Detailed information
Bioinformatically predicted
Overview
| Name | covR | Type | Regulator |
| Locus tag | E0F34_RS02085 | Genome accession | NZ_LR536843 |
| Coordinates | 377502..378191 (+) | Length | 229 a.a. |
| NCBI ID | WP_000518011.1 | Uniprot ID | - |
| Organism | Streptococcus pneumoniae strain GPSC55 substr. ST3774 isolate b04a6400-1f66-11e7-b93e-3c4a9275d6c8 | ||
| Function | repress comR expression (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 376054..423805 | 377502..378191 | within | 0 |
Gene organization within MGE regions
Location: 376054..423805
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E0F34_RS02080 (SAMEA104035599_00393) | gndA | 376066..377490 (+) | 1425 | WP_000158781.1 | NADP-dependent phosphogluconate dehydrogenase | - |
| E0F34_RS02085 (SAMEA104035599_00394) | covR | 377502..378191 (+) | 690 | WP_000518011.1 | response regulator transcription factor | Regulator |
| E0F34_RS02090 (SAMEA104035599_00395) | - | 378289..379184 (+) | 896 | Protein_397 | N-acetylmuramoyl-L-alanine amidase family protein | - |
| E0F34_RS02095 (SAMEA104035599_00396) | mvk | 379306..380184 (+) | 879 | WP_000163315.1 | mevalonate kinase | - |
| E0F34_RS02100 (SAMEA104035599_00397) | mvaD | 380166..381119 (+) | 954 | WP_000373461.1 | diphosphomevalonate decarboxylase | - |
| E0F34_RS02105 (SAMEA104035599_00398) | - | 381106..382113 (+) | 1008 | WP_000562412.1 | phosphomevalonate kinase | - |
| E0F34_RS02110 (SAMEA104035599_00399) | fni | 382097..383107 (+) | 1011 | WP_044812571.1 | type 2 isopentenyl-diphosphate Delta-isomerase | - |
| E0F34_RS02115 (SAMEA104035599_00400) | liaF | 383185..383883 (+) | 699 | WP_061649933.1 | cell wall-active antibiotics response protein LiaF | - |
| E0F34_RS02120 (SAMEA104035599_00401) | - | 383880..384875 (+) | 996 | WP_061649932.1 | sensor histidine kinase | - |
| E0F34_RS02125 (SAMEA104035599_00402) | - | 384889..385521 (+) | 633 | WP_000698432.1 | response regulator transcription factor | - |
| E0F34_RS12100 | - | 385522..385763 (+) | 242 | Protein_405 | DNA alkylation repair protein | - |
| E0F34_RS11730 | - | 385745..386290 (+) | 546 | Protein_406 | DNA alkylation repair protein | - |
| E0F34_RS02145 (SAMEA104035599_00403) | - | 386440..386679 (+) | 240 | WP_000754501.1 | hypothetical protein | - |
| E0F34_RS02150 (SAMEA104035599_00404) | cbpG | 386760..387581 (+) | 822 | WP_050203124.1 | choline-binding protein CbpG | - |
| E0F34_RS02155 | - | 387600..388499 (+) | 900 | Protein_409 | N-acetylmuramoyl-L-alanine amidase family protein | - |
| E0F34_RS11480 | - | 388627..389773 (-) | 1147 | Protein_410 | IS3 family transposase | - |
| E0F34_RS02165 (SAMEA104035599_00410) | - | 389982..391751 (+) | 1770 | WP_050226434.1 | PTS mannitol-specific transporter subunit IIBC | - |
| E0F34_RS02170 (SAMEA104035599_00411) | - | 391775..393730 (+) | 1956 | WP_000927670.1 | BglG family transcription antiterminator | - |
| E0F34_RS02175 (SAMEA104035599_00412) | - | 393732..394169 (+) | 438 | WP_000764147.1 | PTS sugar transporter subunit IIA | - |
| E0F34_RS02180 (SAMEA104035599_00413) | - | 394231..395367 (+) | 1137 | WP_000682977.1 | mannitol-1-phosphate 5-dehydrogenase | - |
