Detailed information    

insolico Bioinformatically predicted

Overview

Name   comM   Type   Regulator
Locus tag   E0F31_RS09500 Genome accession   NZ_LR216064
Coordinates   1765347..1765967 (-) Length   206 a.a.
NCBI ID   WP_000839908.1    Uniprot ID   A0A0B7M636
Organism   Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6     
Function   fratricide immunity (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1756058..1777036 1765347..1765967 within 0


Gene organization within MGE regions


Location: 1756058..1777036
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  E0F31_RS09440 (SAMEA3714520_01777) - 1756058..1756390 (-) 333 WP_224781448.1 hypothetical protein -
  E0F31_RS09445 (SAMEA3714520_01778) - 1756614..1757003 (-) 390 Protein_1790 ImmA/IrrE family metallo-endopeptidase -
  E0F31_RS09450 (SAMEA3714520_01779) - 1757016..1757222 (-) 207 WP_000366086.1 hypothetical protein -
  E0F31_RS09455 (SAMEA3714520_01780) - 1757209..1757370 (-) 162 WP_001055999.1 helix-turn-helix domain-containing protein -
  E0F31_RS09460 (SAMEA3714520_01781) lytA 1757716..1758672 (-) 957 WP_000405234.1 N-acetylmuramoyl-L-alanine amidase LytA -
  E0F31_RS09465 (SAMEA3714520_01782) - 1759048..1760418 (-) 1371 WP_050206507.1 MATE family efflux transporter -
  E0F31_RS09475 (SAMEA3714520_01783) recA 1760724..1761890 (-) 1167 WP_001085463.1 recombinase RecA Machinery gene
  E0F31_RS09480 (SAMEA3714520_01784) cinA 1761945..1763201 (-) 1257 WP_000642707.1 competence/damage-inducible protein A Machinery gene
  E0F31_RS09485 (SAMEA3714520_01785) brpA 1763286..1764302 (-) 1017 WP_000239282.1 biofilm formation/cell division transcriptional regulator BrpA -
  E0F31_RS09490 (SAMEA3714520_01786) - 1764310..1764828 (-) 519 WP_000455537.1 GNAT family N-acetyltransferase -
  E0F31_RS09495 (SAMEA3714520_01787) tsaE 1764818..1765261 (-) 444 WP_000275589.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
  E0F31_RS09500 (SAMEA3714520_01788) comM 1765347..1765967 (-) 621 WP_000839908.1 hypothetical protein Regulator
  E0F31_RS09510 (SAMEA3714520_01789) - 1766350..1767213 (-) 864 WP_001861709.1 helix-turn-helix domain-containing protein -
  E0F31_RS12130 (SAMEA3714520_01790) - 1767406..1767576 (+) 171 WP_001227862.1 PhrA family quorum-sensing system peptide -
  E0F31_RS09520 (SAMEA3714520_01791) pneA1 1767679..1767903 (+) 225 WP_000181087.1 two-peptide bacteriocin subunit PneA1 -
  E0F31_RS09525 (SAMEA3714520_01792) pneA2 1767910..1768098 (+) 189 WP_000786759.1 two-peptide bacteriocin subunit PneA2 -
  E0F31_RS09530 (SAMEA3714520_01793) - 1768214..1771204 (+) 2991 WP_000875571.1 type 2 lanthipeptide synthetase LanM family protein -
  E0F31_RS09535 (SAMEA3714520_01794) - 1771554..1772258 (+) 705 WP_054363282.1 flavodoxin family protein -
  E0F31_RS09540 (SAMEA3714520_01795) - 1772239..1773168 (+) 930 WP_000912954.1 M50 family metallopeptidase -
  E0F31_RS09545 (SAMEA3714520_01796) - 1773165..1775273 (+) 2109 WP_000701298.1 peptidase domain-containing ABC transporter -
  E0F31_RS09550 (SAMEA3714520_01797) - 1775297..1777036 (+) 1740 WP_000699969.1 S8 family peptidase -

Sequence

Protein


Download         Length: 206 a.a.        Molecular weight: 23552.72 Da        Isoelectric Point: 10.1254

>NTDB_id=1126289 E0F31_RS09500 WP_000839908.1 1765347..1765967(-) (comM) [Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6]
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYIGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF

Nucleotide


Download         Length: 621 bp        

>NTDB_id=1126289 E0F31_RS09500 WP_000839908.1 1765347..1765967(-) (comM) [Streptococcus pneumoniae strain GPSC13 substr. ST473 isolate 569492b0-41bd-11e5-998e-3c4a9275d6c6]
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCTTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTAGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATATTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7M636

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comM Streptococcus pneumoniae D39

100

100

1
  comM Streptococcus pneumoniae R6

100

100

1
  comM Streptococcus pneumoniae TIGR4

100

100

1
  comM Streptococcus mitis NCTC 12261

38.974

94.66

0.369
  comM Streptococcus mitis SK321

38.974

94.66

0.369

Multiple sequence alignment