Detailed information NTG1119434

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: EL101_RS04505
• Genome accession: NZ_LR134263
• Coordinates: 996511..997554 (+)
• Length: 347 a.a.
• NCBI ID: WP_019166463.1
• Uniprot ID: A0A2A4GVQ0
• Organism: Staphylococcus delphini strain NCTC12225
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 991511..1002554

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL101_RS04485 (NCTC12225_00929)	-	993457..994455 (-)	999	WP_096542445.1	aromatic acid exporter family protein	-
EL101_RS04490 (NCTC12225_00930)	map	994552..995313 (+)	762	WP_019166460.1	type I methionyl aminopeptidase	-
EL101_RS04495 (NCTC12225_00931)	-	995411..995800 (+)	390	WP_096597673.1	hypothetical protein	-
EL101_RS04500 (NCTC12225_00932)	liaF	995813..996514 (+)	702	WP_096597675.1	cell wall-active antibiotics response protein LiaF	-
EL101_RS04505 (NCTC12225_00933)	vraS	996511..997554 (+)	1044	WP_019166463.1	sensor histidine kinase	Regulator
EL101_RS04510 (NCTC12225_00934)	vraR	997544..998173 (+)	630	WP_014613482.1	response regulator transcription factor	Regulator
EL101_RS04515 (NCTC12225_00935)	-	999056..999637 (-)	582	WP_096597677.1	carbonic anhydrase	-
EL101_RS04520 (NCTC12225_00936)	-	999670..1001007 (-)	1338	WP_096597679.1	YihY/virulence factor BrkB family protein	-
EL101_RS04525 (NCTC12225_00937)	-	1001223..1001510 (-)	288	WP_014613485.1	YtxH domain-containing protein	-
EL101_RS04530 (NCTC12225_00938)	-	1001518..1001976 (-)	459	WP_019166466.1	low molecular weight protein-tyrosine-phosphatase	-
EL101_RS04535 (NCTC12225_00939)	-	1002110..1002313 (+)	204	WP_019169369.1	DUF1128 family protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39911.18 Da
• Isoelectric Point: 5.0397

>NTDB_id=1119434 EL101_RS04505 WP_019166463.1 996511..997554(+) (vraS) [Staphylococcus delphini strain NCTC12225]
MNHYVRAIGSMLILVYSMLTAFFFIDKVFTNIIFFQGMFYTQILGIPVFIFLNLVVIFLCIIVGSVLAYKINQQNDWVKQ
QIVRAFEGETVGINDQQLELYNETIELYQALVPLNQELHKMRIKTQNLTNETYNLNDLKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETDLAPPLDQQIPTLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKSLVTDLQRKVPIKVVQEI
DEFEVPKGIEDHLFRITQEAISNTLRHAEGTQVTVELLNRNDYLLLRIQDDGIGFNVDDKLEQSYGLKNMRERAIEIGAT
FHIVSLPDAGTRIEVKAPLEKEEQHDN

Nucleotide

• Length: 1044 bp

>NTDB_id=1119434 EL101_RS04505 WP_019166463.1 996511..997554(+) (vraS) [Staphylococcus delphini strain NCTC12225]
ATGAATCACTACGTCCGAGCGATAGGTTCGATGCTCATTCTCGTATATAGTATGCTCACCGCGTTTTTCTTTATCGATAA
AGTGTTTACCAATATTATTTTCTTTCAAGGCATGTTTTATACACAAATTTTAGGGATTCCTGTTTTTATCTTTTTAAATT
TAGTCGTCATTTTTTTATGTATTATCGTGGGCAGTGTGTTAGCTTATAAAATCAATCAACAAAATGATTGGGTGAAGCAA
CAAATCGTTCGTGCTTTCGAAGGCGAAACAGTGGGAATCAATGATCAACAACTTGAGCTGTATAATGAAACGATTGAATT
GTACCAAGCGCTCGTCCCATTGAATCAAGAACTGCATAAAATGCGGATTAAAACACAAAATTTAACGAATGAAACGTATA
ATTTAAATGATTTGAAGGTGAAAAAGATTATAGAAGATGAACGGCAGCGTTTAGCACGAGAATTGCATGATAGTGTGTCG
CAACAACTTTTCGCGGCAAGTATGATGTTGTCTGCAATCAAGGAAACAGATTTAGCTCCACCGTTAGACCAACAAATTCC
AACGTTAGAAAAAATGGTGCAAGACTCACAACTTGAAATGCGTGCACTGTTACTTCATTTAAGACCTATAGGATTGAAGG
ATAAATCGTTAGGTGAGGGGATAAAATCGCTCGTGACGGATTTACAACGCAAAGTGCCCATTAAAGTCGTGCAAGAAATT
GATGAGTTTGAAGTCCCTAAAGGTATTGAGGATCACCTTTTTAGGATTACCCAAGAAGCGATTTCCAATACGTTACGACA
TGCTGAGGGAACGCAAGTAACAGTAGAATTACTTAACCGCAATGATTATTTATTGTTGCGTATACAAGATGACGGCATTG
GATTTAATGTCGATGATAAATTAGAACAAAGTTATGGATTAAAAAATATGCGTGAACGTGCAATAGAGATTGGTGCCACG
TTTCATATCGTCTCATTACCTGATGCAGGGACGAGAATAGAAGTGAAAGCACCACTTGAAAAGGAGGAACAGCATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-341)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A2A4GVQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	83.573	100	0.836