Detailed information NTG1120113

Bioinformatically predicted

Overview

• Name: clpX
• Type: Regulator
• Locus tag: EL070_RS06080
• Genome accession: NZ_LR134284
• Coordinates: 1152398..1153627 (-)
• Length: 409 a.a.
• NCBI ID: WP_011888976.1
• Uniprot ID: A2RF17
• Organism: Streptococcus pyogenes strain NCTC8232
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1147398..1158627

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL070_RS06065 (NCTC8232_01221)	-	1148741..1150840 (+)	2100	WP_111705569.1	AAA family ATPase	-
EL070_RS06070 (NCTC8232_01222)	-	1150898..1151641 (-)	744	WP_002984942.1	hypothetical protein	-
EL070_RS06075 (NCTC8232_01223)	yihA	1151789..1152388 (-)	600	WP_011184414.1	ribosome biogenesis GTP-binding protein YihA/YsxC	-
EL070_RS06080 (NCTC8232_01224)	clpX	1152398..1153627 (-)	1230	WP_011888976.1	ATP-dependent Clp protease ATP-binding subunit ClpX	Regulator
EL070_RS06090 (NCTC8232_01226)	-	1153947..1154444 (-)	498	WP_002984955.1	dihydrofolate reductase	-
EL070_RS06095 (NCTC8232_01227)	-	1154524..1155363 (-)	840	WP_011017679.1	thymidylate synthase	-
EL070_RS06100 (NCTC8232_01228)	-	1155572..1156747 (+)	1176	WP_021299369.1	hydroxymethylglutaryl-CoA synthase	-
EL070_RS06105 (NCTC8232_01229)	-	1156734..1158011 (+)	1278	WP_011017677.1	hydroxymethylglutaryl-CoA reductase, degradative	-

Sequence

Protein

• Length: 409 a.a.
• Molecular weight: 45006.50 Da
• Isoelectric Point: 4.6184

>NTDB_id=1120113 EL070_RS06080 WP_011888976.1 1152398..1153627(-) (clpX) [Streptococcus pyogenes strain NCTC8232]
MAGSRTNDIKVYCSFCGKSQDDVKKIIAGNNVFICNECVALSQEIIKEELAEEVLADLTEVPKPKELLDVLNQYVVGQDR
AKRALSVAVYNHYKRVSFTESRDDDDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENI
LLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTK
NILFIVGGAFDGIEEIVKQRLGEKVIGFGQNSRKIDDNASYMQEIISEDIQKFGLIPEFIGRLPVVAALEQLNTSDLIRI
LTEPRNALVKQYQALLSYDGVELEFDKAALEAIATKAIERKTGARGLRSIIEETMLDIMFEIPSQEDVTKVRITKAAVEG
KSKPVLETA

Nucleotide

• Length: 1230 bp

>NTDB_id=1120113 EL070_RS06080 WP_011888976.1 1152398..1153627(-) (clpX) [Streptococcus pyogenes strain NCTC8232]
ATGGCAGGAAGTAGAACTAACGATATTAAAGTATACTGTTCATTTTGTGGTAAAAGCCAGGATGACGTTAAAAAAATTAT
CGCAGGAAATAATGTTTTCATTTGCAATGAATGCGTAGCTTTATCACAAGAAATTATAAAAGAAGAATTGGCTGAAGAAG
TCCTTGCCGATTTGACAGAAGTTCCAAAACCAAAAGAGCTCCTTGATGTTTTAAATCAATATGTGGTTGGTCAAGATCGT
GCTAAACGTGCTTTATCAGTTGCTGTGTACAATCATTATAAGCGTGTCTCGTTTACAGAAAGTCGTGATGACGATGATGT
GGATTTACAAAAGTCCAACATTTTGATGATTGGACCAACAGGTTCAGGAAAAACCTTCTTAGCACAAACTCTGGCTAAAA
GCCTCAATGTACCATTTGCTATTGCAGATGCAACTTCTTTGACTGAAGCAGGGTATGTTGGAGAAGATGTGGAAAATATT
TTACTCAAACTGATTCAGGCTGCTGACTATAATGTCGAACGAGCAGAGCGTGGTATTATTTATGTTGATGAAATAGATAA
GATTGCTAAAAAAGGTGAGAACGTATCTATCACACGTGATGTATCTGGTGAAGGTGTACAGCAAGCCCTTCTTAAAATTA
TTGAAGGTACGGTAGCAAGTGTTCCCCCACAAGGTGGGCGGAAGCACCCTAATCAAGAAATGATCCAAATTGATACAAAA
AATATCTTGTTTATTGTTGGCGGGGCTTTTGATGGCATCGAGGAGATTGTTAAACAACGTTTAGGTGAAAAAGTTATTGG
TTTTGGTCAAAACAGCCGTAAAATTGATGACAATGCTTCTTATATGCAAGAAATTATTTCAGAAGATATTCAAAAGTTTG
GGCTTATTCCAGAATTTATTGGCCGCTTACCAGTTGTGGCAGCCCTTGAACAACTAAACACATCAGATTTGATTCGAATC
TTAACAGAGCCAAGGAATGCTCTTGTCAAGCAATATCAGGCCCTTCTTTCCTATGATGGGGTTGAATTAGAATTTGATAA
AGCAGCTCTTGAAGCTATCGCAACTAAAGCCATTGAACGTAAGACAGGAGCACGTGGTCTTCGTTCTATTATCGAAGAAA
CGATGCTTGACATCATGTTTGAAATTCCAAGCCAAGAAGATGTCACAAAAGTGCGTATCACCAAGGCTGCTGTCGAAGGC
AAGTCAAAACCCGTTTTAGAGACAGCTTAA

Domains

Predicted by InterproScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (110-305)

• ClpX C4-type zinc finger (zf-C4_ClpX) (12-48)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (312-391)

3D structure

• AlphaFold DB: A2RF17

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpX	Streptococcus mutans UA159	88.998	100	0.89
clpX	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	58.853	98.044	0.577