Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   EL087_RS06700 Genome accession   NZ_LR134288
Coordinates   1369841..1370530 (-) Length   229 a.a.
NCBI ID   WP_126407624.1    Uniprot ID   A0A4U9ZMC9
Organism   Streptococcus milleri strain NCTC11169     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1364841..1375530
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL087_RS06680 (NCTC11169_01385) nrdR 1365311..1365784 (-) 474 WP_003029936.1 transcriptional regulator NrdR -
  EL087_RS06685 (NCTC11169_01386) - 1365951..1366562 (+) 612 WP_126408161.1 hypothetical protein -
  EL087_RS06690 (NCTC11169_01387) - 1366609..1367424 (-) 816 WP_126407620.1 endonuclease/exonuclease/phosphatase family protein -
  EL087_RS06695 (NCTC11169_01388) - 1367441..1369630 (-) 2190 WP_126407622.1 PTS transporter subunit IIBC -
  EL087_RS06700 (NCTC11169_01389) covR 1369841..1370530 (-) 690 WP_126407624.1 response regulator transcription factor Regulator
  EL087_RS06705 (NCTC11169_01390) gndA 1370539..1371963 (-) 1425 WP_003030963.1 NADP-dependent phosphogluconate dehydrogenase -
  EL087_RS06710 (NCTC11169_01391) - 1372262..1372885 (-) 624 WP_126407626.1 DNA alkylation repair protein -
  EL087_RS06715 (NCTC11169_01392) - 1372936..1373472 (-) 537 WP_021001984.1 DUF177 domain-containing protein -
  EL087_RS06720 (NCTC11169_01393) - 1373585..1374442 (+) 858 WP_126407628.1 Rgg/GadR/MutR family transcriptional regulator -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26472.55 Da        Isoelectric Point: 6.2732

>NTDB_id=1120269 EL087_RS06700 WP_126407624.1 1369841..1370530(-) (covR) [Streptococcus milleri strain NCTC11169]
MAKRILLVEKEKKLAQFIGLELQKEGYRVDLFETGKDALASVRANQYDLFLLNFMLDDMTGTEFAAQLSVIKPASVIIVL
DNRDNILQYTEEIQRFAVAYMVEPFIVTDLVEKISAIFRGRDFIDQHCSQMKVPTSYRNLRIDVQNHTVYRGEEVIALTR
REYDLLATLMGSHQALSREQLLERVWKYEGAVETNVVDVYIRYLRSKIDIAGQKSYIKTVRGVGYAMQE

Nucleotide


Download         Length: 690 bp        

>NTDB_id=1120269 EL087_RS06700 WP_126407624.1 1369841..1370530(-) (covR) [Streptococcus milleri strain NCTC11169]
ATGGCGAAGCGGATTTTATTAGTTGAGAAAGAAAAAAAATTAGCGCAATTTATTGGCTTAGAATTACAAAAAGAAGGTTA
TCGGGTTGATCTTTTCGAAACGGGAAAAGATGCTTTGGCGTCTGTGCGAGCGAATCAATACGATTTATTCCTGTTGAATT
TTATGCTTGACGATATGACAGGAACAGAATTTGCCGCACAATTAAGTGTGATAAAGCCTGCTTCGGTCATCATTGTATTG
GATAATCGTGATAATATTCTTCAATATACTGAGGAAATCCAACGCTTTGCTGTTGCTTACATGGTAGAACCATTCATTGT
GACGGACTTAGTTGAAAAAATTTCTGCCATTTTTCGTGGGCGTGATTTTATTGACCAGCATTGTAGTCAGATGAAAGTTC
CAACATCTTATCGGAATCTTCGGATTGATGTGCAAAATCATACAGTTTATCGAGGTGAAGAAGTGATTGCTTTGACTCGA
AGAGAGTATGATTTATTAGCAACATTGATGGGAAGTCATCAGGCTTTAAGCCGTGAACAGTTGTTAGAACGCGTGTGGAA
ATACGAAGGAGCTGTTGAAACAAATGTTGTCGATGTTTATATTCGTTATCTTCGTAGTAAAATTGATATAGCGGGGCAAA
AAAGTTATATAAAAACCGTGCGTGGTGTTGGTTATGCTATGCAAGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-227)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4U9ZMC9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

47.826

100

0.48
  covR Lactococcus lactis subsp. lactis strain DGCC12653

44.978

100

0.45

Multiple sequence alignment