| E0F34_RS02190 (SAMEA104035599_00414) | tig | 396153..397436 (+) | 1284 | WP_000116465.1 | trigger factor | - |
| E0F34_RS02195 (SAMEA104035599_00415) | - | 397484..399850 (-) | 2367 | WP_061649930.1 | ATP-dependent RecD-like DNA helicase | - |
| E0F34_RS02200 (SAMEA104035599_00416) | lepB | 400084..400698 (-) | 615 | WP_001048155.1 | signal peptidase I | - |
| E0F34_RS02205 (SAMEA104035599_00417) | rnhC | 400710..401582 (-) | 873 | WP_050220135.1 | ribonuclease HIII | - |
| E0F34_RS02210 (SAMEA104035599_00418) | zapA | 401669..401971 (+) | 303 | WP_000002023.1 | cell division protein ZapA | - |
| E0F34_RS02215 (SAMEA104035599_00419) | - | 401968..402516 (+) | 549 | WP_000622953.1 | CvpA family protein | - |
| E0F34_RS02220 (SAMEA104035599_00420) | - | 402620..404956 (+) | 2337 | WP_001035019.1 | endonuclease MutS2 | - |
| E0F34_RS02225 (SAMEA104035599_00422) | - | 405299..406621 (+) | 1323 | WP_000891489.1 | alanine/glycine:cation symporter family protein | - |
| E0F34_RS02230 (SAMEA104035599_00423) | - | 406839..407387 (+) | 549 | WP_000206761.1 | carboxymuconolactone decarboxylase family protein | - |
| E0F34_RS02235 (SAMEA104035599_00424) | - | 407497..408396 (+) | 900 | WP_000735969.1 | TDT family transporter | - |
| E0F34_RS02240 (SAMEA104035599_00425) | serS | 408421..409695 (-) | 1275 | WP_000884255.1 | serine--tRNA ligase | - |
| E0F34_RS02245 (SAMEA104035599_00427) | - | 409909..410280 (-) | 372 | WP_000079361.1 | DUF956 family protein | - |
| E0F34_RS02250 (SAMEA104035599_00428) | - | 410283..411647 (-) | 1365 | WP_000869675.1 | aspartate kinase | - |
| E0F34_RS12105 | - | 411835..411957 (+) | 123 | WP_001824538.1 | hypothetical protein | - |
| E0F34_RS02260 (SAMEA104035599_00429) | - | 412017..412802 (+) | 786 | WP_000400073.1 | enoyl-CoA hydratase | - |
| E0F34_RS02265 (SAMEA104035599_00430) | - | 412896..413330 (+) | 435 | WP_000386347.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| E0F34_RS02270 (SAMEA104035599_00431) | - | 413330..414304 (+) | 975 | WP_000852948.1 | beta-ketoacyl-ACP synthase III | - |
| E0F34_RS02275 (SAMEA104035599_00432) | - | 414364..414588 (+) | 225 | WP_000257841.1 | acyl carrier protein | - |
| E0F34_RS02280 (SAMEA104035599_00433) | fabK | 414707..415681 (+) | 975 | WP_000857433.1 | enoyl-[acyl-carrier-protein] reductase FabK | - |
| E0F34_RS02285 (SAMEA104035599_00434) | fabD | 415674..416594 (+) | 921 | WP_000167622.1 | ACP S-malonyltransferase | - |
| E0F34_RS02290 (SAMEA104035599_00435) | fabG | 416628..417359 (+) | 732 | WP_000763052.1 | 3-oxoacyl-[acyl-carrier-protein] reductase | - |
| E0F34_RS02295 (SAMEA104035599_00436) | fabF | 417381..418616 (+) | 1236 | WP_000774063.1 | beta-ketoacyl-ACP synthase II | - |
| E0F34_RS02300 (SAMEA104035599_00437) | accB | 418619..419104 (+) | 486 | WP_001052244.1 | acetyl-CoA carboxylase biotin carboxyl carrier protein | - |
| E0F34_RS02305 (SAMEA104035599_00438) | fabZ | 419101..419523 (+) | 423 | WP_000565504.1 | 3-hydroxyacyl-ACP dehydratase FabZ | - |
| E0F34_RS02310 (SAMEA104035599_00439) | accC | 419535..420902 (+) | 1368 | WP_061649929.1 | acetyl-CoA carboxylase biotin carboxylase subunit | - |
