Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpX   Type   Regulator
Locus tag   FGL00_RS04425 Genome accession   NZ_LR594034
Coordinates   869451..870680 (+) Length   409 a.a.
NCBI ID   WP_003054192.1    Uniprot ID   -
Organism   Streptococcus dysgalactiae subsp. equisimilis strain NCTC8546     
Function   require for competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 861687..878170 869451..870680 within 0


Gene organization within MGE regions


Location: 861687..878170
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FGL00_RS04375 (NCTC8546_00901) - 861777..862705 (-) 929 Protein_805 IS30 family transposase -
  FGL00_RS04380 (NCTC8546_00903) - 862779..863147 (+) 369 Protein_806 transposase -
  FGL00_RS04385 (NCTC8546_00905) - 863217..864322 (+) 1106 WP_138098369.1 IS3 family transposase -
  FGL00_RS04390 (NCTC8546_00906) - 864365..864577 (+) 213 Protein_808 transposase -
  FGL00_RS04395 (NCTC8546_00907) - 864601..864885 (-) 285 WP_065957083.1 hypothetical protein -
  FGL00_RS04400 (NCTC8546_00908) - 865073..866350 (-) 1278 WP_138098371.1 hydroxymethylglutaryl-CoA reductase, degradative -
  FGL00_RS04405 (NCTC8546_00909) - 866331..867512 (-) 1182 WP_065957085.1 hydroxymethylglutaryl-CoA synthase -
  FGL00_RS04410 (NCTC8546_00910) - 867730..868569 (+) 840 WP_003054196.1 thymidylate synthase -
  FGL00_RS04415 (NCTC8546_00911) - 868650..869147 (+) 498 WP_003054187.1 dihydrofolate reductase -
  FGL00_RS04420 (NCTC8546_00912) - 869167..869337 (+) 171 WP_003054200.1 hypothetical protein -
  FGL00_RS04425 (NCTC8546_00913) clpX 869451..870680 (+) 1230 WP_003054192.1 ATP-dependent Clp protease ATP-binding subunit ClpX Regulator
  FGL00_RS04430 (NCTC8546_00914) yihA 870690..871289 (+) 600 WP_012766850.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
  FGL00_RS04435 (NCTC8546_00915) - 871433..872176 (+) 744 WP_138098373.1 hypothetical protein -
  FGL00_RS04440 (NCTC8546_00916) - 872233..874332 (-) 2100 WP_138098375.1 ATP-dependent Clp protease ATP-binding subunit -
  FGL00_RS04445 - 874830..875237 (-) 408 Protein_819 IS30 family transposase -
  FGL00_RS04450 - 875231..875407 (+) 177 Protein_820 IS30 family transposase -
  FGL00_RS04455 (NCTC8546_00919) rplJ 875736..876236 (+) 501 WP_003050354.1 50S ribosomal protein L10 -
  FGL00_RS04460 rplL 876301..876666 (+) 366 WP_003043797.1 50S ribosomal protein L7/L12 -

Sequence

Protein


Download         Length: 409 a.a.        Molecular weight: 45060.54 Da        Isoelectric Point: 4.5866

>NTDB_id=1127245 FGL00_RS04425 WP_003054192.1 869451..870680(+) (clpX) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC8546]
MAGNRTNDIKVYCSFCGKSQDEVKKIIAGNNVFICNECVALSQEIIKEELAEEVLADLTEVPKPKELLEVLNQYVVGQDR
AKRALSVAVYNHYKRVSFTESRDDEDVELQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENI
LLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTK
NILFIVGGAFDGIEDIVKQRLGEKVIGFGQNSRKIDDNASYMQEIISEDIQKFGLIPEFIGRLPVVAALEQLNTSDLIQI
LTEPRNALVKQYQALLSYDGVELAFDKEALEAIANKAIERKTGARGLRSIIEETMLDIMFEIPSQEDVTKVRITKAAVEG
KSKPVLETA

Nucleotide


Download         Length: 1230 bp        

>NTDB_id=1127245 FGL00_RS04425 WP_003054192.1 869451..870680(+) (clpX) [Streptococcus dysgalactiae subsp. equisimilis strain NCTC8546]
ATGGCAGGAAATCGTACAAACGATATTAAAGTATATTGCTCATTTTGTGGTAAGAGCCAAGACGAAGTCAAAAAAATTAT
TGCAGGGAATAATGTTTTTATCTGTAATGAATGTGTGGCTTTGTCACAAGAAATTATTAAAGAAGAGTTGGCAGAAGAAG
TGTTAGCTGACCTAACAGAAGTTCCAAAACCAAAAGAACTCCTTGAGGTTTTAAACCAGTATGTTGTTGGTCAAGATCGT
GCCAAACGTGCTTTATCAGTAGCTGTTTACAATCATTACAAACGCGTGTCATTCACGGAAAGTCGTGATGATGAAGATGT
TGAATTGCAAAAATCAAACATTTTAATGATTGGTCCAACAGGTTCAGGAAAGACTTTTCTCGCTCAAACCTTAGCTAAGA
GCTTAAATGTTCCTTTTGCGATTGCTGATGCAACCTCACTGACTGAAGCAGGGTATGTTGGAGAAGATGTGGAAAATATT
CTTCTCAAGCTTATCCAAGCAGCTGATTATAATGTGGAACGAGCAGAGCGTGGTATCATCTATGTCGATGAAATTGATAA
GATTGCTAAAAAAGGTGAAAATGTGTCCATCACACGTGATGTTTCTGGTGAGGGAGTTCAACAGGCCTTGCTAAAAATCA
TTGAAGGAACGGTTGCTAGTGTTCCTCCTCAAGGCGGTCGTAAGCATCCAAATCAGGAAATGATTCAAATTGATACCAAG
AATATCTTGTTTATTGTTGGGGGAGCCTTTGATGGCATTGAAGACATTGTCAAACAACGTTTAGGAGAAAAAGTCATTGG
TTTTGGTCAAAACAGCCGAAAAATCGATGACAATGCTTCTTATATGCAAGAGATTATTTCAGAAGATATCCAAAAATTTG
GTCTTATCCCAGAGTTTATTGGACGCTTGCCAGTCGTAGCTGCTCTTGAACAACTAAACACATCAGATTTGATTCAAATT
TTGACGGAACCAAGAAATGCCCTAGTCAAGCAATATCAGGCTCTTCTTTCTTACGATGGTGTCGAATTGGCATTTGATAA
GGAAGCCTTAGAAGCCATTGCAAATAAAGCCATTGAGCGTAAGACAGGCGCGCGTGGTCTTCGTTCTATTATCGAAGAAA
CGATGTTAGACATTATGTTTGAAATTCCAAGCCAAGAAGATGTCACAAAAGTGCGTATCACCAAGGCTGCTGTCGAAGGC
AAGTCAAAACCCGTTTTAGAGACAGCTTAA

Domains

Predicted by InterproScan.

AAA domain (Cdc48 subfamily) (AAA_2)

(110-305)

ClpX C4-type zinc finger (zf-C4_ClpX)

(12-48)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(312-391)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpX Streptococcus mutans UA159

89.487

100

0.895
  clpX Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

58.853

98.044

0.577

Multiple sequence alignment