Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   E0F40_RS01770 Genome accession   NZ_LR216065
Coordinates   321378..322067 (+) Length   229 a.a.
NCBI ID   WP_000518007.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6     
Function   repress comR expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 315227..343439 321378..322067 within 0
IS/Tn 322135..323391 321378..322067 flank 68


Gene organization within MGE regions


Location: 315227..343439
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  E0F40_RS01735 (SAMEA3714487_00318) recU 315227..315823 (-) 597 WP_000248777.1 Holliday junction resolvase RecU -
  E0F40_RS01740 (SAMEA3714487_00319) - 315890..316417 (+) 528 WP_000179543.1 DUF1273 domain-containing protein -
  E0F40_RS01745 (SAMEA3714487_00320) gpsB 316487..316816 (+) 330 WP_000200643.1 cell division regulator GpsB -
  E0F40_RS01755 (SAMEA3714487_00321) - 317302..318459 (+) 1158 WP_000711402.1 THUMP domain-containing class I SAM-dependent RNA methyltransferase -
  E0F40_RS01760 (SAMEA3714487_00322) mapZ 318472..319866 (+) 1395 WP_000039286.1 cell division site-positioning protein MapZ -
  E0F40_RS01765 (SAMEA3714487_00323) gndA 319942..321366 (+) 1425 WP_000158797.1 NADP-dependent phosphogluconate dehydrogenase -
  E0F40_RS01770 (SAMEA3714487_00324) covR 321378..322067 (+) 690 WP_000518007.1 response regulator transcription factor Regulator
  E0F40_RS01775 (SAMEA3714487_00325) - 322135..323391 (-) 1257 WP_000436409.1 ISL3 family transposase -
  E0F40_RS01785 (SAMEA3714487_00326) cbpC 323587..324552 (+) 966 WP_000771105.1 choline-binding protein CbpC -
  E0F40_RS01790 (SAMEA3714487_00327) cbpJ 324571..325569 (+) 999 WP_000771134.1 choline-binding protein CbpJ -
  E0F40_RS01795 (SAMEA3714487_00328) - 325687..326919 (-) 1233 WP_000765664.1 MFS transporter -
  E0F40_RS01800 (SAMEA3714487_00329) - 326930..327550 (-) 621 WP_000153867.1 lanthionine synthetase LanC family protein -
  E0F40_RS01805 - 327450..327788 (-) 339 WP_001834993.1 lanthionine synthetase LanC family protein -
  E0F40_RS11975 - 328450..328617 (+) 168 Protein_341 transposase -
  E0F40_RS01825 (SAMEA3714487_00331) mvk 328903..329781 (+) 879 WP_000163323.1 mevalonate kinase -
  E0F40_RS01830 (SAMEA3714487_00332) mvaD 329763..330716 (+) 954 WP_000373457.1 diphosphomevalonate decarboxylase -
  E0F40_RS01835 (SAMEA3714487_00333) - 330703..331710 (+) 1008 WP_000562412.1 phosphomevalonate kinase -
  E0F40_RS01840 (SAMEA3714487_00334) fni 331694..332704 (+) 1011 WP_000210617.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  E0F40_RS01845 (SAMEA3714487_00335) liaF 332781..333479 (+) 699 WP_001224637.1 cell wall-active antibiotics response protein LiaF -
  E0F40_RS01850 (SAMEA3714487_00336) - 333476..334471 (+) 996 WP_000743666.1 sensor histidine kinase -
  E0F40_RS01855 (SAMEA3714487_00337) - 334485..335117 (+) 633 WP_000698434.1 response regulator transcription factor -
  E0F40_RS11980 - 335193..335887 (+) 695 Protein_349 DNA alkylation repair protein -
  E0F40_RS01875 (SAMEA3714487_00339) - 336037..336276 (+) 240 WP_000754502.1 hypothetical protein -
  E0F40_RS01880 (SAMEA3714487_00340) cbpG 336357..337178 (+) 822 WP_001100136.1 choline-binding protein CbpG -
  E0F40_RS01885 cbpF 337197..338219 (+) 1023 Protein_352 choline-binding protein CbpF -
  E0F40_RS11700 - 338347..339482 (-) 1136 Protein_353 IS3 family transposase -
  E0F40_RS01895 (SAMEA3714487_00347) - 339691..341460 (+) 1770 WP_000391671.1 PTS mannitol-specific transporter subunit IIBC -
  E0F40_RS01900 (SAMEA3714487_00348) - 341484..343439 (+) 1956 WP_000927661.1 BglG family transcription antiterminator -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26896.17 Da        Isoelectric Point: 6.9836

>NTDB_id=1126323 E0F40_RS01770 WP_000518007.1 321378..322067(+) (covR) [Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6]
MGKRILLLEKERNLAHFLSLELQKEQYRVDLVEEGQKALSMALQTDYDLILLNVNLGDMMAQDFAEKLSRTKPASVIMIL
DHWEDLQEELEVVQRFAVSYIYKPVFIENLVARISAIFRGRDFIDQHCSLMKVPRTYRNLRIDVEHHTVYRGEEMIALTR
REYDLLATLMGSKKVLTREQLLESVWKYESATETNIVDVYIRYLRSKLDVKGQKSYIKTVRGVGYTIQE

Nucleotide


Download         Length: 690 bp        

>NTDB_id=1126323 E0F40_RS01770 WP_000518007.1 321378..322067(+) (covR) [Streptococcus pneumoniae strain GPSC18 substr. ST13 isolate 55896440-41bd-11e5-998e-3c4a9275d6c6]
ATGGGGAAACGGATTTTATTACTTGAGAAAGAACGAAATCTAGCTCATTTTTTAAGTTTGGAACTCCAGAAAGAGCAGTA
TCGGGTTGATCTGGTAGAGGAGGGGCAAAAAGCCCTTTCCATGGCTCTTCAGACAGACTATGATTTGATTTTATTGAACG
TTAATCTGGGAGATATGATGGCTCAGGATTTTGCAGAAAAATTGAGTCGAACTAAACCTGCCTCAGTCATCATGATTTTA
GATCATTGGGAAGATTTGCAAGAAGAGCTGGAAGTTGTTCAGCGTTTTGCAGTTTCATACATCTATAAGCCAGTCTTTAT
CGAAAATCTGGTAGCGCGTATTTCGGCGATCTTCCGAGGTCGGGACTTCATTGATCAACACTGTAGTCTGATGAAAGTTC
CAAGGACCTACCGCAATCTTAGGATAGATGTTGAACATCACACGGTTTATCGTGGTGAAGAGATGATTGCTCTGACCCGC
CGTGAGTATGACCTTTTGGCGACACTTATGGGAAGCAAGAAAGTATTGACTCGTGAGCAATTGTTGGAAAGTGTTTGGAA
GTATGAAAGTGCGACCGAGACAAATATCGTAGATGTCTATATCCGCTATCTACGGAGCAAGCTTGATGTTAAAGGCCAAA
AAAGCTACATTAAAACCGTGCGTGGTGTTGGATATACCATTCAAGAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-226)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

48.696

100

0.489
  covR Lactococcus lactis subsp. lactis strain DGCC12653

46.087

100

0.463

Multiple sequence alignment