Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   ELZ47_RS08415 Genome accession   NZ_LR134002
Coordinates   1695702..1697972 (+) Length   756 a.a.
NCBI ID   WP_125330596.1    Uniprot ID   -
Organism   Streptococcus sanguinis strain NCTC 10904     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1690702..1702972
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ELZ47_RS08380 (NCTC10904_01642) - 1690754..1690966 (-) 213 WP_002896137.1 exodeoxyribonuclease VII small subunit -
  ELZ47_RS08385 (NCTC10904_01643) xseA 1690944..1692284 (-) 1341 WP_126435802.1 exodeoxyribonuclease VII large subunit -
  ELZ47_RS08395 (NCTC10904_01644) - 1692440..1693300 (-) 861 WP_125330593.1 NAD(P)H-hydrate dehydratase -
  ELZ47_RS08400 (NCTC10904_01645) - 1693408..1694181 (-) 774 WP_125330594.1 HAD hydrolase family protein -
  ELZ47_RS08405 (NCTC10904_01646) - 1694178..1695032 (-) 855 WP_125330595.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  ELZ47_RS08410 (NCTC10904_01647) - 1695222..1695452 (-) 231 WP_002896146.1 DUF1797 family protein -
  ELZ47_RS08415 (NCTC10904_01648) clpE 1695702..1697972 (+) 2271 WP_125330596.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  ELZ47_RS08420 (NCTC10904_01649) - 1698021..1698635 (-) 615 WP_125330597.1 GyrI-like domain-containing protein -
  ELZ47_RS08425 (NCTC10904_01650) - 1698695..1699594 (-) 900 WP_125330598.1 helix-turn-helix transcriptional regulator -
  ELZ47_RS08435 (NCTC10904_01651) - 1699819..1700268 (+) 450 WP_125330600.1 NUDIX hydrolase -
  ELZ47_RS08440 (NCTC10904_01652) - 1700336..1700638 (+) 303 WP_002919443.1 DUF1827 family protein -
  ELZ47_RS08445 (NCTC10904_01653) - 1700663..1701097 (-) 435 WP_125330601.1 GNAT family N-acetyltransferase -
  ELZ47_RS08450 (NCTC10904_01654) - 1701120..1701575 (+) 456 WP_125330602.1 MarR family winged helix-turn-helix transcriptional regulator -

Sequence

Protein


Download         Length: 756 a.a.        Molecular weight: 83707.75 Da        Isoelectric Point: 4.9408

>NTDB_id=1117828 ELZ47_RS08415 WP_125330596.1 1695702..1697972(+) (clpE) [Streptococcus sanguinis strain NCTC 10904]
MLCQNCKINESTIHLYTNVNGHKQQVDLCQNCYQIMKTDPEHSLFGGIANANNHGTDPIDDFFNSLSNFQQPQEPTTPPT
QSGGAYGGGGGYGSNPSKGGQPQPSPQKPKGMLEEFGINVTELARRGEIDPVIGRDEEIVRVIEILNRRTKNNPVLIGEP
GVGKTAVVEGLAQKIVDGDVPHKLQGKEVIRLDVVSLVQGTGIRGQFEERMQKLIDEIRSRQDVILFIDEIHEIVGAGSA
GDGNMDAGNILKPALARGELQMVGATTLNEYRIIEKDAALERRMQPVKVDEPTVEETITILKGIQKKYEDYHHVKYTDAA
IEAAALLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKAQATRDEDFEKAAYFRDQIAKYKEL
QQTSVLDKDTPIISEKTIEHIVEQKTNIPVGDLKEKEQSQLVNLSSDLKAHVIGQDDAVDKIAKAIRRNRVGLGSPNRPI
GSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTERVRRNPYSLILLDE
VEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKAEASVGFGAAREGRTNSVLGELGNFFSPEFMNRF
DGIIEFQALSKDDLLQIVNLMLDDVNQRLATNDIHLDVTEKVKEKLVDLGYDPKMGARPLRRTIQDHIEDAITDFYLENP
SEKELKAIMTSNGKILIKSAKKTESTESVNSSQEEK

