Detailed information    

insolico Bioinformatically predicted

Overview

Name   comM   Type   Regulator
Locus tag   E0F34_RS09575 Genome accession   NZ_LR536843
Coordinates   1769787..1770407 (-) Length   206 a.a.
NCBI ID   WP_000839915.1    Uniprot ID   A0A0U0LTQ6
Organism   Streptococcus pneumoniae strain GPSC55 substr. ST3774 isolate b04a6400-1f66-11e7-b93e-3c4a9275d6c8     
Function   fratricide immunity (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1752545..1781477 1769787..1770407 within 0


Gene organization within MGE regions


Location: 1752545..1781477
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  E0F34_RS09495 (SAMEA104035599_01809) - 1752545..1753405 (+) 861 WP_001810270.1 glycerophosphodiester phosphodiesterase family protein -
  E0F34_RS09500 (SAMEA104035599_01810) - 1753389..1754450 (+) 1062 WP_000475761.1 extracellular solute-binding protein -
  E0F34_RS09505 (SAMEA104035599_01811) - 1754467..1755471 (+) 1005 WP_000627599.1 ABC transporter ATP-binding protein -
  E0F34_RS09510 (SAMEA104035599_01812) - 1755483..1757177 (+) 1695 WP_130885247.1 ABC transporter permease -
  E0F34_RS09515 (SAMEA104035599_01813) - 1757179..1757880 (+) 702 WP_001054457.1 MgtC/SapB family protein -
  E0F34_RS09520 (SAMEA104035599_01814) - 1757927..1758526 (+) 600 WP_001021235.1 HAD family hydrolase -
  E0F34_RS09525 (SAMEA104035599_01815) - 1758536..1760563 (+) 2028 WP_000256295.1 ABC transporter substrate-binding protein -
  E0F34_RS09530 - 1760722..1761523 (+) 802 Protein_1795 IS5 family transposase -
  E0F34_RS09535 (SAMEA104035599_01818) lytA 1762156..1763112 (-) 957 WP_000405234.1 N-acetylmuramoyl-L-alanine amidase LytA -
  E0F34_RS09540 (SAMEA104035599_01819) - 1763488..1764858 (-) 1371 WP_001036241.1 MATE family efflux transporter -
  E0F34_RS09550 (SAMEA104035599_01820) recA 1765164..1766330 (-) 1167 WP_001085463.1 recombinase RecA Machinery gene
  E0F34_RS09555 (SAMEA104035599_01821) cinA 1766385..1767641 (-) 1257 WP_130885248.1 competence/damage-inducible protein A Machinery gene
  E0F34_RS09560 (SAMEA104035599_01822) brpA 1767726..1768742 (-) 1017 WP_000239278.1 biofilm formation/cell division transcriptional regulator BrpA -
  E0F34_RS09565 (SAMEA104035599_01823) - 1768750..1769268 (-) 519 WP_000455535.1 GNAT family N-acetyltransferase -
  E0F34_RS09570 (SAMEA104035599_01824) tsaE 1769258..1769701 (-) 444 WP_000288234.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  E0F34_RS09575 (SAMEA104035599_01825) comM 1769787..1770407 (-) 621 WP_000839915.1 hypothetical protein Regulator
  E0F34_RS09585 (SAMEA104035599_01826) - 1770790..1771653 (-) 864 WP_044812437.1 helix-turn-helix domain-containing protein -
  E0F34_RS12190 (SAMEA104035599_01827) - 1771845..1772015 (+) 171 WP_001227862.1 PhrA family quorum-sensing system peptide -
  E0F34_RS09595 (SAMEA104035599_01828) pneA1 1772118..1772342 (+) 225 WP_000181087.1 two-peptide bacteriocin subunit PneA1 -
  E0F34_RS09600 (SAMEA104035599_01829) pneA2 1772349..1772537 (+) 189 WP_000786759.1 two-peptide bacteriocin subunit PneA2 -
  E0F34_RS09605 (SAMEA104035599_01830) - 1772655..1775645 (+) 2991 WP_130885249.1 type 2 lanthipeptide synthetase LanM family protein -
  E0F34_RS09610 (SAMEA104035599_01831) - 1775995..1776699 (+) 705 WP_001033170.1 flavodoxin family protein -
  E0F34_RS09615 (SAMEA104035599_01832) - 1776680..1777609 (+) 930 WP_000912954.1 M50 family metallopeptidase -
  E0F34_RS09620 (SAMEA104035599_01833) - 1777606..1779714 (+) 2109 WP_000701298.1 peptidase domain-containing ABC transporter -
  E0F34_RS09625 (SAMEA104035599_01834) - 1779738..1781477 (+) 1740 WP_000699969.1 S8 family peptidase -

Sequence

Protein


Download         Length: 206 a.a.        Molecular weight: 23580.77 Da        Isoelectric Point: 10.1254

>NTDB_id=1126579 E0F34_RS09575 WP_000839915.1 1769787..1770407(-) (comM) [Streptococcus pneumoniae strain GPSC55 substr. ST3774 isolate b04a6400-1f66-11e7-b93e-3c4a9275d6c8]
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTVFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYIGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF

Nucleotide


Download         Length: 621 bp        

>NTDB_id=1126579 E0F34_RS09575 WP_000839915.1 1769787..1770407(-) (comM) [Streptococcus pneumoniae strain GPSC55 substr. ST3774 isolate b04a6400-1f66-11e7-b93e-3c4a9275d6c8]
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGTTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCTGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTAGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATATTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0U0LTQ6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comM Streptococcus pneumoniae D39

99.515

100

0.995
  comM Streptococcus pneumoniae R6

99.515

100

0.995
  comM Streptococcus pneumoniae TIGR4

99.515

100

0.995
  comM Streptococcus mitis NCTC 12261

38.974

94.66

0.369
  comM Streptococcus mitis SK321

38.974

94.66

0.369

Multiple sequence alignment