Detailed information NTG1128351

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: FJH52_RS09350
• Genome accession: NZ_LR595848
• Coordinates: 1862020..1863057 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727278.1
• Uniprot ID: A0A4J2BD57
• Organism: Streptococcus pneumoniae strain 4559 isolate 4559
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1857020..1868057

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FJH52_RS09325	-	1857759..1859090 (-)	1332	WP_000390043.1	hemolysin family protein	-
FJH52_RS09330	endA	1859381..1860205 (-)	825	WP_001036789.1	DNA-entry nuclease EndA	Machinery gene
FJH52_RS09335	-	1860244..1860432 (-)	189	WP_001813390.1	DNA-directed RNA polymerase subunit beta	-
FJH52_RS09340	murA	1860425..1861708 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
FJH52_RS09345	-	1861732..1861962 (-)	231	WP_000250392.1	DUF1146 family protein	-
FJH52_RS09350	sepM	1862020..1863057 (-)	1038	WP_000727278.1	SepM family pheromone-processing serine protease	Regulator
FJH52_RS09355	coaD	1863041..1863529 (-)	489	WP_001280769.1	pantetheine-phosphate adenylyltransferase	-
FJH52_RS09360	rsmD	1863519..1864058 (-)	540	WP_000706963.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
FJH52_RS09365	asnA	1864123..1865115 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
FJH52_RS09370	-	1865228..1865911 (-)	684	WP_001016913.1	Bax inhibitor-1/YccA family protein	-
FJH52_RS09375	-	1865967..1866707 (-)	741	WP_000152698.1	RNA methyltransferase	-
FJH52_RS09380	-	1866741..1867019 (+)	279	WP_001174612.1	acylphosphatase	-
FJH52_RS09385	yidC	1867097..1868023 (+)	927	WP_000835955.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37510.55 Da
• Isoelectric Point: 5.0724

>NTDB_id=1128351 FJH52_RS09350 WP_000727278.1 1862020..1863057(-) (sepM) [Streptococcus pneumoniae strain 4559 isolate 4559]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNSP

Nucleotide

• Length: 1038 bp

>NTDB_id=1128351 FJH52_RS09350 WP_000727278.1 1862020..1863057(-) (sepM) [Streptococcus pneumoniae strain 4559 isolate 4559]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACGGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAAATCATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGTCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAGTCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A4J2BD57

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	60	98.551	0.591