Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYH   Type   Machinery gene
Locus tag   FGK81_RS09085 Genome accession   NZ_LR590466
Coordinates   1764270..1765223 (-) Length   317 a.a.
NCBI ID   WP_002987790.1    Uniprot ID   A0A5S4TCX5
Organism   Streptococcus pyogenes strain NCTC8193     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1759270..1770223
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FGK81_RS09050 (NCTC8193_01802) - 1759489..1759806 (-) 318 WP_011888538.1 thioredoxin family protein -
  FGK81_RS09055 (NCTC8193_01803) - 1759803..1760087 (-) 285 WP_011888537.1 DUF4651 domain-containing protein -
  FGK81_RS09065 (NCTC8193_01804) pepA 1760552..1761619 (+) 1068 WP_011184093.1 glutamyl aminopeptidase -
  FGK81_RS09070 (NCTC8193_01805) proC 1761667..1762437 (+) 771 WP_002986527.1 pyrroline-5-carboxylate reductase -
  FGK81_RS09075 - 1762520..1762828 (-) 309 WP_011017251.1 hypothetical protein -
  FGK81_RS09080 (NCTC8193_01806) - 1763015..1764211 (-) 1197 WP_011888536.1 acetate kinase -
  FGK81_RS09085 (NCTC8193_01807) comYH 1764270..1765223 (-) 954 WP_002987790.1 class I SAM-dependent methyltransferase Machinery gene
  FGK81_RS09090 (NCTC8193_01808) comGG 1765321..1765647 (-) 327 WP_002986539.1 competence type IV pilus minor pilin ComGG -
  FGK81_RS09095 (NCTC8193_01809) comYF 1765631..1766065 (-) 435 WP_002986542.1 competence type IV pilus minor pilin ComGF Machinery gene
  FGK81_RS09100 (NCTC8193_01810) comGE 1766058..1766342 (-) 285 WP_041174183.1 competence type IV pilus minor pilin ComGE -
  FGK81_RS09105 (NCTC8193_01811) comGD 1766299..1766727 (-) 429 WP_002986548.1 competence type IV pilus minor pilin ComGD -
  FGK81_RS09110 (NCTC8193_01812) comYC 1766702..1767028 (-) 327 WP_002986552.1 competence type IV pilus major pilin ComGC Machinery gene
  FGK81_RS09115 (NCTC8193_01813) comYB 1767030..1768064 (-) 1035 WP_011054115.1 competence type IV pilus assembly protein ComGB Machinery gene
  FGK81_RS09120 (NCTC8193_01814) comYA 1768000..1768938 (-) 939 WP_011888534.1 competence type IV pilus ATPase ComGA Machinery gene
  FGK81_RS09125 (NCTC8193_01815) - 1769031..1769396 (-) 366 WP_002986560.1 DUF1033 family protein -

Sequence

Protein


Download         Length: 317 a.a.        Molecular weight: 35985.08 Da        Isoelectric Point: 4.7205

>NTDB_id=1126807 FGK81_RS09085 WP_002987790.1 1764270..1765223(-) (comYH) [Streptococcus pyogenes strain NCTC8193]
MTFEKIEEAYQLLLENCQLIENDLKTHIYDAIVEQNSFYLGAEGASPQVAQNSDKLKALCLTKEEWRKAYQFLFIKAAQT
EQLQANHQFTPDAIGFILLYLLEQLSDKDSLEVLEIGSGTGNLAQTLLNNTSKSLDYVGIELDDLLIDLSASIAEIMDSS
AHFIQEDAVRPQLLKESDIVISDLPVGYYPNDDIAKRYKVASSDKHTYAHHLLMEQSLKYLKKDGFAIFLAPVNLLTSPQ
SQLLKQWLKDYAQVVALITLPDSIFGHPSNAKSIIVLQKQTDHPMETFVYPIRDLKLAENIHDFMENFKKWKLSNVN

Nucleotide


Download         Length: 954 bp        

>NTDB_id=1126807 FGK81_RS09085 WP_002987790.1 1764270..1765223(-) (comYH) [Streptococcus pyogenes strain NCTC8193]
ATGACTTTTGAAAAAATTGAAGAAGCTTATCAGCTGCTCTTAGAGAACTGTCAACTAATTGAAAATGATCTAAAAACACA
TATATACGATGCCATTGTTGAACAAAACTCCTTTTATTTAGGGGCTGAGGGAGCTAGTCCTCAAGTTGCTCAAAATAGTG
ATAAACTGAAAGCCTTGTGCCTGACAAAAGAAGAATGGCGTAAGGCCTACCAGTTTCTTTTTATTAAGGCAGCTCAGACT
GAGCAACTCCAAGCCAACCATCAGTTCACACCAGATGCTATTGGCTTCATTCTGCTGTATCTTTTGGAACAATTGAGTGA
TAAAGATAGCTTAGAGGTACTTGAGATTGGAAGTGGAACAGGGAACCTAGCCCAAACCCTTCTCAACAACACGAGCAAGA
GCCTTGATTATGTAGGGATTGAACTTGATGATCTCTTGATTGATCTGTCAGCCAGTATTGCTGAGATAATGGATTCTTCA
GCCCATTTTATTCAAGAAGATGCGGTAAGGCCTCAATTACTAAAAGAAAGTGACATTGTCATCAGTGACTTACCAGTTGG
TTATTATCCTAACGATGATATTGCCAAACGGTACAAGGTGGCTAGTTCAGATAAGCATACCTATGCCCATCATTTATTAA
TGGAACAGTCTTTAAAATACTTGAAAAAAGACGGTTTTGCGATTTTTCTGGCACCAGTCAATTTATTGACGAGCCCTCAG
AGCCAGTTATTGAAACAGTGGTTAAAAGATTATGCTCAGGTGGTGGCCTTGATTACGCTACCAGATTCTATTTTTGGTCA
TCCCTCTAATGCTAAGTCCATTATTGTCTTACAAAAACAAACAGACCACCCAATGGAAACCTTTGTCTATCCAATTCGGG
ATTTGAAGCTTGCAGAGAATATTCATGATTTTATGGAAAATTTCAAAAAATGGAAACTGAGTAATGTCAATTAA

Domains

Predicted by InterproScan.

N-6 DNA Methylase (N6_Mtase)

(68-288)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5S4TCX5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYH Streptococcus mutans UA159

66.139

99.685

0.659
  comYH Streptococcus mutans UA140

65.823

99.685

0.656

Multiple sequence alignment