) | - | 1480076..1480822 (-) | 747 | WP_095559509.1 | amino acid ABC transporter permease | - |
| H1W94_RS07735 (STHERMO_1704) | - | 1481211..1482038 (-) | 828 | WP_041827091.1 | transporter substrate-binding domain-containing protein | - |
| H1W94_RS07740 (STHERMO_1705) | - | 1482619..1482852 (-) | 234 | WP_002947030.1 | hypothetical protein | - |
| H1W94_RS07745 (STHERMO_1706) | dinB | 1483138..1484241 (-) | 1104 | WP_011227504.1 | DNA polymerase IV | - |
| H1W94_RS07750 (STHERMO_1707) | pflB | 1484519..1486828 (+) | 2310 | WP_011226473.1 | formate C-acetyltransferase | - |
| H1W94_RS07755 (STHERMO_1708) | - | 1487095..1487877 (+) | 783 | Protein_1464 | carbonic anhydrase | - |
| H1W94_RS07760 | - | 1487928..1488381 (+) | 454 | Protein_1465 | GNAT family N-acetyltransferase | - |
| H1W94_RS07765 (STHERMO_1711) | - | 1488715..1489017 (-) | 303 | WP_231108737.1 | restriction endonuclease subunit S | - |
| H1W94_RS10205 | mobV | 1489063..1489571 (-) | 509 | Protein_1467 | MobV family relaxase | - |
| H1W94_RS07775 (STHERMO_1716) | - | 1490051..1490645 (-) | 595 | Protein_1468 | site-specific integrase | - |
| H1W94_RS07780 (STHERMO_1717) | - | 1490733..1491419 (-) | 687 | WP_011227510.1 | hypothetical protein | - |
| H1W94_RS07785 (STHERMO_1718) | - | 1491495..1492250 (-) | 756 | WP_002951770.1 | ABC transporter permease | - |
| H1W94_RS07790 (STHERMO_1719) | - | 1492247..1492897 (-) | 651 | WP_022096490.1 | ATP-binding cassette domain-containing protein | - |
| H1W94_RS07795 (STHERMO_1721) | - | 1493099..1494055 (-) | 957 | WP_002951776.1 | serine hydrolase domain-containing protein | - |
| H1W94_RS07800 (STHERMO_1722) | - | 1494055..1494810 (-) | 756 | WP_011681560.1 | CppA family protein | - |
| H1W94_RS07805 (STHERMO_1723) | - | 1495163..1496116 (+) | 954 | WP_041826943.1 | IS30 family transposase | - |
| H1W94_RS07810 (STHERMO_1724) | - | 1496337..1496612 (+) | 276 | WP_224103608.1 | CPBP family intramembrane glutamic endopeptidase | - |
| H1W94_RS07815 (STHERMO_1725) | gla | 1496786..1497649 (-) | 864 | WP_002951781.1 | aquaglyceroporin Gla | - |
| H1W94_RS07820 (STHERMO_1726) | - | 1497770..1500037 (+) | 2268 | WP_011227515.1 | Xaa-Pro dipeptidyl-peptidase | - |
| H1W94_RS07825 (STHERMO_1727) | - | 1500389..1501342 (+) | 954 | WP_041826943.1 | IS30 family transposase | - |
| H1W94_RS07830 | - | 1501725..1503115 (+) | 1391 | Protein_1479 | IS3-like element ISSth1b family transposase | - |
| H1W94_RS07835 (STHERMO_1731) | - | 1503261..1503503 (-) | 243 | WP_011227518.1 | Blp family class II bacteriocin | - |
| H1W94_RS07840 (STHERMO_1732) | - | 1503753..1504484 (+) | 732 | WP_002948869.1 | LytR/AlgR family response regulator transcription factor | - |
| H1W94_RS09920 | - | 1505021..1505824 (+) | 804 | WP_224103634.1 | ATP-binding protein | - |
| H1W94_RS07850 (STHERMO_1734) | - | 1505842..1506003 (-) | 162 | WP_011226496.1 | ComC/BlpC family leader-containing pheromone/bacteriocin | - |
| H1W94_RS07855 (STHERMO_1735) | - | 1506018..1507386 (-) | 1369 | Protein_1484 | bacteriocin secretion accessory protein | - |
| H1W94_RS07860 (STHERMO_1738) | comA/nlmT | 1507402..1509555 (-) | 2154 | WP_059257386.1 | peptide cleavage/export ABC transporter | Regulator |
| H1W94_RS07865 (STHERMO_1741) | - | 1510569..1512314 (-) | 1746 | WP_011226501.1 | ABC transporter ATP-binding protein | - |
| H1W94_RS07870 (STHERMO_1742) | - | 1512307..1514064 (-) | 1758 | WP_011226502.1 | ABC transporter ATP-binding protein | - |
| H1W94_RS09925 (STHERMO_1744) | - | 1514252..1514458 (-) | 207 | WP_002948879.1 | hypothetical protein | - |
| H1W94_RS07880 (STHERMO_1745) | - | 1514663..1515190 (-) | 528 | WP_011227521.1 | VanZ family protein | - |