Nucleotide


Download         Length: 2271 bp        

>NTDB_id=1117828 ELZ47_RS08415 WP_125330596.1 1695702..1697972(+) (clpE) [Streptococcus sanguinis strain NCTC 10904]
ATGCTTTGTCAAAATTGTAAAATCAATGAATCTACGATTCACCTTTATACCAATGTAAATGGCCATAAACAGCAGGTGGA
TTTGTGCCAAAACTGCTACCAAATCATGAAAACAGACCCTGAACATTCCTTGTTCGGCGGAATTGCTAATGCCAACAATC
ACGGAACAGATCCTATTGATGACTTCTTCAACAGCCTCAGCAATTTTCAACAGCCTCAGGAACCAACTACTCCTCCTACC
CAATCTGGCGGGGCCTATGGAGGCGGTGGCGGATACGGTTCCAATCCTAGCAAAGGTGGTCAGCCTCAGCCAAGTCCGCA
AAAGCCAAAAGGCATGCTGGAAGAGTTTGGTATCAATGTGACCGAGTTGGCTCGCCGAGGCGAGATTGATCCTGTTATTG
GTCGTGATGAAGAAATCGTCCGTGTCATTGAAATCCTCAACCGCCGCACCAAAAACAATCCTGTTCTCATAGGAGAGCCA
GGAGTCGGAAAAACAGCCGTGGTGGAAGGTCTGGCCCAGAAAATTGTCGATGGTGATGTGCCTCATAAACTCCAAGGCAA
AGAAGTTATCCGCCTAGACGTTGTCAGCTTAGTACAGGGAACTGGTATCCGTGGCCAATTTGAGGAGAGAATGCAGAAGC
TCATTGATGAGATTCGTTCTCGTCAAGATGTCATTCTCTTCATTGATGAAATCCATGAAATTGTTGGAGCAGGCTCTGCT
GGCGATGGCAATATGGACGCTGGGAACATCCTCAAACCAGCTCTGGCTCGCGGAGAACTCCAGATGGTCGGAGCAACCAC
CCTCAACGAATATCGTATCATCGAGAAGGATGCTGCACTTGAGCGTCGTATGCAGCCAGTTAAGGTGGACGAACCAACGG
TAGAGGAAACGATTACCATCCTCAAAGGAATTCAGAAAAAATACGAAGACTACCATCACGTCAAGTACACAGATGCGGCC
ATTGAAGCTGCTGCGCTTCTCTCCAACCGCTACATCCAAGACCGCTTCCTGCCAGACAAGGCTATTGACCTCTTGGATGA
GGCTGGTTCCAAGATGAATCTAACCCTCAACTTCGTTGATCCCAAGGTCATTGACCAACGTCTGATCGAAGCAGAAAACC
TCAAGGCTCAAGCAACCCGCGACGAAGACTTCGAGAAGGCGGCTTACTTCCGGGACCAGATTGCCAAGTACAAGGAACTC
CAGCAGACAAGTGTGCTAGACAAGGATACTCCGATTATCAGCGAGAAAACGATTGAGCACATCGTAGAGCAAAAGACCAA
TATTCCAGTCGGCGACCTCAAAGAAAAAGAACAGTCTCAACTAGTTAATCTCTCTAGTGACTTAAAGGCTCATGTCATCG
GTCAAGACGATGCTGTAGATAAGATTGCCAAGGCCATCCGCCGCAACCGAGTCGGACTAGGAAGTCCTAATCGCCCAATC
GGCAGCTTCCTCTTTGTCGGACCAACTGGTGTCGGTAAGACAGAGCTGTCTAAGCAATTAGCCATTGAGCTCTTTGGCTC
GGCTGACAGCATGATTCGCTTTGATATGAGTGAATATATGGAAAAACACAGCGTGGCCAAGCTGGTCGGTGCGCCTCCGG
GCTATGTCGGCTATGATGAAGCTGGTCAATTGACTGAGCGCGTTCGCCGCAATCCTTACTCACTCATTCTGCTGGATGAG
GTGGAAAAGGCCCATCCCGATGTTATGCACATGTTCCTGCAGGTTCTAGATGATGGCCGCCTGACCGATGGCCAAGGCCG
GACTGTCAGCTTCAAGGACACCATTATCATCATGACATCCAATGCCGGAACTGGCAAAGCTGAAGCCAGCGTTGGCTTTG
GAGCAGCGCGTGAAGGCCGCACTAACTCCGTTTTGGGTGAATTGGGGAACTTCTTCAGTCCTGAGTTTATGAACCGCTTT
GACGGCATTATCGAATTCCAGGCGCTCAGCAAGGACGATCTGCTGCAAATCGTCAACCTTATGCTGGACGATGTTAATCA
ACGTTTGGCAACCAACGACATTCATCTGGATGTTACAGAGAAGGTCAAAGAAAAATTGGTTGACCTGGGCTACGATCCAA
AAATGGGGGCTCGCCCACTACGCCGTACCATTCAGGACCATATCGAAGATGCTATTACTGACTTTTATCTGGAAAATCCA
AGCGAAAAAGAGCTCAAAGCTATCATGACCAGCAATGGCAAGATTCTCATCAAGTCAGCCAAGAAAACTGAAAGCACAGA
GTCCGTTAATTCATCACAAGAAGAAAAATAA

Domains

Predicted by InterproScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(649-723)

ATPase family associated with various cellular activities (AAA) (AAA)

(155-274)

AAA domain (Cdc48 subfamily) (AAA_2)

(478-641)

AAA lid domain (AAA_lid_9)

(293-390)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

85.997

100

0.861
  clpE Streptococcus pneumoniae D39

85.997

100

0.861
  clpE Streptococcus pneumoniae R6

85.997

100

0.861
  clpE Streptococcus pneumoniae TIGR4

85.865

100

0.86
  clpE Streptococcus mutans UA159

83.709

99.868

0.836
  clpC Lactococcus lactis subsp. cremoris KW2

76.627

99.603

0.763
  clpC Bacillus subtilis subsp. subtilis str. 168

48.821

95.37

0.466
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.846

85.979

0.411
  clpC Streptococcus pneumoniae Rx1

48.631

82.143

0.399
  clpC Streptococcus pneumoniae D39

48.631

82.143

0.399
  clpC Streptococcus pneumoniae TIGR4

48.47

82.143

0.398
  clpC Streptococcus thermophilus LMD-9

47.444

82.804

0.393
  clpC Streptococcus thermophilus LMG 18311

47.125

82.804

0.39
  clpC Streptococcus mutans UA159

47.125

82.804

0.39

Multiple sequence alignment