| E0F34_RS02315 (SAMEA104035599_00440) | accD | 420939..421805 (+) | 867 | WP_001173353.1 | acetyl-CoA carboxylase, carboxyltransferase subunit beta | - |
| E0F34_RS02320 (SAMEA104035599_00441) | - | 421802..422569 (+) | 768 | WP_033705372.1 | acetyl-CoA carboxylase carboxyl transferase subunit alpha | - |
| E0F34_RS02325 | briC | 422727..422912 (+) | 186 | WP_000148137.1 | biofilm-regulating peptide BriC | - |
| E0F34_RS11735 | - | 422930..423381 (+) | 452 | Protein_443 | hypothetical protein | - |
| E0F34_RS02335 | - | 423436..423630 (+) | 195 | WP_225791122.1 | CPBP family intramembrane glutamic endopeptidase | - |
Sequence
Protein
Download Length: 229 a.a. Molecular weight: 26880.19 Da Isoelectric Point: 6.9836
>NTDB_id=1126538 E0F34_RS02085 WP_000518011.1 377502..378191(+) (covR) [Streptococcus pneumoniae strain GPSC55 substr. ST3774 isolate b04a6400-1f66-11e7-b93e-3c4a9275d6c8]
MGKRILLLEKERNLAHFLSLELQKEQYRVDLVEEGQKALSMALQTDYDLILLNVNLGDMMAQDFAEKLSRTKPASVIMIL
DHWEDLQEELEVVQRFAVSYIYKPVLIENLVARISAIFRGRDFIDQHCSLMKVPRTYRNLRIDVEHHTVYRGEEMIALTR
REYDLLATLMGSKKVLTREQLLESVWKYESATETNIVDVYIRYLRSKLDVKGQKSYIKTVRGVGYTMQE
MGKRILLLEKERNLAHFLSLELQKEQYRVDLVEEGQKALSMALQTDYDLILLNVNLGDMMAQDFAEKLSRTKPASVIMIL
DHWEDLQEELEVVQRFAVSYIYKPVLIENLVARISAIFRGRDFIDQHCSLMKVPRTYRNLRIDVEHHTVYRGEEMIALTR
REYDLLATLMGSKKVLTREQLLESVWKYESATETNIVDVYIRYLRSKLDVKGQKSYIKTVRGVGYTMQE
Nucleotide
Download Length: 690 bp
>NTDB_id=1126538 E0F34_RS02085 WP_000518011.1 377502..378191(+) (covR) [Streptococcus pneumoniae strain GPSC55 substr. ST3774 isolate b04a6400-1f66-11e7-b93e-3c4a9275d6c8]
ATGGGGAAACGGATTTTATTACTTGAGAAAGAACGAAATCTAGCTCATTTTTTAAGTTTGGAACTCCAGAAAGAGCAGTA
TCGGGTTGATCTGGTAGAGGAGGGGCAAAAAGCCCTCTCCATGGCTCTTCAGACAGACTATGATTTGATTTTATTGAACG
TTAATCTGGGAGATATGATGGCTCAGGATTTTGCAGAAAAATTGAGCCGAACTAAACCTGCCTCAGTCATCATGATTTTA
GATCATTGGGAAGACTTGCAAGAAGAGCTGGAAGTTGTTCAGCGTTTTGCAGTTTCATACATCTATAAGCCAGTCCTTAT
CGAAAATCTGGTAGCGCGTATTTCGGCGATCTTCCGAGGTCGGGACTTCATTGATCAACACTGCAGTCTGATGAAAGTTC
CAAGGACCTACCGCAATCTTAGGATAGATGTTGAACATCACACGGTTTATCGTGGTGAAGAGATGATTGCTCTGACCCGC
CGTGAGTATGACCTTTTGGCGACACTTATGGGAAGCAAGAAAGTATTGACTCGTGAGCAATTGTTGGAAAGTGTTTGGAA
GTATGAAAGTGCGACCGAGACAAATATCGTAGATGTCTATATCCGCTATCTACGGAGCAAGCTTGATGTTAAAGGACAAA
AAAGCTACATTAAAACTGTGCGTGGTGTTGGATATACCATGCAAGAATAG
ATGGGGAAACGGATTTTATTACTTGAGAAAGAACGAAATCTAGCTCATTTTTTAAGTTTGGAACTCCAGAAAGAGCAGTA
TCGGGTTGATCTGGTAGAGGAGGGGCAAAAAGCCCTCTCCATGGCTCTTCAGACAGACTATGATTTGATTTTATTGAACG
TTAATCTGGGAGATATGATGGCTCAGGATTTTGCAGAAAAATTGAGCCGAACTAAACCTGCCTCAGTCATCATGATTTTA
GATCATTGGGAAGACTTGCAAGAAGAGCTGGAAGTTGTTCAGCGTTTTGCAGTTTCATACATCTATAAGCCAGTCCTTAT
CGAAAATCTGGTAGCGCGTATTTCGGCGATCTTCCGAGGTCGGGACTTCATTGATCAACACTGCAGTCTGATGAAAGTTC
CAAGGACCTACCGCAATCTTAGGATAGATGTTGAACATCACACGGTTTATCGTGGTGAAGAGATGATTGCTCTGACCCGC
CGTGAGTATGACCTTTTGGCGACACTTATGGGAAGCAAGAAAGTATTGACTCGTGAGCAATTGTTGGAAAGTGTTTGGAA
GTATGAAAGTGCGACCGAGACAAATATCGTAGATGTCTATATCCGCTATCTACGGAGCAAGCTTGATGTTAAAGGACAAA
AAAGCTACATTAAAACTGTGCGTGGTGTTGGATATACCATGCAAGAATAG
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| covR | Streptococcus salivarius strain HSISS4 |
48.261 |
100 |
0.485 |
| covR | Lactococcus lactis subsp. lactis strain DGCC12653 |
46.522 |
100 |
0.467 |