| H1W94_RS07885 (STHERMO_1746) | rlmN | 1515192..1516361 (-) | 1170 | WP_011227522.1 | 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN | - |
| H1W94_RS07890 (STHERMO_1747) | - | 1516365..1517087 (-) | 723 | WP_011226505.1 | YutD family protein | - |
| H1W94_RS07895 (STHERMO_1748) | - | 1517142..1518497 (-) | 1356 | WP_059257451.1 | bifunctional metallophosphatase/5'-nucleotidase | - |
| H1W94_RS10095 (STHERMO_1749) | - | 1518776..1518907 (-) | 132 | WP_258380174.1 | hypothetical protein | - |
| H1W94_RS07900 (STHERMO_1751) | - | 1519345..1520688 (-) | 1344 | WP_002948888.1 | DEAD/DEAH box helicase | - |
| H1W94_RS07905 (STHERMO_1752) | mraY | 1520763..1521785 (-) | 1023 | WP_011227524.1 | phospho-N-acetylmuramoyl-pentapeptide- transferase | - |
| H1W94_RS07910 (STHERMO_1753) | pbp2X | 1521787..1524054 (-) | 2268 | WP_011226508.1 | penicillin-binding protein PBP2X | - |
| H1W94_RS07915 (STHERMO_1754) | ftsL | 1524058..1524378 (-) | 321 | WP_011226509.1 | cell division protein FtsL | - |
| H1W94_RS07920 (STHERMO_1755) | rsmH | 1524381..1525331 (-) | 951 | WP_002888254.1 | 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH | - |
| H1W94_RS09930 (STHERMO_1756) | - | 1525499..1525849 (-) | 351 | WP_011227526.1 | hypothetical protein | - |
| H1W94_RS09935 (STHERMO_1757) | - | 1525946..1526110 (-) | 165 | WP_231108736.1 | hypothetical protein | - |
| H1W94_RS09940 (STHERMO_1758) | - | 1526107..1526493 (-) | 387 | WP_041827096.1 | hypothetical protein | - |
| H1W94_RS07930 (STHERMO_1760) | - | 1526604..1526858 (-) | 255 | WP_011227529.1 | Wzz/FepE/Etk N-terminal domain-containing protein | - |
| H1W94_RS07935 (STHERMO_1761) | - | 1527132..1527488 (-) | 357 | WP_011226513.1 | DUF805 domain-containing protein | - |
| H1W94_RS07940 (STHERMO_1763) | - | 1527708..1527977 (-) | 270 | WP_011226514.1 | hypothetical protein | - |
| H1W94_RS07945 (STHERMO_1764) | - | 1528358..1529608 (-) | 1251 | WP_011226515.1 | glutamate-5-semialdehyde dehydrogenase | - |
| H1W94_RS07950 (STHERMO_1765) | proB | 1529610..1530413 (-) | 804 | WP_002948808.1 | glutamate 5-kinase | - |
| H1W94_RS07955 (STHERMO_1766) | - | 1530534..1532123 (-) | 1590 | WP_011226516.1 | hypothetical protein | - |
| H1W94_RS07960 (STHERMO_1767) | - | 1532126..1532858 (-) | 733 | Protein_1508 | ABC transporter ATP-binding protein | - |
| H1W94_RS07965 (STHERMO_1770) | - | 1533132..1533865 (+) | 734 | Protein_1509 | DUF554 domain-containing protein | - |
| H1W94_RS07970 (STHERMO_1772) | addA | 1534259..1537912 (-) | 3654 | WP_011227531.1 | helicase-exonuclease AddAB subunit AddA | - |
Sequence
Protein
Download Length: 358 a.a. Molecular weight: 39232.11 Da Isoelectric Point: 9.4944
>NTDB_id=1132078 H1W94_RS07700 WP_011226464.1 1475633..1476709(-) (sepM) [Streptococcus thermophilus isolate STH_CIRM_1122]
MANKTKSKSLLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYTQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGVLN
IADTVTAVNGKTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK
MANKTKSKSLLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYTQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGVLN
IADTVTAVNGKTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK
Nucleotide
Download Length: 1077 bp
>NTDB_id=1132078 H1W94_RS07700 WP_011226464.1 1475633..1476709(-) (sepM) [Streptococcus thermophilus isolate STH_CIRM_1122]
GTGGCAAACAAGACAAAATCTAAATCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATACTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAAGACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA
GTGGCAAACAAGACAAAATCTAAATCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATACTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAAGACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| sepM | Streptococcus mutans UA159 |
62.757 |
95.251 |
0.598 |