Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpX   Type   Regulator
Locus tag   EL087_RS03760 Genome accession   NZ_LR134288
Coordinates   759814..761046 (+) Length   410 a.a.
NCBI ID   WP_003027977.1    Uniprot ID   I0SHV1
Organism   Streptococcus milleri strain NCTC11169     
Function   require for competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 758066..768942 759814..761046 within 0


Gene organization within MGE regions


Location: 758066..768942
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL087_RS03745 (NCTC11169_00743) - 758066..758905 (+) 840 WP_126406919.1 thymidylate synthase -
  EL087_RS03750 (NCTC11169_00744) - 759090..759602 (+) 513 WP_126406921.1 dihydrofolate reductase -
  EL087_RS03755 (NCTC11169_00745) - 759603..759776 (+) 174 WP_003024903.1 hypothetical protein -
  EL087_RS03760 (NCTC11169_00746) clpX 759814..761046 (+) 1233 WP_003027977.1 ATP-dependent Clp protease ATP-binding subunit ClpX Regulator
  EL087_RS03765 (NCTC11169_00747) yihA 761058..761645 (+) 588 WP_126406923.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
  EL087_RS03770 (NCTC11169_00748) - 761768..762475 (+) 708 WP_049512925.1 glucosaminidase domain-containing protein -
  EL087_RS03775 (NCTC11169_00749) - 762648..764393 (+) 1746 WP_126406925.1 ABC transporter ATP-binding protein -
  EL087_RS03780 (NCTC11169_00750) - 764374..766122 (+) 1749 WP_126406927.1 ABC transporter ATP-binding protein -
  EL087_RS03785 (NCTC11169_00751) - 766143..767678 (-) 1536 WP_126406929.1 ATP-binding cassette domain-containing protein -
  EL087_RS03790 (NCTC11169_00752) - 768202..768942 (-) 741 WP_126406931.1 amino acid ABC transporter ATP-binding protein -

Sequence

Protein


Download         Length: 410 a.a.        Molecular weight: 45688.21 Da        Isoelectric Point: 4.4242

>NTDB_id=1120261 EL087_RS03760 WP_003027977.1 759814..761046(+) (clpX) [Streptococcus milleri strain NCTC11169]
MPTNRTNEMMVYCSFCGKSQEEVQKIIAGNNAFICNECVELAQEIIREELAEEVLADLSEVPKPQELLNILNHYVIGQDR
AKRALAVAVYNHYKRINFHDNREDEEDVELQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATALTEAGYVGEDVEN
ILLKLLQAADFNIERAERGIIYVDEIDKIAKKSENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPQQEMIQVDT
KNILFIVGGAFDGIEEIVKQRLGEKIIGFGQNNKAIDETGSYMQEIISEDIQKFGLIPELIGRLPVFAALEPLTVDDLVR
ILREPKNALVKQYQTLLSYDDVKLEFDDDALQEIANKAIERKTGARGLRSIIEETMMDVMFEVPSQENVKLVRITKEAVD
GTDKPILETA

Nucleotide


Download         Length: 1233 bp        

>NTDB_id=1120261 EL087_RS03760 WP_003027977.1 759814..761046(+) (clpX) [Streptococcus milleri strain NCTC11169]
ATGCCTACAAATCGTACAAACGAAATGATGGTTTATTGTTCTTTTTGTGGTAAAAGCCAAGAAGAAGTGCAAAAGATCAT
CGCAGGAAATAATGCCTTTATTTGTAATGAATGTGTGGAATTAGCACAAGAAATCATCAGAGAGGAACTAGCAGAAGAAG
TGCTAGCAGACTTGTCAGAAGTGCCAAAACCACAAGAATTACTCAATATTTTGAATCACTATGTGATTGGACAAGACCGT
GCTAAGCGTGCTTTGGCTGTGGCTGTCTACAATCACTATAAACGCATCAATTTTCATGATAATCGTGAAGATGAGGAAGA
TGTCGAATTGCAGAAATCCAATATCCTTATGATTGGTCCAACTGGTTCTGGCAAGACCTTCCTCGCTCAAACCTTAGCAA
AAAGTCTGAATGTTCCTTTTGCGATTGCAGATGCGACAGCTTTGACAGAAGCTGGGTATGTCGGAGAAGATGTTGAAAAT
ATTCTCTTGAAACTCTTGCAAGCAGCAGATTTCAATATTGAGCGTGCTGAACGTGGTATCATCTATGTAGATGAGATTGA
CAAAATTGCGAAGAAAAGCGAAAATGTCTCTATTACTCGTGATGTGTCTGGTGAAGGTGTTCAGCAAGCGCTCCTCAAGA
TTATTGAAGGAACTGTAGCCAGCGTACCTCCGCAAGGCGGCCGCAAGCATCCTCAACAAGAGATGATTCAAGTAGATACG
AAAAATATTCTCTTTATCGTTGGTGGTGCATTTGACGGTATTGAAGAAATTGTCAAACAACGTCTAGGCGAAAAAATTAT
CGGTTTTGGTCAAAACAATAAGGCCATTGATGAAACTGGTTCTTATATGCAAGAAATCATCTCTGAAGATATTCAAAAAT
TTGGCTTGATTCCTGAATTGATTGGTCGTTTGCCTGTGTTTGCAGCGCTTGAGCCTTTAACAGTTGATGATTTGGTGCGA
ATCCTTCGCGAACCAAAGAATGCTTTAGTGAAGCAATATCAGACTCTTCTTTCTTATGATGATGTCAAATTGGAGTTTGA
TGATGATGCTCTTCAGGAAATCGCTAACAAGGCCATTGAACGCAAGACAGGTGCGCGTGGATTACGTTCGATTATCGAGG
AAACTATGATGGATGTCATGTTTGAAGTTCCAAGTCAAGAAAATGTGAAGCTGGTACGGATTACTAAGGAAGCAGTTGAC
GGAACGGATAAGCCGATTTTAGAAACAGCATAA

Domains

Predicted by InterproScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(313-390)

ClpX C4-type zinc finger (zf-C4_ClpX)

(12-48)

AAA domain (Cdc48 subfamily) (AAA_2)

(111-306)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB I0SHV1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpX Streptococcus mutans UA159

86.829

100

0.868
  clpX Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

58.458

98.049

0.573

Multiple sequence alignment